In vitro Activity of Pentamidine Alone and in Combination With Aminoglycosides, Tigecycline, Rifampicin, and Doripenem Against Clinical Strains of Carbapenemase-Producing and/or Colistin-Resistant Enterobacteriaceae [PDF]
Frontiers in Cellular and Infection Microbiology, 2018 Enterobacteriaceae cause different types of community- and hospital-acquired infections. Moreover, the spread of multidrug-resistant Enterobacteriaceae is a public health problem and the World Health Organization pointed them among the pathogens in which
Tania Cebrero-Cangueiro +13 more
doaj +3 more sources
Chitosan Glutamate-Coated Niosomes: A Proposal for Nose-to-Brain Delivery [PDF]
Pharmaceutics, 2018 The aim of this in vitro study is to prepare and characterize drug free and pentamidine loaded chitosan glutamate coated niosomes for intranasal drug delivery to reach the brain through intranasal delivery.
Federica Rinaldi +9 more
doaj +5 more sources
Pentamidine Is Not a Permeant but a Nanomolar Inhibitor of the Trypanosoma brucei Aquaglyceroporin-2. [PDF]
PLoS Pathogens, 2016 The chemotherapeutic arsenal against human African trypanosomiasis, sleeping sickness, is limited and can cause severe, often fatal, side effects. One of the classic and most widely used drugs is pentamidine, an aromatic diamidine compound introduced in ...
Jie Song +6 more
doaj +6 more sources
Pentamidine-loaded gelatin decreases adhesion formation of flexor tendon [PDF]
Journal of Orthopaedic TranslationBackground: Prevention of adhesion formation following flexor tendon repair is essential for restoration of normal finger function. Although many medications have been studied in the experimental setting to prevent adhesions, clinical application is ...
Guidong Shi +10 more
doaj +2 more sources
Structural insights into drug transport by an aquaglyceroporin [PDF]
Nature CommunicationsPentamidine and melarsoprol are primary drugs used to treat the lethal human sleeping sickness caused by the parasite Trypanosoma brucei. Cross-resistance to these two drugs has recently been linked to aquaglyceroporin 2 of the trypanosome (TbAQP2 ...
Wanbiao Chen +10 more
doaj +2 more sources
Lactobacilli decrease the susceptibility of Salmonella Typhimurium to azithromycin [PDF]
Microbiology SpectrumBacteria are involved in numerous interactions during infection and among host-associated microbial populations. Salmonella enterica serovar Typhimurium is a foodborne pathogen of great importance as well as a model organism to study interactions within ...
Lya Blais +3 more
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PLoS Neglected Tropical Diseases, 2021 BackgroundHuman African trypanosomiasis (HAT or sleeping sickness) is caused by the parasite Trypanosoma brucei sspp. The disease has two stages, a haemolymphatic stage after the bite of an infected tsetse fly, followed by a central nervous system stage ...
Lisa Sanderson +15 more
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Efficacy, safety, and dose of Pafuramidine, a new oral drug for treatment of first stage sleeping sickness, in a phase 2a clinical study and phase 2b randomized clinical studies [PDF]
, 2016 Sleeping sickness (human African trypanosomiasis [HAT]) is caused by protozoan parasites and characterized by a chronic progressive course, which may last up to several years before death.
Allen, James L. +19 more
core +21 more sources
Pentamidine dosage: a base/salt confusion. [PDF]
PLoS Neglected Tropical Diseases, 2008 Pentamidine has a long history in the treatment of human African trypanosomiasis (HAT) and leishmaniasis. Early guidelines on the dosage of pentamidine were based on the base-moiety of the two different formulations available.
Thomas P C Dorlo, Piet A Kager
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Antibiotics, 2023 The aim of this work was to (i) evaluate the efficacy of a combination treatment of pentamidine with ciprofloxacin against Galleria mellonella larvae infected with an MDR strain of P.
Megan Fletcher +3 more
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