Synthesis of an Enzyme-Triggered Chitosan-Based Drug Delivery System for Peri-Implantitis Prevention. [PDF]
ChemistryABSTRACT Dental implants have become a leading solution for tooth loss, yet bacterial infections remain a major complication. Antibacterial implant coatings are an important approach to reduce or prevent bacterial infections at the implant. Given the oral cavity's complex microbiome and the importance of some commensal bacteria, it is crucial to ...
Nnane NS +7 more
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The crystal structure of human transport and Golgi organization 2 homolog (TANGO2) suggests a cysteine N-terminal nucleophile (Ntn) hydrolase. [PDF]
Acta Crystallogr D Struct BiolThis study reports the first crystal structure of human TANGO2, mutations of which are responsible for TANGO2 deficiency disorder. The crystallographic analysis demonstrates that interactions between heme and TANGO2 are nonspecific, helping to address ongoing questions about the role of TANGO2 as a heme‐trafficking protein.Recently, there has been ...
Zhou D, Chen L, Rose J, Wang BC.
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Palmitoylethanolamide (PEA) regulates cell cycle progression and promotes an anti-inflammatory transcriptomic signature in C2C12 skeletal muscle cells. [PDF]
Physiol RepAbstract Palmitoylethanolamide (PEA) is an endogenous lipid mediator with immunomodulatory actions, yet its effects in skeletal muscle remain poorly defined. We examined whether PEA influences myogenesis and profiled the acute transcriptomic response of differentiated C2C12 myotubes to 10 μM PEA. PEA decreased myotube number (90.3 ± 10.6 vs. 112.6 ± 10.
Cole PL +4 more
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Specificity of Penicillin Amidases
Experimental Biology and Medicine, 1963 SummaryA series of penicillins have been tested for splitting by amidases from several sources. The two distinct types as postulated by Rolinson et al.(5) were demonstrated. In addition, the amidases of bacterial origin showed a further specificity in that synthetic penicillins containing a carboxyl group on the side chain were not hydrolyzed ...
C A, CLARIDGE, J R, LUTTINGER, J, LEIN
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FtsZ-independent septal recruitment and function of cell wall remodelling enzymes in chlamydial pathogens. [PDF]
, 2014 The nature and assembly of the chlamydial division septum is poorly defined due to the paucity of a detectable peptidoglycan (PG)-based cell wall, the inhibition of constriction by penicillin and the presence of coding sequences for cell wall precursor ...
Frandi, A. +4 more
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Microbial Cell Factories, 2006 Background During the last years B. megaterium was continuously developed as production host for the secretion of proteins into the growth medium. Here, recombinant production and export of B. megaterium ATCC14945 penicillin G amidase (PGA) which is used
Jahn Dieter +6 more
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Self-immolative linkers in polymeric delivery systems [PDF]
, 2011 There has been significant interest in the methodologies of controlled release for a diverse range of applications spanning drug delivery, biological and chemical sensors, and diagnostics.
Blencowe, Christopher A +4 more
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Selection of amidases with novel substrate specificities from penicillin amidase of Escherichia coli [PDF]
Applied and Environmental Microbiology, 1989 To obtain amidases with novel substrate specificity, the cloned gene for penicillin amidase of Escherichia coli ATCC 11105 was mutagenized and mutants were selected for the ability to hydrolyze glutaryl-(L)-leucine and provide leucine to Leu- host cells. Cells with the wild-type enzyme did not grow in minimal medium containing glutaryl-(L)-leucine as a
L J, Forney, D C, Wong, D M, Ferber
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Engineering the substrate specificity of a thermophilic penicillin acylase from thermus thermophilus [PDF]
, 2013 A homologue of the Escherichia coli penicillin acylase is encoded in the genomes of several thermophiles, including in different Thermus thermophilus strains.
Berenguer, José +7 more
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Functional expression of a penicillin acylase from the extreme thermophile Thermus thermophilus HB27 in Escherichia coli [PDF]
, 2012 Background: Penicillin acylases (PACs) are enzymes of industrial relevance in the manufacture of beta-lactam antibiotics. Development of a PAC with a longer half-life under the reaction conditions used is essential for the improvement of the operational ...
Berenguer, José +4 more
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