Results 141 to 150 of about 4,314 (176)

The chemistry of penicillanic acids. Part II. Some reactions of methyl penicillanate and its 6α-bromo- and 6,6-dibromo-derivatives

J. Chem. Soc., Perkin Trans. 1, 1974
The action of methyl iodide and strong anhydrous base on methyl penicillanate or its 6α-bromo-derivative leads to S-methylation and cleavage of both thiazolidine and β-lactam rings, but with methyl 6,6-dibromopenicillanate the β-lactam system remains intact.
J P, Clayton, J H, Nayler, M J, Pearson, R, Southgate   +3 more
openaire   +2 more sources

[A simple method of synthesis of S-sulfoxides of penicillanic acid and 6-alpha-bromo[chloro]-penicillanic acids].

Antibiotiki i khimioterapiia = Antibiotics and chemoterapy [sic], 1991
A simple method for synthesis of S-sulfoxides of penicillanic acid and 6 alpha-bromo- and 6 alpha-chloropenicillanic acids is described. The S-sulfoxides were synthesized by the respective oxidation with 30% hydrogen peroxide at 0 degrees C in the absence of solvents.
L S, Changov, B K, Vasileva-Lukanova, N N, Agapova, M M, Tsenkova, D M, Mondeshka, Z T, Ivanova   +5 more
openaire   +1 more source

ChemInform Abstract: Penicilloates Derived from Penicillanic Acid.

Chemischer Informationsdienst, 1982
AbstractDie Lactamspaltung der Penicillansäure (III) mit KOH liefert die isomeren Carboxymethylthiazolidincarbonsäuren (I) und (II), mit Alkalialkoholaten (IV) und (III) werden die Halbester (V) und (VI) erhalten, die mit α‐Diazotoluol (VII) zu den Benzylestern (VIII) und (IX) reagieren.
P. J. CLAES, P. HERDEWIJN, H. VADERHAEGHE   +2 more
openaire   +1 more source

Beta-Lactamase Inhibition by Acetylmethylene Penicillanic Acid Compared to that of Clavulanate and Sulbactam

Chemotherapy, 1988
The beta-lactamase inhibitory properties of 6-acetylmethylene penicillanic acid (6-AMPA) were investigated and compared with those of other beta-lactamase inhibitors. 6-AMPA inhibited the TEM-1, TEM-2, SHV-1, PSE-1, PSE-2, PSE-3, PSE-4, OXA-2, OXA-3, and Staphylococcus aureus beta-lactamases. It also inhibited the chromosomally-mediated beta-lactamases
N X, Chin, M J, McElrath, H C, Neu
openaire   +2 more sources

Synthesis of 3-carboxyisopenam sulphone: an analogue of penicillanic acid sulphone

Journal of the Chemical Society, Chemical Communications, 1980
The title compound has been prepared by a five-step sequence from 4-iodomethylazetidin-2-one.
Chandra M. Pant, Richard J. Stoodley
openaire   +1 more source

ChemInform Abstract: Γ‐LACTAM ANALOGS OF PENICILLANIC AND CARBAPENICILLANIC ACIDS

Chemischer Informationsdienst, 1985
AbstractAusgehend von der Reaktion zwischen dem Nitron (I) und dem Ester (II) werden auf dem beschriebenen Syntheseweg [Röntgenstrukturanalyse für (IIIb): RG ‐= PT; Z ‐ 2] die γ‐Lactame (V) und (VI) synthetisiert.
J. E. BALDWIN, M. F. CHAN, G. GALLACHER, M. OTSUKA, P. MONK, K. PROUT   +5 more
openaire   +1 more source

ChemInform Abstract: Γ‐LACTAM ANALOGS OF PENICILLANIC AND CARBAPENICILLANIC ACIDS

Chemischer Informationsdienst, 1983
AbstractNitroessigsäuremethylester (I) wird über (III) in das Pyrrolin‐N‐oxid (IV) umgewandelt, das über (V) und (VI) zu den Lactamanaloga (VII) führt.
J. E. BALDWIN, M. F. CHAN, G. GALLACHER, P. MONK, K. PROUT   +4 more
openaire   +1 more source

ELECTROCHEMICAL DEHOLOGENATION OF 6-HALOPENICILLANIC ACIDS INTERMEDIATES IN THE PREPARATION OF PENICILLANIC ACID SULPHONES

Rad Jugoslavenske akademije znanosti i umjetnosti. Razred za matematičke, fizičke i tehničke znanosti. Kemijske znanosti, 1986
Electrochemical dehalogenation of 6-halopenicillanic acids I gave penicillanic acids III. Dehalogenation of 6-halopenacillanic acid sulfones II obtained by the oxidation of I with H2O2/HOOH yielded penicillanic acid sulfones IV.
Lukić, Miroslav, Herak, Jure, Lukić, Irena, Gašpert, Branimir   +3 more
openaire   +1 more source

Penicillanic acids: requirements for epimerisation at C-6

Journal of the Chemical Society D: Chemical Communications, 1969
J. P. Clayton, J. H. C. Nayler, R. Southgate, E. R. Stove   +3 more
openaire   +1 more source

Antibacterial activity of 6-(5-membered heteroarylacetamido)penicillanic acids

Journal of Medicinal Chemistry, 1972
R G, Micetich, R, Raap, J, Howard, I, Pushkas   +3 more
openaire   +2 more sources