Results 21 to 30 of about 17,307 (223)

Drug reformulation for a neglected disease. The NANOHAT project to develop a safer more effective sleeping sickness drug.

PLoS Neglected Tropical Diseases, 2021
BackgroundHuman African trypanosomiasis (HAT or sleeping sickness) is caused by the parasite Trypanosoma brucei sspp. The disease has two stages, a haemolymphatic stage after the bite of an infected tsetse fly, followed by a central nervous system stage ...
Lisa Sanderson, Marcelo da Silva, Gayathri N Sekhar, Rachel C Brown, Hollie Burrell-Saward, Mehmet Fidanboylu, Bo Liu, Lea Ann Dailey, Cécile A Dreiss, Chris Lorenz, Mark Christie, Shanta J Persaud, Vanessa Yardley, Simon L Croft, Margarita Valero, Sarah A Thomas   +15 more
doaj   +1 more source

Fungal Biodiversity From the Atlantic Forest With Bioactive Metabolites Against Cutaneous Leishmaniasis. [PDF]

Chem Biodivers
ABSTRACT Biodiversity offers a rich source of bioactive compounds for drug discovery. We isolated Aspergillus fumigatus from compost in the Atlantic Forest and found its extract active against Leishmania (Leishmania) amazonensis. Two crude extracts, I06 and I75, were selected for further study.
Calado JCP, Navarro MV, Alencar Chaves AF, Casula I, Ramos PL, da Cruz JB, Rodrigues AM, Lira KDL, Fonseca FLA, Xander P, de Vasconcellos SP, Batista WL.   +11 more
europepmc   +2 more sources

Pentamidine dosage: a base/salt confusion. [PDF]

PLoS Neglected Tropical Diseases, 2008
Pentamidine has a long history in the treatment of human African trypanosomiasis (HAT) and leishmaniasis. Early guidelines on the dosage of pentamidine were based on the base-moiety of the two different formulations available.
Thomas P C Dorlo, Piet A Kager
doaj   +1 more source

Combination Therapy with Ciprofloxacin and Pentamidine against Multidrug-Resistant Pseudomonas aeruginosa: Assessment of In Vitro and In Vivo Efficacy and the Role of Resistance–Nodulation–Division (RND) Efflux Pumps

Antibiotics, 2023
The aim of this work was to (i) evaluate the efficacy of a combination treatment of pentamidine with ciprofloxacin against Galleria mellonella larvae infected with an MDR strain of P.
Megan Fletcher, Alex McCormack, Benjamin J. Parcell, Peter J. Coote   +3 more
doaj   +1 more source

Pentamidine inhibits proliferation, migration and invasion in endometrial cancer via the PI3K/AKT signaling pathway

BMC Women's Health, 2022
Background Pentamidine has been reported to have many pharmacological effects including anti- protozoal, anti-inflammatory, and anti-tumor activities.
Lin Lin, Yunan Gao, Xiaochen Hu, Jiabao Ouyang, Chunbo Liu   +4 more
doaj   +1 more source

In Vitro Evaluation of Aerosol Therapy with Pentamidine-Loaded Liposomes Coated with Chondroitin Sulfate or Heparin for the Treatment of Leishmaniasis

Pharmaceutics, 2023
The second-line antileishmanial compound pentamidine is administered intramuscularly or, preferably, by intravenous infusion, with its use limited by severe adverse effects, including diabetes, severe hypoglycemia, myocarditis and renal toxicity.
Lucía Román-Álamo, Mohamad Allaw, Yunuen Avalos-Padilla, Maria Letizia Manca, Maria Manconi, Federica Fulgheri, Jorge Fernández-Lajo, Luis Rivas, José Antonio Vázquez, José Esteban Peris, Xavier Roca-Geronès, Srisupaph Poonlaphdecha, Maria Magdalena Alcover, Roser Fisa, Cristina Riera, Xavier Fernàndez-Busquets   +15 more
doaj   +1 more source

Efficacy, safety, and dose of Pafuramidine, a new oral drug for treatment of first stage sleeping sickness, in a phase 2a clinical study and phase 2b randomized clinical studies [PDF]

, 2016
Sleeping sickness (human African trypanosomiasis [HAT]) is caused by protozoan parasites and characterized by a chronic progressive course, which may last up to several years before death.
Allen, James L., Bernhard, Sonja C., Bilenge, Constantin Miaka Mia, Blum, Johannes, Burri, Christian, Josenando, Théophilo, Lubaki, Jean-Pierre Fina, Lutumba, Pascal, Manuel, Francisco, Merolle, Ada, Mesu, Victor Kande Betu Ku, Mpanya, Alain, Mpoto, Alfred Mpoo, Munungu, Blaise Fungula, Olson, Carol A., Pohlig, Gabriele, Serge, Kazadi Kyanza, Thompson, Mark, Tidwell, Richard R., Yeramian, Patrick D.   +19 more
core   +21 more sources

S100P Interacts with p53 while Pentamidine Inhibits This Interaction

Biomolecules, 2021
S100P, a small calcium-binding protein, associates with the p53 protein with micromolar affinity. It has been hypothesized that the oncogenic function of S100P may involve binding-induced inactivation of p53. We used 1H-15N HSQC experiments and molecular
Revansiddha H. Katte, Deepu Dowarha, Ruey-Hwang Chou, Chin Yu   +3 more
doaj   +1 more source

Pentamidine Alleviates Inflammation and Lipopolysaccharide-Induced Sepsis by Inhibiting TLR4 Activation via Targeting MD2

Frontiers in Pharmacology, 2022
Toll-like receptor 4 (TLR4) is a pattern-recognition receptor (PRR) that can recognize lipopolysaccharides (LPS) and initiate the immune response, to protect the body from infection.
Siru Wu, Siru Wu, Cong Lin, Tianshu Zhang, Tianshu Zhang, Bo Zhang, Bo Zhang, Yushan Jin, Hongshuang Wang, Hongyuan Li, Yibo Wang, Xiaohui Wang, Xiaohui Wang, Xiaohui Wang   +13 more
doaj   +1 more source

Enteric glial S100B controls rhythmic colonic functions by regulating excitability and specificity in gut motor neurocircuits. [PDF]

J Physiol
Abstract figure legend During colonic motor complex activity, enteric glia play a pivotal role by releasing the S100 calcium‐binding protein B (S100B). This gliotransmitter has both intra‐ and extracellular functions, including the regulation of neuronal and glial excitability within the enteric nervous system.
Thomasi B, Lavalle R, McClain JL, Jamka J, Seguella L, Gulbransen BD.   +5 more
europepmc   +2 more sources