Results 221 to 230 of about 4,016,959 (341)

A Tri‐Culture Heart‐on‐a‐Chip Platform With iPSC‐Derived Cardiac Cells for Predictive Cardiotoxicity Testing

Advanced Healthcare Materials, EarlyView.
This study presents the first entirely isogenic heart‐on‐chip, unifying cardiomyocytes, fibroblasts, and endothelial cells from a single iPSC source. The platform reveals a critical biological insight: the endothelium actively shields cardiac tissue from drug‐induced toxicity, challenging the predictive accuracy of conventional, avascular models for ...
Karine Tadevosyan, Jose Yeste, Mar Alvarez, Denise Marrero, Laura Casado‐Medina, Yvonne Richaud‐Patin, Olalla García‐Iglesias, Jagoda Litowczenko, Alba Morillas Garcia, Anton Guimerà, Xavi Illa, Rosa Villa, Angel Raya   +12 more
wiley   +1 more source

Epidemiology of Antimicrobial Residues and Phenotypic Resistance of Bacterial Isolates from Waste Milk on California Dairies. [PDF]

Microorganisms
Mihreteab Y, Okello E, Pandey P, Abdelfattah E, Ekong PS, Sheedy D, ElAshmawy WR, Karle BM, Black RA, Williams DR, Aly SS.   +10 more
europepmc   +1 more source

Emergence of macrolide and penicillin resistance among invasive pneumococcal isolates in Germany.

Journal of Antimicrobial Chemotherapy, 2002
R. Reinert, A. Al-Lahham, M. Lemperle, Christoph Tenholte, C. Briefs, Stefan Haupts, H. Gerards, R. Lütticken   +7 more
semanticscholar   +1 more source

Tuning the Testicular Microenvironment for Enhancing Human Sertoli Cells Maturation and Functionality In Vitro

Advanced Healthcare Materials, EarlyView.
An in vitro testicular model is developed by generating connective tissue equivalents from human dermal fibroblast‐derived microtissues and coupling them with human Sertoli cells or human Sertoli cell spheroids. This engineered microenvironment supports Sertoli cell maturation and functionality, providing a promising platform for studying human ...
Annachiara Scalzone, Giorgia Imparato, Chiara Ausilio, Valentina Mollo, Paolo Antonio Netti   +4 more
wiley   +1 more source

Pan-European analysis shows stable, low antimicrobial resistance in most bovine and porcine respiratory tract pathogens. [PDF]

Front Microbiol
de Jong A, Temmerman R, Rose M, Simjee S, El Garch F, VetPath Study Group.   +5 more
europepmc   +1 more source

Overexpression of the MtrC-MtrD-MtrE Efflux Pump Due to an mtrR Mutation Is Required for Chromosomally Mediated Penicillin Resistance in Neisseria gonorrhoeae

Journal of Bacteriology, 2002
Wendy L. Veal, R. Nicholas, W. Shafer
semanticscholar   +1 more source

CORE: Cholesterol Altered Lipid Nanoparticles for Splenic Expression of mRNA Payloads

Advanced Healthcare Materials, EarlyView.
In this paper researchers introduce CORE LNPs, a new class of lipid nanoparticles engineered to redirect mRNA expression away from the liver and into the spleen, a key immune organ. By combining chemical design with computational tools, they created cholesterol analogs that enable precise spleen‐targeted expression, providing greater applications for ...
Eshan A. Narasipura, Vincent Fung, Rachel VanKeulen‐Miller, Palas B. Tiwade, Owen S. Fenton   +4 more
wiley   +1 more source

Pre and post introduction of pneumococcal conjugate vaccines in children in Eastern Mediterranean Region and effect on antimicrobial resistance, a narrative review. [PDF]

Front Microbiol
Saleh BM, Mere O, Elmrayed S.
europepmc   +1 more source

Effect of penicillin resistance of Streptococcus pneumoniae on the presentation, prognosis, and treatment of pneumococcal endocarditis in adults.

Clinical Infectious Diseases, 2002
E. Martinez, J. Miro, B. Almirante, J. Aguado, P. Fernández‐Viladrich, M. Fernández-Guerrero, J. L. Villanueva, F. Dronda, A. Moreno-Torrico, M. Montejo, P. Llinares, J. Gatell   +11 more
semanticscholar   +1 more source

Engineering Resatorvid‐Loaded Sub‐Microgels of Epigallocatechin‐3‐gallate/Hyaluronic Acid to Treat Acute Lung Injury

Advanced Healthcare Materials, EarlyView.
This study presents HAEP@Res sub‐microgels as a lung‐targeted delivery system integrating antioxidant activity with anti‐inflammatory therapy. The sub‐microgels demonstrate excellent biocompatibility, efficiently scavenge intracellular ROS, and downregulate pro‐inflammatory cytokines and genes in a Bleo‐induced ALI mouse model. These findings highlight
Bo Liu, Olawale Alimi Alimi, Benjamin Stearnes, Svetlana Romanova, Brady J. Sillman, Mena Asha Krishnan, Kristina Bailey, Benson J. Edagwa, Huanhuan Joyce Chen, Han‐jun Wang, Bin Duan   +10 more
wiley   +1 more source