Results 141 to 150 of about 333,681 (346)
Advanced Science, EarlyView.PBRM1 ranks as the second most commonly mutated gene in ccRCC. This study reveals that PBRM1 loss promotes an immunosuppressive microenvironment by elevating M2 TAMs via the KDM5C–IL‐6 axis. These M2 TAMs, along with CAFs, form a barrier that excludes CD8+ T cells. Targeting IL‐6 synergizes with anti‐PD1 therapy, offering a promising strategy for PBRM1‐
Wenjiao Xia +14 more
wiley +1 more source
Injectable agents for the induction of Peyronie’s disease in model rats: a comparative study
Asian Journal of AndrologyPeyronie’s disease (PD) is a disorder characterized by fibrous plaque formation in the penile tissue that leads to curvature and complications in advanced stages.
Guang-Jun Du +7 more
doaj +1 more source
Penile Fracture with Associated Urethral Rupture
Case Reports in Medicine, 2010 Penile fracture of the erect penis is an uncommon but emergent urological trauma. Potential outcomes include erectile dysfunction, penile curvature, and urethral injury. Treatment is emergent surgical repair. We present the case of a 42-year-old man with
Nicholas A. Boncher +4 more
doaj +1 more source
Qualitative Analysis of the Content Found in Online Discussion Boards for Urethral Stricture Disease and Urethroplasty. [PDF]
, 2019 ObjectiveTo describe the patient experience and chief concerns with urethroplasty to improve physician understanding and patient education. Online discussion boards allow patients with urethral stricture disease (USD) to connect with other USD patients ...
Baradaran, Nima +6 more
core +1 more source
Advanced Science, EarlyView.Elevated exogenous palmitic acid promotes the S‐palmitoylation of SRPK1 in endothelial cells, a dynamic process governed by ZDHHC24 and APT1. This post‐translational modification strengthens the interaction between SRPK1 and the E3 ubiquitin ligase MIB1, thereby facilitating the proteasomal degradation of SRPK1.
Xiao‐Hui Tan +11 more
wiley +1 more source
Nursing Care and Parents Contribution in the Care of their Childern with Hypospadias [PDF]
, 2010 The term hypospadias is derived from the Greek language and refers to the pathological condition of urethra, which the vestibule, by the time of embryology is imperfect. Approximately 1 to 300 male births appear this problem. The aim of this study is the
Dimitra Zioga +2 more
core
Long-term patient satisfaction after surgical correction of penile curvature via tunical plication [PDF]
, 2007 Álvaro Páez +5 more
openalex +1 more source
Engineered GM1 Intersects Between Mitochondrial and Synaptic Pathways to Ameliorate ALS Pathology
Advanced Science, EarlyView.Amyotrophic Lateral Sclerosis (ALS) is a fatal neurodegenerative disease driven by genetic and molecular disruptions affecting energy balance, protein homeostasis, and stress responses in nerve cells. Studies using human and rodent models identified convergent defects in mitochondria and synaptic function.
Federica Pilotto +11 more
wiley +1 more source
International journal of impotence research, 2022 N. Schifano +14 more
semanticscholar +1 more source
Advanced Science, EarlyView.This study presents a two‐color FCCS and coincident‐burst analysis platform to quantify actin cargo in dual‐labeled EVs secreted from hiPSCs. The approach tracks secretion dynamics, confirms actin loading, and measures EV size and cargo number, offering insights into cytoskeletal disruption and neuronal differentiation relevant to neurodegenerative ...
Dang Du Nguyen +4 more
wiley +1 more source