Results 101 to 110 of about 2,210,070 (253)

The enzymology of Streptococcus pneumoniae peptidoglycan polymerisation [PDF]

open access: yes
Bacterial cell survival depends on intact peptidoglycan, an extensive cell wall polymer of alternating N-acetylglucosamine and N-acetylmuramic acid residues, cross-linked by short peptides.
Abrahams, Katherine A.
core  

Myogenic Fusogen‐Engineered Lipid Nanoparticles Enhance mRNA Delivery in Skeletal Muscle

open access: yesAdvanced Functional Materials, EarlyView.
This study reports a biomimetic strategy of engineering full‐length Myomaker, a muscle‐specific fusogen, into lipid nanoparticles (LNPs) to harness the native myoblast fusion capability for skeletal muscle mRNA delivery. The resulting Mymk‐LNPs enhance transfection in differentiating myocytes and enable Cre‐mediated reporter activation in injured ...
Fangyu Zhang   +18 more
wiley   +1 more source

Tissue cages in calves for studies on pharmacokinetic/pharmacodynamic relationships of antimicrobials [PDF]

open access: yes, 2003
Knowledge on pharmacokinetic/pharmacodynamic (PK/PD) relationships of antimicrobials may assist in defining a dose that maximises effect while minimising side effects such as selection of resistance.
Greko, Christina
core   +1 more source

Heteroresistance to penicillin in Streptococcus pneumoniae

open access: yes, 2007
Heteroresistance to beta-lactam antibiotics has been mainly described for staphylococci, for which it complicates diagnostic procedures and therapeutic success.
Morand, Brigitte, Mühlemann, Kathrin
core   +1 more source

An Epigenetic Fate Converter Based on Nuclei‐Targeting Lipid Nanoparticles Drives Neuronal Programming of Stem Cells for Spinal Cord Repair

open access: yesAdvanced Functional Materials, EarlyView.
Schematic illustration of LNP‐MPG nuclei‐targeting delivery of HMW‐FGF2 promoting histone acetylation to regulate the fate of DPSCs and treat spinal cord injury. LNPs components include pHMW‐FGF2 plasmid, DSPC, Dlin‐MC3‐DMA, cholesterol, and PEG2000, and are modified with MPG to form HMW‐FGF2@LNP‐MPG (HLM). HLM nuclei‐targets DPSCs to deliver HMW‐FGF2,
Heng Zhou   +6 more
wiley   +1 more source

ارزیابی شیوع ژن‌های pbp1a، pbp2x و pbp2b در ایجاد مقاومت به پنی‌سیلین در سویه‌های Streptococcus pneumoniae جدا شده از بخش‌های مراقبت ویژه

open access: yesمجله دانشکده پزشکی اصفهان, 2012
Background: A major concern about S. pneumoniae is the emergence of resistance to antibiotics, especially to penicillin. The aim of this study was to assess the role of PBPs gene in penicillin resistance of S.
Mohammad Kargar   +2 more
doaj  

Microfluidic Nano‐Assembly of Red‐Blood‐Cell (RBC) Lipids and Components for Engineering Extracellular Vesicles

open access: yesAdvanced Healthcare Materials, EarlyView.
Engineered red blood cell‐derived extracellular vesicles (eRBCEVs) are synthesized via controlled microfluidic assembly from native RBC lipids, enabling tunable encapsulation of proteins, nucleic acids, nanoparticles, and viral vectors. The platform demonstrates reproducible nanoscale architecture, preserved membrane composition, and functional cargo ...
Chiranth K. Nagaraj   +23 more
wiley   +1 more source

Resistance of Escherichia coli Isolated from Water Sources on West Lombok Farms to Antibiotics

open access: yesMedia Kedokteran Hewan
Antibiotics are frequently used arbitrarily in livestock industry without regards for dosage or norms use. The administration of antibiotics to livestock can lead to a decline in their efficacy and contribute to the emergence of antibiotic resistance ...
Novarina Sulsia Ista'In Ningtyas   +3 more
doaj   +1 more source

Hydrogels Augmented With Artificial Sweeteners can Inhibit Multidrug‐Resistant Acinetobacter baumannii Growth and Biofilm Formation While Demonstrating Safety in Pre‐Clinical Pilot Human Trials

open access: yesAdvanced Healthcare Materials, EarlyView.
Using PVA–borax hydrogels as carriers for off‐the‐shelf artificial sweeteners to fight multidrug‐resistant A. baumannii. These soft, biocompatible hydrogels rapidly reduce bacterial viability within multidrug‐resistant A. baumannii biofilms by more than 99% within one hour and sustain antimicrobial activity over time, while demonstrating safety in both
Jie Han   +4 more
wiley   +1 more source

Nasopharyngeal carriage of penicillin-resistant Streptococcus pneumoniae in healthy children

open access: yesThe Turkish Journal of Pediatrics, 2007
Streptococcus pneumoniae carriage is a risk factor for the development of respiratory system infections and the spread of penicillin-resistant strains. The aim of this study was to investigate nasopharyngeal carriage of S.
Arzu Uzuner   +8 more
doaj  

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