Results 101 to 110 of about 4,016,959 (341)

Capsular serotype and antibiotic resistance of group B streptococci isolated from pregnant women in Ardabil, Iran [PDF]

Background and Objectives: Group B Streptococci (GBS) is a major cause of neonatal and maternal infections. The aim of this study was to determine the serotype distribution and antibiotic resistance profile of GBS strains isolated from pregnant women in
ارزنلو, محسن, جنتی, الهام, حبیب زاده, شهرام, رحیمی, گیتی, روشنی, مرضیه, شاپوری, رضا   +5 more
core  

COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells

Molecular Oncology, EarlyView.
This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos, Gilar Gorji‐bahri, Lejla Gradjan, Julia Zajac, Kacper Gil, Yvonne Thokozile Nduku, Anna M. Blom   +6 more
wiley   +1 more source

A Newer In Vitro Model for the Study of Development of in vitro resistance to penicillin in a novel isolate of Streptococcus tigurinus

Journal of Microbiology and Infectious Diseases, 2017
Objectives: Streptococcus tigurinus is a new member of the Streptococcus mitis group. It causes various invasive infections. Its isolation from the oral cavity has been reported recently for the first time in our previous study.
Shree Dhotre, Basavraj S Nagoba, Milind Davane, Mahesh Dharne, Namdev Suryawanshi   +4 more
doaj   +1 more source

Prevalence of antibiotic resistance among bacteria isolates of lower respiratory tract infection in COPD Shahrekord Iran, 2005 [PDF]

, 2007
Background: Bacterial infection is one of the several important causes of exacerbations of chronic obstructive pulmonary disease (COPD). Antibiotic resistance has increased in all the major pathogens. The objective of this study was investigate frequency
Ganji, Forouzan., Imani, Reza., Rouhi-Boroujeni, Hamid.   +2 more
core  

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

Molecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute, Madeleine Birgersson, Paolo Ceriani, Margareta Wilhelm, Ourania N Kostopoulou   +4 more
wiley   +1 more source

Antibiotic resistance of Staphylococcus aureus associated with subclinical and clinical mastitis in Uruguay during an eight-year period

Austral Journal of Veterinary Sciences, 2017
Records of in vitro susceptibility tests performed between 2008 and 2015 were retrospectively reviewed in order to evaluate the dynamic profiles of possible changes in antimicrobial resistance of Staphylococcus aureus isolated from milk samples of cows ...
Rosario I. de los Santos, Pablo M. Zunino, Andrés D. Gil, Adolfo Laport, Darío J. Hirigoyen   +4 more
doaj   +1 more source

Drug Resistant Streptococcus pneumoniae (DRSP) in the Maltese Islands [PDF]

, 2004
The DRSP prevalence rate for the Maltese Islands was investigated. Consecutive samples were obtained, both from adults and children, from September 2000 through April 2002.
Barbara, Christopher, Cassar, Robert, Cuschieri, Paul, Micallef, Christianne   +3 more
core  

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer

Molecular Oncology, EarlyView.
Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov, Shiva Krishna Katkam, Zhefan Wang, Venkateshwar G. Keshamouni   +3 more
wiley   +1 more source

Penicillin allergy as an instrumental variable for estimating antibiotic effects on resistance

Nature Communications
Antibiotic resistance is influenced by prior antibiotic use, but precise causal estimates are limited. This study uses penicillin allergy as an instrumental variable (IV) to estimate the causal effect of antibiotics on resistance.
Yaki Saciuk, Daniel Nevo, Michal Chowers, Uri Obolski   +3 more
doaj   +1 more source