Results 181 to 190 of about 9,528 (278)

Barriers to adoption of biosimilar insulins in Europe: A mixed‐methods study

Diabetes, Obesity and Metabolism, Volume 27, Issue 11, Page 6715-6726, November 2025.
Abstract Background Despite the introduction of biosimilar insulins to improve affordability and enhance patient access, their adoption remains limited in Europe. Objectives This study aims to (i) provide an up‐to‐date overview of EMA‐approved insulin products and their reimbursement status across selected European countries, and (ii) explore the key ...
Elif Car, Garm Habets, Arnold G. Vulto, Lutz Heinemann, Isabelle Huys, Steven Simoens   +5 more
wiley   +1 more source

Bifocal <i>β</i>-hCG-secreting CNS Germinoma in a 13-Year-Old Boy: Clinical-Biochemical Pubertal Discordance and Long-Term Outcome. [PDF]

Case Rep Pediatr
Nicolescu CR, Doulet ST, Bazus L, Stephan JL.   +3 more
europepmc   +1 more source

ACSS2 involved in acetyl‐CoA synthesis regulates skeletal muscle function

FEBS Letters, Volume 599, Issue 19, Page 2817-2827, October 2025.
The enzyme acyl‐coenzyme A synthetase short‐chain family member‐2 (ACSS2) catalyzes the conversion of acetate to acetyl‐CoA, but its function in skeletal muscle is unclear. We studied ACSS2 deficiency in mouse and fly models. Skeletal muscle from the mouse model showed atrophic fibers, excess lipid, and depleted NADH.
Mekala Gunasekaran, Gloriana Campos, Natalya M. Wells, Khanhlinh Lambuu, Isabelle Draper, Christina A. Pacak, Peter B. Kang   +6 more
wiley   +1 more source

TRPM8 levels determine tumor vulnerability to channel agonists

Molecular Oncology, Volume 19, Issue 10, Page 2905-2920, October 2025.
TRPM8 is a Ca2+ permissive channel. Regardless of the amount of its transcript, high levels of TRPM8 protein mark different tumors, including prostate, breast, colorectal, and lung carcinomas. Targeting TRPM8 with channel agonists stimulates inward calcium currents followed by emptying of cytosolic Ca2+ stores in cancer cells.
Alessandro Alaimo, Francesco Giuseppe Carbone, Kristi Buzo, Nicole Annesi, Sacha Genovesi, Annalisa Lorenzato, Karen Widmann, Michela Libergoli, Elisa Marmocchi, Giovanni Bertalot, Alberto Brolese, Mauro Giulio Papotti, Luca Molinaro, Orazio Caffo, Mattia Barbareschi, Alberto Bardelli, Alessandro Romanel, Sabrina Arena, Andrea Lunardi   +18 more
wiley   +1 more source

Evaluating the Evolving Treatment Landscape of Systemic Therapies in Penile Cancer. [PDF]

Cancers (Basel)
Jaime-Casas S, Barragan-Carrillo R, Eskenazi F, Dugarte JP, Chahoud J, Spiess PE, Medina LG.   +6 more
europepmc   +1 more source

Evaluation of a prostate SBRT planning workflow using auto‐segmentation and knowledge‐based planning

Journal of Applied Clinical Medical Physics, Volume 26, Issue 10, October 2025.
Abstract Purpose This study investigates a prostate stereotactic body radiotherapy (SBRT) planning workflow integrating commercial artificial intelligence (AI) contouring and knowledge‐based planning (KBP). The purpose is to determine whether AI‐generated contours are comparable to physician‐delineated contours in achieving dosimetric goals. Methods In
Trisha Jones, Kirk Luca, Mingdong Fan, Pretesh R. Patel, Ashesh B. Jani, Xiaofeng Yang, Justin Roper, Jie Ding   +7 more
wiley   +1 more source

Implementation of a virtual multi-disciplinary model of care for people affected by cancer: a qualitative evaluation. [PDF]

BMC Health Serv Res
Beks H, Binder MJ, Clayden S, Ludowyk J, Campbell D, Freeman J, Collins IM, Underhill C, Buzza M, Barrett M, Faisal W, Swiatek D, Ugalde A.   +12 more
europepmc   +1 more source

Inhibition of Glutamine Metabolism Attenuates Tumor Progression Through Remodeling of the Macrophage Immune Microenvironment

Advanced Biology, Volume 9, Issue 10, October 2025.
The prodrug strategy used in this study offers new promise for cancer metabolism‐based therapies. JHU083, a prodrug that, when cleaved by protease in the tumor microenvironment, yields the glutamine antagonist DON. JHU083 inhibits tumor growth by targeting glutamine‐addicted cancer cells and suppressing glutamine‐dependent M2 macrophages, leading to a ...
Tianhe Li, Sepehr Akhtarkhavari, Sumeng Qi, Jiawei Fan, Tu‐Yung Chang, Yao‐An Shen, JinMing Yang, Barbara S. Slusher, Ie‐Ming Shih, Stephanie Gaillard, Tian‐Li Wang   +10 more
wiley   +1 more source

Rolling Ultrasharp Microneedle Spheres Enable Topical Delivery of Biologics Through the Skin

Advanced Healthcare Materials, Volume 14, Issue 27, October 20, 2025.
Rolling ultraminiaturized microneedle spheres (RUMS), created via two‐photon polymerization, unlock effective and painless topical delivery of messenger RNA (mRNA) and drugs through the skin. By gently forming thousands of microscopic pores, RUMS boost skin permeability by up to 100‐fold.
Theocharis Nikiforos Iordanidis, Argyris Spyrou, Samantha Roudi, Fredrik J. Swartling, Göran Stemme, Samir EL Andaloussi, Niclas Roxhed   +6 more
wiley   +1 more source

PCPAm - A dataset of histopathological images of penile cancer for classification tasks. [PDF]

Data Brief
Mendes Lauande MG, Júnior GB, Sousa de Almeida JD, Vandecia Rejane Monteiro Fernandes, de Paiva AC, da Costa RMG, Teles AM, da Silva LL, Brito HO, Branco Vidal FC.   +9 more
europepmc   +1 more source