Results 1 to 10 of about 17,252 (224)

Pentamidine Is Not a Permeant but a Nanomolar Inhibitor of the Trypanosoma brucei Aquaglyceroporin-2. [PDF]

PLoS Pathogens, 2016
The chemotherapeutic arsenal against human African trypanosomiasis, sleeping sickness, is limited and can cause severe, often fatal, side effects. One of the classic and most widely used drugs is pentamidine, an aromatic diamidine compound introduced in ...
Jie Song, Nicola Baker, Monja Rothert, Björn Henke, Laura Jeacock, David Horn, Eric Beitz   +6 more
doaj   +13 more sources

Risk Factors for Breakthrough Pneumocystis carinii Pneumonia on Aerosol Pentamidine Prophylaxis [PDF]

Canadian Respiratory Journal, 1995
OBJECTIVE: To identify baseline characteristics of human immunodeficiency virus (HIV)-infected individuals on aerosol pentamidine for Pneumocystis carinii prophylaxis that are predictive of subsequent breakthrough Pneumocystis carinii pneumonia (PCP).
RA McIvor, AR Rachlis, P Berger, LR Lee Pack, Charles K Chan   +4 more
doaj   +2 more sources

Repurposing pentamidine for cancer immunotherapy by targeting the PD1/PD-L1 immune checkpoint [PDF]

Frontiers in Immunology, 2023
Immunotherapy has emerged as an effective therapeutic approach to several cancer types. The reinvigoration of tumor-infiltrating lymphocyte-mediated immune responses via the blockade of immune checkpoint markers, such as program cell death-1 (PD-1) or ...
Tingxuan Gu, Tingxuan Gu, Xueli Tian, Xueli Tian, Yuanyuan Wang, Yuanyuan Wang, Wenqian Yang, Wenqian Yang, Wenwen Li, Mengqiu Song, Mengqiu Song, Ran Zhao, Ran Zhao, Mengqiao Wang, Mengqiao Wang, Quanli Gao, Tiepeng Li, Chengjuan Zhang, Joydeb Kumar Kundu, Kangdong Liu, Kangdong Liu, Kangdong Liu, Zigang Dong, Zigang Dong, Mee-Hyun Lee, Mee-Hyun Lee, Mee-Hyun Lee, Mee-Hyun Lee   +27 more
doaj   +2 more sources

Pentamidine Inhibits Ovarian Cancer Cell Proliferation and Migration by Maintaining Stability of PTEN in vitro

Drug Design, Development and Therapy, 2021
Yi Wu,1 Zhong Zhang,2 Zuqiang Kou3 1Department of Pathogenic Biology, Shenyang Medical College, Shenyang City, Liaoning Province, 110004, People’s Republic of China; 2Department of Pathology, Shenyang Medical College, Shenyang City, Liaoning Province ...
Wu Y, Zhang Z, Kou Z
doaj   +3 more sources

Pentamidine dosage: a base/salt confusion. [PDF]

PLoS Neglected Tropical Diseases, 2008
Pentamidine has a long history in the treatment of human African trypanosomiasis (HAT) and leishmaniasis. Early guidelines on the dosage of pentamidine were based on the base-moiety of the two different formulations available.
Thomas P C Dorlo, Piet A Kager
doaj   +3 more sources

Co-delivery of amphotericin B and pentamidine loaded niosomal gel for the treatment of Cutaneous leishmaniasis

Drug Delivery, 2023
Topical drug delivery is preferable route over systemic delivery in case of Cutaneous leishmaniasis (CL). Among the available agents, amphotericin B (AmB) and pentamidine (PTM) showed promising result against CL.
Adnan Anjum, Kanwal Shabbir, Fakhar Ud Din, Shumaila Shafique, Syed Saoud Zaidi, Ali H Almari, Taha Alqahtani, Aleena Maryiam, Muhammad Moneeb Khan, Adel Al Fatease, Sidra Bashir, Gul Majid Khan   +11 more
doaj   +2 more sources

Insights from aquaporin structures into drug-resistant sleeping sickness [PDF]

eLife
Trypanosoma brucei is the causal agent of African trypanosomiasis in humans and animals, the latter resulting in significant negative economic impacts in afflicted areas of the world.
Modestas Matusevicius, Robin A Corey, Marcos Gragera, Keitaro Yamashita, Teresa Sprenger, Marzuq Ungogo, James N Blaza, Pablo Castro-Hartmann, Dimitri Y Chirgadze, Sundeep Chaitanya Vedithi, Pavel Afanasyev, Roberto Melero, Rangana Warshamanage, Anastasiia Gusach, José-Maria Carazo, Mark Carrington, Tom Blundell, Garib N Murshudov, Phillip J Stansfeld, Mark SP Sansom, Harry P De Koning, Christopher G Tate, Simone Weyand   +22 more
doaj   +3 more sources

Comparison between the Outcomes of Pentamidine and Trimethoprim-Sulfamethoxazole for Pneumocystis Pneumonia in Non-HIV Patients: A Nationwide Japanese Retrospective Cohort Study. [PDF]

Intern Med
Taniguchi J, Aso S, Matsui H, Fushimi K, Yasunaga H.   +4 more
europepmc   +3 more sources

Drug reformulation for a neglected disease. The NANOHAT project to develop a safer more effective sleeping sickness drug.

PLoS Neglected Tropical Diseases, 2021
BackgroundHuman African trypanosomiasis (HAT or sleeping sickness) is caused by the parasite Trypanosoma brucei sspp. The disease has two stages, a haemolymphatic stage after the bite of an infected tsetse fly, followed by a central nervous system stage ...
Lisa Sanderson, Marcelo da Silva, Gayathri N Sekhar, Rachel C Brown, Hollie Burrell-Saward, Mehmet Fidanboylu, Bo Liu, Lea Ann Dailey, Cécile A Dreiss, Chris Lorenz, Mark Christie, Shanta J Persaud, Vanessa Yardley, Simon L Croft, Margarita Valero, Sarah A Thomas   +15 more
doaj   +1 more source

Combination Therapy with Ciprofloxacin and Pentamidine against Multidrug-Resistant Pseudomonas aeruginosa: Assessment of In Vitro and In Vivo Efficacy and the Role of Resistance–Nodulation–Division (RND) Efflux Pumps

Antibiotics, 2023
The aim of this work was to (i) evaluate the efficacy of a combination treatment of pentamidine with ciprofloxacin against Galleria mellonella larvae infected with an MDR strain of P.
Megan Fletcher, Alex McCormack, Benjamin J. Parcell, Peter J. Coote   +3 more
doaj   +1 more source