In vitro Activity of Pentamidine Alone and in Combination With Aminoglycosides, Tigecycline, Rifampicin, and Doripenem Against Clinical Strains of Carbapenemase-Producing and/or Colistin-Resistant Enterobacteriaceae [PDF]
Frontiers in Cellular and Infection Microbiology, 2018 Enterobacteriaceae cause different types of community- and hospital-acquired infections. Moreover, the spread of multidrug-resistant Enterobacteriaceae is a public health problem and the World Health Organization pointed them among the pathogens in which
Tania Cebrero-Cangueiro +13 more
doaj +3 more sources
S100B Inhibitor Pentamidine Attenuates Reactive Gliosis and Reduces Neuronal Loss in a Mouse Model of Alzheimer’s Disease [PDF]
, 2015 Among the different signaling molecules released during reactive gliosis occurring in Alzheimer’s disease (AD), the astrocytederived S100B protein plays a key role in neuroinflammation, one of the hallmarks of the disease.
Carla Cirillo +6 more
openalex +8 more sources
Chronic pentamidine aerosol prophylaxis does not induce QT-prolongation and vetricular arrythmias [PDF]
, 1993 C Thalhammer +2 more
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Fungal Biodiversity From the Atlantic Forest With Bioactive Metabolites Against Cutaneous Leishmaniasis. [PDF]
Chem BiodiversABSTRACT Biodiversity offers a rich source of bioactive compounds for drug discovery. We isolated Aspergillus fumigatus from compost in the Atlantic Forest and found its extract active against Leishmania (Leishmania) amazonensis. Two crude extracts, I06 and I75, were selected for further study.
Calado JCP +11 more
europepmc +2 more sources
Pharmaceutics, 2023 The second-line antileishmanial compound pentamidine is administered intramuscularly or, preferably, by intravenous infusion, with its use limited by severe adverse effects, including diabetes, severe hypoglycemia, myocarditis and renal toxicity.
Lucía Román-Álamo +15 more
doaj +1 more source
Efficacy, safety, and dose of Pafuramidine, a new oral drug for treatment of first stage sleeping sickness, in a phase 2a clinical study and phase 2b randomized clinical studies [PDF]
, 2016 Sleeping sickness (human African trypanosomiasis [HAT]) is caused by protozoan parasites and characterized by a chronic progressive course, which may last up to several years before death.
Allen, James L. +19 more
core +21 more sources
BMC Women's Health, 2022 Background Pentamidine has been reported to have many pharmacological effects including anti- protozoal, anti-inflammatory, and anti-tumor activities.
Lin Lin +4 more
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S100P Interacts with p53 while Pentamidine Inhibits This Interaction
Biomolecules, 2021 S100P, a small calcium-binding protein, associates with the p53 protein with micromolar affinity. It has been hypothesized that the oncogenic function of S100P may involve binding-induced inactivation of p53. We used 1H-15N HSQC experiments and molecular
Revansiddha H. Katte +3 more
doaj +1 more source
Enteric glial S100B controls rhythmic colonic functions by regulating excitability and specificity in gut motor neurocircuits. [PDF]
J PhysiolAbstract figure legend During colonic motor complex activity, enteric glia play a pivotal role by releasing the S100 calcium‐binding protein B (S100B). This gliotransmitter has both intra‐ and extracellular functions, including the regulation of neuronal and glial excitability within the enteric nervous system.
Thomasi B +5 more
europepmc +2 more sources
Frontiers in Pharmacology, 2022 Toll-like receptor 4 (TLR4) is a pattern-recognition receptor (PRR) that can recognize lipopolysaccharides (LPS) and initiate the immune response, to protect the body from infection.
Siru Wu +13 more
doaj +1 more source