Results 11 to 20 of about 14,249 (201)
Risk Factors for Pneumocystis jirovecii Pneumonia in Rheumatoid Arthritis: The Protective Potential of Salazosulfapyridine. [PDF]
Int J Rheum DisABSTRACT Objectives The aim of this study was to identify the risk factors for Pneumocystis jirovecii pneumonia (PCP) in patients with rheumatoid arthritis (RA) and to recommend appropriate disease‐modifying antirheumatic drug (DMARD) selection for those at high risk of developing PCP. Methods We conducted a retrospective review of patients with RA who
Hara Y +7 more
europepmc +2 more sources
BMC Women's Health, 2022 Background Pentamidine has been reported to have many pharmacological effects including anti- protozoal, anti-inflammatory, and anti-tumor activities.
Lin Lin +4 more
doaj +1 more source
Pharmaceutics, 2023 The second-line antileishmanial compound pentamidine is administered intramuscularly or, preferably, by intravenous infusion, with its use limited by severe adverse effects, including diabetes, severe hypoglycemia, myocarditis and renal toxicity.
Lucía Román-Álamo +15 more
doaj +1 more source
S100P Interacts with p53 while Pentamidine Inhibits This Interaction
Biomolecules, 2021 S100P, a small calcium-binding protein, associates with the p53 protein with micromolar affinity. It has been hypothesized that the oncogenic function of S100P may involve binding-induced inactivation of p53. We used 1H-15N HSQC experiments and molecular
Revansiddha H. Katte +3 more
doaj +1 more source
Frontiers in Pharmacology, 2022 Toll-like receptor 4 (TLR4) is a pattern-recognition receptor (PRR) that can recognize lipopolysaccharides (LPS) and initiate the immune response, to protect the body from infection.
Siru Wu +13 more
doaj +1 more source
Repurposing pentamidine for cancer immunotherapy by targeting the PD1/PD-L1 immune checkpoint
Frontiers in Immunology, 2023 Immunotherapy has emerged as an effective therapeutic approach to several cancer types. The reinvigoration of tumor-infiltrating lymphocyte-mediated immune responses via the blockade of immune checkpoint markers, such as program cell death-1 (PD-1) or ...
Tingxuan Gu +27 more
doaj +1 more source
S100B inhibitor pentamidine attenuates reactive gliosis and reduces neuronal loss in a mouse model of Alzheimer's disease [PDF]
, 2015 Among the different signaling molecules released during reactive gliosis occurring in Alzheimer’s disease (AD), the astrocytederived S100B protein plays a key role in neuroinflammation, one of the hallmarks of the disease.
Capoccia, Elena +6 more
core +5 more sources
Trypanosoma brucei aquaglyceroporin 2 is a high-affinity transporter for pentamidine and melaminophenyl arsenic drugs and the main genetic determinant of resistance to these drugs. [PDF]
, 2013 OBJECTIVES: Trypanosoma brucei drug transporters include the TbAT1/P2 aminopurine transporter and the high-affinity pentamidine transporter (HAPT1), but the genetic identity of HAPT1 is unknown. We recently reported that loss of T.
Aguinaga Andrés, David +19 more
core +3 more sources
Artificial Cells, Nanomedicine, and Biotechnology, 2019 Nanoparticles (NPs) have gained importance in addressing drug delivery challenges across biological barriers. Here, we reformulated pentamidine, a drug used to treat Human African Trypanosomiasis (HAT) in polymer based nanoparticles and liposomes and ...
Geofrey Omarch +7 more
doaj +1 more source
Microbiology Spectrum, 2023 The increasing prevalence of carbapenem-resistant Enterobacteriaceae (CRE) and their biofilm-relevant infections pose a threat to public health. The drug combination strategy provides a new treatment option for CRE infections.
Miran Tang +8 more
doaj +1 more source