Results 101 to 110 of about 115,418 (261)
Journal of Applied Toxicology, EarlyView.ABSTRACT In this study, ten novel compounds (IPH1–IPH10) were designed by integrating three pharmacophores (isatin, piperazine, and hydrazone) commonly found in the molecular structures of anticancer agents. The target molecules were obtained by the reaction of in‐house prepared 4‐(4‐(pyridin/pyrimidin‐2‐yl)piperazin‐1‐yl)benzohydrazide with various ...
Semiha Köprü +3 more
wiley +1 more source
Cellular properties of convulsant-treated rat neo-cortical neurons during postnatal development [PDF]
, 1989 Hablitz, John H. +3 more
core +1 more source
Journal of the Science of Food and Agriculture, EarlyView.Abstract BACKGROUND Hazelnuts and foods produced using hazelnuts are consumed with pleasure, but it is important to evaluate the waste generated during hazelnut processing and determine their usage methods. RESULTS This study was conducted to determine the changes in bioactive components, bioaccessibility and antidiabetic activity of nanoparticles ...
Mehmet Ali Temiz, Emine Okumus
wiley +1 more source
The Kaohsiung Journal of Medical Sciences, EarlyView.ABSTRACT The prevalence of postmenopausal osteoporosis (PMOP) has been steadily increasing. Ferroptosis has been recognized as a critical factor influencing the bone‐forming ability of bone marrow mesenchymal stem cells (BMSCs). Valproic acid (VPA), an HDAC inhibitor, has been suggested to play a role in regulating osteoporosis development; however ...
Qing‐Song Gu +8 more
wiley +1 more source
Macromolecular Rapid Communications, EarlyView.Linear polyglycerol is proposed as a PEG‐alternative in mRNA‐loaded lipid nanoparticles to limit activation of anti‐PEG antibodies and reduce immunogenicity. Resulting nanoparticles may provide similar gene delivery capabilities, while preventing binding of anti‐PEG antibodies compared to PEGylated counterparts.
Yara Ensminger +8 more
wiley +1 more source
Macromolecular Rapid Communications, EarlyView.We have developed a thermoresponsive microgel system for the selective enrichment of hyaluronic acid‐binding tumor cells. By modulating the adhesion on the microgel surface via temperature changes from 37°C to 30°C, we demonstrate a novel proof‐of‐principle for separating these tumor cell from white blood cells, which has potential applications in ...
Melanie Schmidt +8 more
wiley +1 more source
Farnesoid X receptor prevents hyperuricemia via activating ATP‐binding cassette subfamily G member 2
Rheumatology &Autoimmunity, EarlyView.Farnesoid X receptor (FXR) activation reduces serum uric acid levels by upregulating the intestinal urate transporter ATP‐binding cassette subfamily G member 2 (ABCG2). These findings uncover a novel metabolic pathway for urate excretion and suggest that FXR agonists (e.g., obeticholic acid), represent a promising therapeutic strategy for the treatment
Rui Li +5 more
wiley +1 more source
2D van der Waals System Integrated with Targeting Radio‐Diagnostic and Imaging Functions
Small, EarlyView.Layered double hydroxide (LDH) nanoplates were engineered for tumor‐targeted imaging and therapy. By exploiting folate receptor (FR) expression levels, the system achieves selective tumor accumulation and high‐resolution dual PET/fluorescence (PET/FL) imaging.
Sairan Eom +6 more
wiley +1 more source
In Vitro Reconstruction of Axonal Heat Sensing with a Photothermal Nerve‐on‐a‐Chip
Small, EarlyView.A photothermal nerve‐on‐a‐chip platform is presented that enables precise, localized heating of sensory axons with simultaneous electrical recording. The system reveals millisecond‐scale dynamics of heat‐evoked neural activity and provides a new approach to study how temperature‐dependent ion channel behavior is translated into axonal firing.
Koji Sakai +6 more
wiley +1 more source
Temporal trends of inpatient oral penicillin challenges in a U.S. veteran cohort with a recorded penicillin allergy. [PDF]
Antimicrob Steward Healthc EpidemiolArasaratnam RJ, Vu C, Alvarez CA.
europepmc +1 more source