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A penicillin-resistant pneumococcus

The Journal of Pediatrics, 1978
STREPTOCOCCUS PNEUMONIAE has been almost uniformly sensitive to pen!cillin, With minimum inhibitory concentrations of 0.05 Fg/m 1 or less. In 1967, the first pariially resistant strain with an MIC of 0.6/~g/ml, was reported from Sydney, Australia. Since then there have been reports of pneumococci having increased resistance to penicillin, with MICs ...
K L, Cates   +8 more
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Penicillin-resistant pneumococcus

Irish Journal of Medical Science, 1988
Penicillin resistant pneumococci are now described world wide, with increasing recognition of the clinical implications of infection with these strains and the laboratory methods required for their identification. In presenting such a case, we suggest thatin vitro sensitivity testing with oxacillin discs affords the best method for detection of ...
G D, Corcoran   +4 more
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Penicillin Resistance and Aminoglycoside-Penicillin Synergy in Enterococci

Chemotherapy, 2009
Susceptibility to penicillin, vancomycin, imipenem, streptomycin, kanamycin and gentamicin was tested in 130 clinical isolates of Enterococcus spp. by an agar dilution method. Penicillin resistance (MIC > 8 mg/l) was only observed among strains of Enterococcus faecium and Enterococcus raffinosus.
H A, Lopardo, M E, Venuta, E A, Rubeglio
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Penicillin-resistant pneumococci

Drugs of Today, 1998
Penicillin-resistant pneumococci are of concern in respiratory tract infections. Currently, nearly all of the "penicillin resistance" to Streptococcus pneumoniae is relative resistance which indicates decreased antibiotic activity in terms of the MIC, but these isolates are still susceptible to sensitive antibiotics given in the usual/high doses.
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Penicillin-resistant pneumococci

Journal of Hospital Infection, 1991
Penicillin-resistant pneumococci were first reported in Australia in 1967 and appeared in the UK in 1976. Their prevalence is increasing but varies greatly worldwide. The mechanism of resistance lies in the alteration of penicillin-binding proteins. Penicillin-resistant strains are often also resistant to a variety of non-beta-lactam antibiotics.
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Penicillin-Resistant Pneumococcus and Meningitis

Annals of Internal Medicine, 1983
Excerpt To the editor: Isolates ofStreptococcus pneumoniaeeither relatively resistant (minimal inhibitory concentration, 0.1 to 1.0 µg/mL) or fully resistant to penicillin (4 to 8 µg/mL) have been ...
G M, Caputo   +3 more
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Resistant penicillin-binding proteins

Cellular and Molecular Life Sciences CMLS, 1998
Low-affinity penicillin-binding proteins (PBPs), which participate in the beta-lactam resistance of several pathogenic bacteria, have different origins. Natural transformation and recombination events with DNA acquired from neighbouring intrinsically resistant organisms are responsible for the appearance of mosaic genes encoding two or three low ...
R, Hakenbeck, J, Coyette
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Screening pneumococci for penicillin resistance

Journal of Clinical Microbiology, 1986
Eighty-four pneumococci with various MICs of penicillin (38 with MICs of less than or equal to 0.06 micrograms/ml [susceptible], 35 with MICs of 0.12 to 1.0 micrograms/ml [relatively resistant], and 11 with MICs of greater than 1.0 micrograms/ml [resistant] ) were screened by a disk diffusion test using oxacillin and methicillin to see how well they ...
J M, Swenson, B C, Hill, C, Thornsberry
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RESISTANCE TO PENICILLIN

Journal of the American Medical Association, 1951
To the Editor: —In two editorials in the April 21 issue ofThe Journal of the American Medical Association, emphasis is directed to the emergence of penicillin-resistant bacterial strains, inferentially warning the medical world that ominous clinical problems may develop.
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