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Intrinsic Penicillin Resistance in Enterococci
Microbial Drug Resistance, 1996Penicillin resistance development in enterococci has been associated with overproduction of a low-affinity penicillin-binding protein (PBP) that is a normal component of the PBP pattern of these bacteria and is apparently able to substitute the functions of the other PBPs. In resistant mutants of Enterococcus hirae ATCC 9790 the low-affinity PBP (PBP5)
FONTANA, Roberta +3 more
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Penicillin-resistant pneumococcus
Irish Journal of Medical Science, 1988Penicillin resistant pneumococci are now described world wide, with increasing recognition of the clinical implications of infection with these strains and the laboratory methods required for their identification. In presenting such a case, we suggest thatin vitro sensitivity testing with oxacillin discs affords the best method for detection of ...
G. D. Corcoran +4 more
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A penicillin-resistant pneumococcus
The Journal of Pediatrics, 1978STREPTOCOCCUS PNEUMONIAE has been almost uniformly sensitive to pen!cillin, With minimum inhibitory concentrations of 0.05 Fg/m 1 or less. In 1967, the first pariially resistant strain with an MIC of 0.6/~g/ml, was reported from Sydney, Australia. Since then there have been reports of pneumococci having increased resistance to penicillin, with MICs ...
Maura O'Leary +8 more
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Evaluation and Management of Penicillin Allergy: A Review
Journal of the American Medical Association (JAMA), 2019Importance &bgr;-Lactam antibiotics are among the safest and most effective antibiotics. Many patients report allergies to these drugs that limit their use, resulting in the use of broad-spectrum antibiotics that increase the risk for antimicrobial ...
E. Shenoy +3 more
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Comparative genome analysis of high-level penicillin resistance in Streptococcus pneumoniae.
Microbial Drug Resistance, 2009Streptococcus pneumoniae strains with very high levels of penicillin resistance (minimum inhibitory concentration [MIC] >or=8 microg/ml) emerged in the 1990 s.
A. Tait-Kamradt +2 more
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Penicillin Resistance and Autolysis in Enterococci
Microbial Drug Resistance, 1996Comparison of several cell wall-related properties of the ATCC 9790 strain and the R40 strain, a penicillin-resistant, PBP5 overproducing strain, and Rev14, a penicillin-hypersensitive, PBP5-deficient strain, is consistent with a role of the genetic element, psr, in the global regulation of lysozyme sensitivity, autolytic capacity, and wall-rhamnose ...
DANEO MOORE L. +3 more
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Screening pneumococci for penicillin resistance [PDF]
Journal of Clinical Microbiology, 1986 Eighty-four pneumococci with various MICs of penicillin (38 with MICs of less than or equal to 0.06 micrograms/ml [susceptible], 35 with MICs of 0.12 to 1.0 micrograms/ml [relatively resistant], and 11 with MICs of greater than 1.0 micrograms/ml [resistant] ) were screened by a disk diffusion test using oxacillin and methicillin to see how well they ...
Clyde Thornsberry +2 more
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Penicillin-resistant pneumococci
Journal of Hospital Infection, 1991Penicillin-resistant pneumococci were first reported in Australia in 1967 and appeared in the UK in 1976. Their prevalence is increasing but varies greatly worldwide. The mechanism of resistance lies in the alteration of penicillin-binding proteins. Penicillin-resistant strains are often also resistant to a variety of non-beta-lactam antibiotics.
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