In vitro Activity of Pentamidine Alone and in Combination With Aminoglycosides, Tigecycline, Rifampicin, and Doripenem Against Clinical Strains of Carbapenemase-Producing and/or Colistin-Resistant Enterobacteriaceae [PDF]
Frontiers in Cellular and Infection Microbiology, 2018 Enterobacteriaceae cause different types of community- and hospital-acquired infections. Moreover, the spread of multidrug-resistant Enterobacteriaceae is a public health problem and the World Health Organization pointed them among the pathogens in which
Tania Cebrero-Cangueiro +13 more
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Pentamidine Is Not a Permeant but a Nanomolar Inhibitor of the Trypanosoma brucei Aquaglyceroporin-2. [PDF]
PLoS Pathogens, 2016 The chemotherapeutic arsenal against human African trypanosomiasis, sleeping sickness, is limited and can cause severe, often fatal, side effects. One of the classic and most widely used drugs is pentamidine, an aromatic diamidine compound introduced in ...
Jie Song +6 more
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Risk Factors for Breakthrough Pneumocystis carinii Pneumonia on Aerosol Pentamidine Prophylaxis [PDF]
Canadian Respiratory Journal, 1995 OBJECTIVE: To identify baseline characteristics of human immunodeficiency virus (HIV)-infected individuals on aerosol pentamidine for Pneumocystis carinii prophylaxis that are predictive of subsequent breakthrough Pneumocystis carinii pneumonia (PCP).
RA McIvor +4 more
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Drug Design, Development and Therapy, 2021 Yi Wu,1 Zhong Zhang,2 Zuqiang Kou3 1Department of Pathogenic Biology, Shenyang Medical College, Shenyang City, Liaoning Province, 110004, People’s Republic of China; 2Department of Pathology, Shenyang Medical College, Shenyang City, Liaoning Province ...
Wu Y, Zhang Z, Kou Z
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In vivo antileishmanial action of Ir-(COD)-pentamidine tetraphenylborate on Leishmania donovani and Leishmania major mouse models [PDF]
Parasite, 2000 lr-(COD)-pentamidine tetraphenylborate which has previously been studied on promastigote forms of Leishmania, was investigated for its antileishmanial properties compared with pentamidine used as reference compound.
Loiseau P.M. +4 more
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Drug Delivery, 2023 Topical drug delivery is preferable route over systemic delivery in case of Cutaneous leishmaniasis (CL). Among the available agents, amphotericin B (AmB) and pentamidine (PTM) showed promising result against CL.
Adnan Anjum +11 more
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Insights from aquaporin structures into drug-resistant sleeping sickness [PDF]
eLifeTrypanosoma brucei is the causal agent of African trypanosomiasis in humans and animals, the latter resulting in significant negative economic impacts in afflicted areas of the world.
Modestas Matusevicius +22 more
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Journal of Pharmacological Sciences, 2009 .: Although acute treatment of pentamidine does not directly modify any ionic channel function in the heart at clinically relevant concentrations, its continuous exposure can prolong QT interval.
Hirofumi Yokoyama +6 more
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Comparison between the Outcomes of Pentamidine and Trimethoprim-Sulfamethoxazole for Pneumocystis Pneumonia in Non-HIV Patients: A Nationwide Japanese Retrospective Cohort Study. [PDF]
Intern MedTaniguchi J +4 more
europepmc +3 more sources
Trypanosoma brucei aquaglyceroporin 2 is a high-affinity transporter for pentamidine and melaminophenyl arsenic drugs and the main genetic determinant of resistance to these drugs [PDF]
, 2013 OBJECTIVES: Trypanosoma brucei drug transporters include the TbAT1/P2 aminopurine transporter and the high-affinity pentamidine transporter (HAPT1), but the genetic identity of HAPT1 is unknown. We recently reported that loss of T.
Jane C. Munday +19 more
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