Results 131 to 140 of about 10,097,740 (265)

Persistent high diphtheria positivity in North India: Evidence from a tertiary hospital-based study, 2007-2021. [PDF]

Indian J Med Res
Sharma NC, Ranjan R, Sharma K, Ramamurthy T, Murhekar MV, Ahmad V.   +5 more
europepmc   +1 more source

The Impact of Common Medications on Male Fertility: An Updated Systematic Review

Andrology, EarlyView.
ABSTRACT Background Compared with those of cytotoxic treatments, the potential effects of common medications on the fertility of men trying to conceive currently or planning to conceive in the future are less well described. The use of common medications may modify the gonadotropic axis, spermatogenesis, and epididymal maturation or alter male ...
Lina Jebli, Salomé Gallissian, Roxanne Barèges, Félicia Fournier, Catherine Metzler‐Guillemain, Ségolène Prades, Fanny Magnan‐Sebag, Jeanne Perrin   +7 more
wiley   +1 more source

Targeting hexokinase 2 to induce breast cancer cell senescence

British Journal of Pharmacology, EarlyView.
Background and Purpose Hexokinase 2 (HK2) is a key enzyme linked to high tumour cell proliferation. Its inhibitors such as 3‐bromopyruvic acid (3‐BP) induce cancer cell death, highlighting HK2 modulation as potential anti‐cancer treatment. However, standard chemotherapies often cause the emergence of senescent cancer cells, which goes along with cell ...
Helmut Bischof, Katarina Cisarova, Sandra Burgstaller, Mia Schwerer, Markus Absenger‐Novak, Philipp J. Jost, Roland Malli, Wolfgang F. Graier, Robert Lukowski   +8 more
wiley   +1 more source

Atrial natriuretic peptide counteracts aldosterone secretion by preventing acute angiotensin II‐induced cAMP signalling

British Journal of Pharmacology, EarlyView.
Background and Purpose Aldosterone plays a key role in blood pressure and volume regulation. Enhanced aldosterone secretion contributes to cardiovascular and renal diseases. Therefore, inhibitors of aldosterone receptors and synthase are essential drugs for the treatment of hypertension and heart failure.
Sanika Mohagaonkar, Egor B. Skryabin, Bettina M. Buchholz, Michaela Kuhn, Celso E. Gomez‐Sanchez, Stepan Gambaryan, Viacheslav O. Nikolaev   +6 more
wiley   +1 more source

Mislocalization of PBPs in <i>Staphylococcus aureus gdpP</i> mutant contributes to β-lactam resistance and surface protein cross-wall trafficking. [PDF]

Microbiol Spectr
Jia Y, Zhang R, Scaffidi SJ, Yu W.
europepmc   +1 more source

Direct evidence implicating the asymmetrical dimethylarginine (ADMA)‐dimethylarginine dimethylaminohydrolase 1 (DDAH1) pathway in cerebrovascular dysfunction and stroke pathogenesis in mice

British Journal of Pharmacology, EarlyView.
Abstract Background and Purpose Asymmetrical dimethylarginine (ADMA) is an endogenous inhibitor of nitric oxide synthase (NOS), whereas dimethylaminohydrolase 1 (DDAH1) is primarily responsible for its metabolism. However, the roles of DDAH1 in cerebrovascular regulation are poorly understood. Furthermore, despite evidence that elevated ADMA levels are
Arun Flynn, Alexandra Riddell, Ashton Bernard, Jennifer Haggarty, Stefan Weidt, Jawza Alenazi, Erika Trabold, Delyth Graham, Laura B. Dowsett, James Leiper, Alyson A. Miller   +10 more
wiley   +1 more source

Identification of targets for high penicillin G production in an industrial strain of Penicillium rubens. [PDF]

Appl Microbiol Biotechnol
Dou K, Pan Y, Yao Y, Tian X, Guo N, Liu G.   +5 more
europepmc   +1 more source

Politicized Medicine in the GDR: The Example of the Closed Venereology Ward at Dresden‐Friedrichstadt Hospital

JDDG: Journal der Deutschen Dermatologischen Gesellschaft, EarlyView.
Summary Background and Objectives Closed venereology wards existed in both Western and Eastern European dictatorships. These institutions isolated, disciplined, and “educated” individuals with Sexually Transmitted Infections (STI) or suspected infections.
Maximilian Schochow, Florian Steger
wiley   +1 more source

MicroRNA-sensing plasmid system for dynamic control of functional ion channel expression. [PDF]

Mol Ther Nucleic Acids
Geuter J, Austin TT, Corke J, Tian N, Brown J, Schorge S, Morris G.   +6 more
europepmc   +1 more source

Virtual screening of GPR37L1 small-molecule modulator for neuropathic pain. [PDF]

Pain
Chandra S, Xu J, Bang S, Guo R, Ji RR.
europepmc   +1 more source