Results 71 to 80 of about 4,016,959 (341)

Antibiotic prescribing by general dental practitioners in the Greater Glasgow Health Board, Scotland [PDF]

, 2000
OBJECTIVE: To investigate antibiotic prescribing patterns by general dental practitioners (GDPs) in the Greater Glasgow Health Board Area, Scotland. STUDY DESIGN: A 10% sample of prescriptions were selected at random from 35,545 prescriptions written by ...
Bagg, J., Roy, K.
core   +1 more source

Combining antibody conjugates with cytotoxic and immune‐stimulating payloads maximizes anti‐cancer activity

Molecular Oncology, EarlyView.
Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang, Dong Jun Koo, Peter M. Tessier, Greg M. Thurber   +3 more
wiley   +1 more source

Bacterial Resistance to Penicillin G by Decreased Affinity of Penicillin-Binding Proteins: A Mathematical Model

Emerging Infectious Diseases, 2003
Streptococcus pneumoniae and Neisseria meningitidis have very similar mechanisms of resistance to penicillin G. Although penicillin resistance is now common in S. pneumoniae, it is still rare in N. meningitidis.
L. Temime, P.Y. Boëlle, P. Courvalin, D. Guillemot   +3 more
doaj   +1 more source

Detection of the United States Neisseria meningitidis urethritis clade in the United Kingdom, August and December 2019 - emergence of multiple antibiotic resistance calls for vigilance. [PDF]

, 2020
Since 2015 in the United States (US), the US Neisseria meningitidis urethritis clade (US_NmUC) has caused a large multistate outbreak of urethritis among heterosexual males.
Borrow, R, Brooks, A, Campbell, H, Campbell, L, Fifer, H, Gray, S, Hughes, G, Ladhani, SN, Lekshmi, A, Lucidarme, J, Ramsay, ME, Rayment, M, Schembri, G   +12 more
core   +2 more sources

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

Antibiotic resistance of Staphylococcus aureus isolated from the oral cavity of paraguayan participants from Coronel Oviedo, year 2021

Memorias del Instituto de Investigaciones en Ciencias de la Salud
A cross-sectional study was carried out to identify the resistance profile of Staphylococcus aureus colonizing the oral cavity of patients. Sampling was carried out with sterile swabs. Mannitol-positive colonies were cultured on blood agar, identifying S.
Ulises Villasanti Torales, Julieta Mendez, Jazmín Servin, Marylet Rodriguez, Andrea Villalba, Analia Ortiz, Pablo Franco   +6 more
doaj   +1 more source

Attributable deaths and disability-adjusted life-years caused by infections with antibiotic-resistant bacteria in the EU and the European Economic Area in 2015: a population-level modelling analysis [PDF]

, 2018
Background: Infections due to antibiotic-resistant bacteria are threatening modern health care. However, estimating their incidence, complications, and attributable mortality is challenging.
Abu Sin, Muna, Andrasevic, Arjana Tambic, Aracil, Belen, Asensio, Angel, Billstrom, Hanna, Borg, Michael A., Budimir, Ana, Burns, Karen, Canica, Manuela, Cassini, Alessandro, Catry, Boudewijn, Cecchini, Michele, Coignard, Bruno, Colomb-Cotinat, Melanie, Daikos, George L., de Greeff, Sabine C., Deptula, Aleksander, Devleesschauwer, Brecht, Dobreva, Elina Georgieva, Dsstat, Patrizio Pezzotti, Dumpis, Uga, Eckmanns, Tim, Elstrom, Petter, Fernandes, Paulo Andre, Gagliotti, Carlo, Gikas, Achilleas, Guolaugsson, Olafur, Hajdu, Agnes, Haller, Sebastian, Hogberg, Liselotte Diaz, Hopkins, Susan, Hoxha, Ana, Hryniewicz, Waleria, Ivanov, Ivan Nikolaev, Ivanova, Marina, Jalava, Jari, Johnson, Alan, Klavs, Irena, Koek, Mayke B. G., Kolman, Jana, Kontopidou, Flora, Korosec, Ales, Kretzschmar, Mirjam E., Kristinsson, Karl G., Larsson, Sofie, Latour, Katrien, Litvova, Slavka, Liuimiene, Agne, Lyytikainen, Outi, Manageiro, Vera, Martin, Pille, Mertens, Karl, Monen, Jos C. M., Monnet, Dominique L., Murchan, Stephen, Nogueira, Paulo Jorge, Oliveira, Tiago Cravo, Olsen, Stefan Schytte, Ouakrim, Driss Ait, Paphitou, Niki, Perez-Vazquez, Maria, Perrin, Monique, Plachouras, Diamantis, Popescu, Gabriel Adrian, Quattrocchi, Annalisa, Reilly, Jacqui S., Schreterova, Eva, Serban, Roxana Ioana, Simonsen, Gunnar Skov, Sonksen, Ute Wolff, Soprek, Silvija, Stefkovicova, Maria, Strauss, Reinhild, Struelens, Marc J., Struyf, Thomas, Suetens, Carl, Toth, Akos, Tsiodras, Sotirios, Zabicka, Dorota, Zemlickova, Helena   +79 more
core   +6 more sources

Image-based dynamic phenotyping reveals genetic determinants of filamentation-mediated beta-lactam tolerance [PDF]

, 2020
Antibiotic tolerance characterized by slow killing of bacteria in response to a drug can lead to treatment failure and promote the emergence of resistance.
Camacho, Rafael, Fauvart, Maarten, Franke, Sabine, Hofkens, Johan, Marchal, Kathleen, Michielsen, Jan, Weytjens, Bram, Wilmaerts, Dorien, Zahir, Taiyeb   +8 more
core   +2 more sources

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Rapid Determination of Benzylpenicillin Resistance in Staphylococcus aureus Bacteraemia Model

Infection and Drug Resistance, 2020
JeongWoo Kang,1,2 Md Akil Hossain,1 Hae-chul Park,1 Yong-sang Kim,1 Sung-won Park,1 Tae-Wan Kim2 1Veterinary Drugs & Biologics Division, Animal and Plant Quarantine Agency (APQA), Gimcheon-si, Gyeongsangbuk-do, Republic of Korea; 2Department of ...
Kang J, Hossain MA, Park H, Kim Y, Park S, Kim TW   +5 more
doaj