Results 321 to 330 of about 3,443,339 (411)

Multiple antimicrobial resistance indices of Staphylococcus aureus from the nares of goats and slaughterhouse attendants in Kampala city, Uganda- a cross sectional study. [PDF]

BMC Microbiol
Muwonge KM, Ndagire H, Mulindwa J, Twesigye CK.   +3 more
europepmc   +1 more source

FGF2 Mediated USP42‐PPARγ Axis Activation Ameliorates Liver Oxidative Damage and Promotes Regeneration

Advanced Science, EarlyView.
USP42 is identified as a novel DUB of PPARγ in hepatocytes. USP42 mediated PPARγ deubiquitylation determines its transcriptional preference on proliferative and redox balance genes. USP42 knockdown exacerbates liver damage and delays regeneration. FGF2 is the upstream signal that initiates and activates the USP42‐PPARγ axis.
Nanfei Yang, Qiang Tian, Zhenli Lei, Shuxin Wang, Nan Cheng, Zhen Wang, Xianqin Jiang, Xuqun Zheng, Wenjing Xu, Minyan Ye, Longwei Zhao, Meiyun Wen, Jianlou Niu, Weijian Sun, Pingping Shen, Zhifeng Huang, Xiaokun Li   +16 more
wiley   +1 more source

The Evolution of the Antimicrobial Resistance of Streptococcus pneumoniae in Tunisia: A Multicentric Analysis over Two Decades (2000-2019). [PDF]

Antibiotics (Basel)
Ben Ayed N, Gargouri O, Mhimdi S, Smaoui F, Mhiri E, Kanzari L, Zribi M, Maalej Mezghanni S, Ktari S, Meftah K, Mohamed N, Zaghden H, Bahri O, Besbes S, Achour W, Slim L, Boutiba I, Smaoui H, Hammami A.   +18 more
europepmc   +1 more source

Genome‐Wide Silencer Screening Reveals Key Silencer Modulating Reprogramming Efficiency in Mouse Induced Pluripotent Stem Cells

Advanced Science, EarlyView.
This study utilized Ss‐STARR‐seq to construct a genome‐wide silencer map of mouse cells and elucidated the fundamental characteristics of these silencers. These silencers exist in a cell‐specific manner and exhibit unique epigenetic modifications. Through functional experiments, we also discovered that these silencers can regulate gene expression and ...
Xiusheng Zhu, Lei Huang, Guoli Li, Biao Deng, Xiaoxiao Wang, Hu Yang, Yuanyuan Zhang, Qiuhan Wen, Chao Wang, Jingshu Zhang, Yunxiang Zhao, Kui Li, Yuwen Liu   +12 more
wiley   +1 more source

High Percentages of Resistance to Tetracycline and Penicillin and Reduced Susceptibility to Azithromycin Characterize the Majority of Strain Types of Neisseria gonorrhoeae Isolates in Cuba, 1995???1998

, 2003
Jorge Sosa, Sandra Ramírez‐Arcos, Martha Ruben, Hui Li, Rafael Llanes, Aliña Llop, Jo‐Anne R. Dillon   +6 more
openalex   +1 more source

α‐Synuclein Pathology Spreads in a Midbrain–Hindbrain Assembloid Model

Advanced Science, EarlyView.
A novel midbrain–hindbrain assembloid model demonstrates the spread of α‐synuclein pathology, a hallmark of Parkinson's disease, mimicking Braak's hypothesis. This model reveals how pathology propagates from the hindbrain to the midbrain, inducing synaptic changes and early signs of neuronal vulnerability. It offers an innovative platform for exploring
Gemma Gomez‐Giro, Daniela Frangenberg, Daniela Vega, Alise Zagare, Kyriaki Barmpa, Paul M. A. Antony, Graham Robertson, Rahman Sabahi‐Kaviani, Kristian Haendler, Nathalie Kruse, Florentia Papastefanaki, Rebecca Matsas, Malte Spielmann, Regina Luttge, Jens C. Schwamborn   +14 more
wiley   +1 more source

Prevalence of Variant GTR^I<i>Staphylococcus aureus</i> Isolated from Dairy Cow Milk Samples in the Alpine Grazing System of the Aosta Valley and Its Association with AMR and Virulence Profiles. [PDF]

Antibiotics (Basel)
Monistero V, Hossain D, Fusar Poli S, de Medeiros ES, Cremonesi P, Castiglioni B, Biscarini F, Graber HU, Mochettaz G, Ganio S, Gazzola A, Addis MF, Roullet C, Barberio A, Deotto S, Biasio L, Ulloa F, Galanti D, Bronzo V, Moroni P.   +19 more
europepmc   +1 more source

ZMYND8 Reads H3K36me2 to Activate CEBPE Transcription and Suppress Multiple Myeloma Progression through the Inhibition of Adaptive UPR Pathways

Advanced Science, EarlyView.
Zinc‐finger MYND‐type‐containing 8 (ZMYND8) activates the transcription of CCAAT/enhancer‐binding protein epsilon by recognizing dimethylation of lysine 36 in histone H3 through its Pro‐Trp‐Trp‐Pro domain, thereby inhibiting adaptive unfolded protein response pathways to suppress the proliferation and invasion of multiple myeloma (MM) cells ...
Jiaxuan Xu, Xiaoqing Dong, Yue Peng, Jie Yan, Peipei Xu, Feiyu Li, Suwen Zhang, Lanxin Chen, Xingjun Meng, Kangning Wang, Mengying Xing, Wenyang Li, David C. S. Huang, Quan Zhao, Bing Chen   +14 more
wiley   +1 more source

A case of penicillin-resistant group B Streptococcus isolated from a patient in the UK. [PDF]

J Antimicrob Chemother
McGuire E, Ready D, Ellaby N, Potterill I, Pike R, Hopkins KL, Guy RL, Lamagni T, Mack D, Scobie A, Warren S, Brown CS, Coelho J.   +12 more
europepmc   +1 more source

Nanotherapy for Neural Retinal Regeneration

Advanced Science, EarlyView.
Nanotechnology enhances ophthalmic treatments by improving drug delivery and regenerating ocular tissues, combating vision loss from retinal diseases through innovative nano‐systems. This review outlines ocular anatomy, pathology, immune microenvironment, and barriers, detailing nanocarrier characteristics, classification, and preparation methods, and ...
Chuyao Yu, Li Dong, Yujia Lv, Xuhan Shi, Ruiheng Zhang, Wenda Zhou, Haotian Wu, Heyan Li, Yitong Li, Zhou Li, Dan Luo, Wen‐Bin Wei   +11 more
wiley   +1 more source