Automated image segmentation and division plane detection in single live Staphylococcus aureus cells [PDF]
arXiv, 2016 Staphylococcus aureus is a coccal bacterium, which divides by binary fission. After division the cells remain attached giving rise to small clusters, with a characteristic 'bunch of grapes' morphology. S. aureus is an important human pathogen and this, combined with the increasing prevalence of antibiotic-resistant strains, such as Methicillin ...
arxiv
Transcriptome‐wide analysis of circRNA and RBP profiles and their molecular relevance for GBM
Molecular Oncology, EarlyView.CircRNAs are differentially expressed in glioblastoma primary tumors and might serve as therapeutic targets and diagnostic markers. The investigation of circRNA and RNA‐binding proteins (RBPs) interactions shows that distinct RBPs play a role in circRNA biogenesis and function.
Julia Latowska‐Łysiak +14 more
wiley +1 more source
PBP4: A New Perspective on Staphylococcus aureus β-Lactam Resistance. [PDF]
, 2018 β-lactam antibiotics are excellent drugs for treatment of staphylococcal infections, due to their superior efficacy and safety compared to other drugs.
Chambers, Henry F +3 more
core +3 more sources
Molecular Oncology, EarlyView.This study investigates an alternative approach to reactivating the oncosuppressor p53 in cancer. A short peptide targeting the association of the two p53 inhibitors, MDM2 and MDM4, induces an otherwise therapeutically active p53 with unique features that promote cell death and potentially reduce toxicity towards proliferating nontumor cells.
Sonia Valentini +10 more
wiley +1 more source
Using Hospital Antibiogram Data To Assess Regional Pneumococcal Resistance to Antibiotics
Emerging Infectious Diseases, 2003 Antimicrobial resistance to penicillin and macrolides in Streptococcus pneumoniae has increased in the United States over the past decade. Considerable geographic variation in susceptibility necessitates regional resistance tracking.
Cheryl R. Stein +2 more
doaj +1 more source
Previous antibiotic exposure and antibiotic resistance of commensal Staphylococcus aureus in Spanish primary care [PDF]
, 2018 Introduction: Commensal flora of healthy people is becoming an important reservoir of resistant bacteria. Objectives: To evaluate the relationship of previous antibiotic-dispensed and resistance pattern of strains of Staphylococcus aureus in primary care
Boada, Albert +5 more
core +1 more source
Electroforming Free Controlled Bipolar Resistive Switching in Al/CoFe2O4/FTO device with Self-Compliance Effect [PDF]
, 2018 Controlled bipolar resistive switching (BRS) has been observed in nanostructured CoFe2O4 films using Al(aluminum)/CoFe2O4/FTO(fluorine-doped tin oxide) device. The fabricated device shows electroforming-free uniform BRS with two clearly distinguished and stable resistance states without any application of compliance current (CC), with a resistance ...
arxiv +1 more source
Exploration of heterogeneity and recurrence signatures in hepatocellular carcinoma
Molecular Oncology, EarlyView.This study leveraged public datasets and integrative bioinformatic analysis to dissect malignant cell heterogeneity between relapsed and primary HCC, focusing on intercellular communication, differentiation status, metabolic activity, and transcriptomic profiles.
Wen‐Jing Wu +15 more
wiley +1 more source
Peptidoglycan synthesis and penicillin resistance in Streptococcus pneumoniae [PDF]
, 2018 "Resistance to penicillin in Streptococcus pneumoniae involves remodelling of penicillin-binding proteins (PBPs), enzymes involved in the last stages of peptidoglycan (PGN) synthesis, which reduce the affinity of these targets to the
Narciso, Ana Rita da Cruz
core
The antibiotic susceptibility pattern of gas gangrene-forming Clostridium spp. clinical isolates from South-Eastern Hungary [PDF]
, 2020 Introduction: Clostridium perfringens and other gas gangrene-forming clostridia are commensals of the human gut and vaginal microbiota, but can cause serious or even fatal infections.
Schoblocher Dzsenifer +1 more
core +1 more source