Results 21 to 30 of about 14,249 (201)

Risk Factors for Breakthrough Pneumocystis carinii Pneumonia on Aerosol Pentamidine Prophylaxis

Canadian Respiratory Journal, 1995
OBJECTIVE: To identify baseline characteristics of human immunodeficiency virus (HIV)-infected individuals on aerosol pentamidine for Pneumocystis carinii prophylaxis that are predictive of subsequent breakthrough Pneumocystis carinii pneumonia (PCP).
RA McIvor, AR Rachlis, P Berger, LR Lee Pack, Charles K Chan   +4 more
doaj   +1 more source

The antiprotozoal drug pentamidine ameliorates experimentally induced acute colitis in mice

Journal of Neuroinflammation, 2012
Background Intestinal inflammation is partly driven by enteroglial-derived S100B protein. The antiprotozoal drug pentamidine directly blocks S100B activity.
Esposito Giuseppe, Capoccia Elena, Sarnelli Giovanni, Scuderi Caterina, Cirillo Carla, Cuomo Rosario, Steardo Luca   +6 more
doaj   +1 more source

Transport proteins determine drug sensitivity and resistance in a protozoan parasite, Trypanosoma brucei [PDF]

, 2015
Drug resistance in pathogenic protozoa is very often caused by changes to the ‘transportome’ of the parasites. In Trypanosoma brucei, several transporters have been implicated in uptake of the main classes of drugs, diamidines and melaminophenyl ...
De Koning, Harry P., Munday, Jane C., Settimo, Luca   +2 more
core   +1 more source

Positively selected modifications in the pore of TbAQP2 allow pentamidine to enter Trypanosoma brucei

eLife, 2020
Mutations in the Trypanosoma brucei aquaporin AQP2 are associated with resistance to pentamidine and melarsoprol. We show that TbAQP2 but not TbAQP3 was positively selected for increased pore size from a common ancestor aquaporin.
Ali H Alghamdi, Jane C Munday, Gustavo Daniel Campagnaro, Dominik Gurvic, Fredrik Svensson, Chinyere E Okpara, Arvind Kumar, Juan Quintana, Maria Esther Martin Abril, Patrik Milić, Laura Watson, Daniel Paape, Luca Settimo, Anna Dimitriou, Joanna Wielinska, Graeme Smart, Laura F Anderson, Christopher M Woodley, Siu Pui Ying Kelly, Hasan MS Ibrahim, Fabian Hulpia, Mohammed I Al-Salabi, Anthonius A Eze, Teresa Sprenger, Ibrahim A Teka, Simon Gudin, Simone Weyand, Mark Field, Christophe Dardonville, Richard R Tidwell, Mark Carrington, Paul O'Neill, David W Boykin, Ulrich Zachariae, Harry P De Koning   +34 more
doaj   +1 more source

Functional expression of TcoAT1 reveals it to be a P1-type nucleoside transporter with no capacity for diminazene uptake [PDF]

, 2013
It has long been established that the Trypanosoma brucei TbAT1/P2 aminopurine transporter is involved in the uptake of diamidine and arsenical drugs including pentamidine, diminazene aceturate and melarsoprol.
Al-Salabi, Barrett, Biebinger, Bray, Bridges, Burchmore, Burkard, Carter, Carter, Carter, Chitanga, Collar, Damper, De Koning, De Koning, De Koning, De Koning, De Koning, De Koning, De Koning, Delespaux, Delespaux, Delespaux, Delespaux, Eisler, Fulton, Geerts, Girgis-Takla, Gould, Hawking, Henriques, Hirumi, Lourie, Mamoudou, Matovu, Matovu, Moti, Mäser, Natto, Räz, Sanchez, Sanchez, Sanchez, Spoerri, Tamura, Teka, Wallace, Witola   +47 more
core   +1 more source

In Vitro Activity of Pentamidine Alone and in Combination with Antibiotics against Multidrug-Resistant Clinical Pseudomonas aeruginosa Strains

Antibiotics, 2020
Multidrug-resistant (MDR) Pseudomonas aeruginosa is a public health problem causing both community and hospital-acquired infections, and thus the development of new therapies for these infections is critical. The objective of this study was to analyze in
Soraya Herrera-Espejo, Tania Cebrero-Cangueiro, Gema Labrador-Herrera, Jerónimo Pachón, María Eugenia Pachón-Ibáñez, Rocío Álvarez-Marín   +5 more
doaj   +1 more source

Antistaphylococcal activity of pentamidine [PDF]

Antimicrobial Agents and Chemotherapy, 1990
Pentamidine isethionate was bacteriostatic against Staphylococcus aureus, Staphylococcus epidermidis, Streptococcus pyogenes, Streptococcus sanguis, Micrococcus sp., and Candida albicans. S. aureus was inhibited by concentrations of 16 to 64 micrograms/ml and killed by 64 to greater than or equal to 128 micrograms/ml.
G K Richards, Michael Libman, Mark A. Miller   +2 more
openaire   +3 more sources

Repurposing non-antifungal drugs auranofin and pentamidine in combination as fungistatic antifungal agents against C. albicans

Frontiers in Cellular and Infection Microbiology, 2022
Fungal infection is a serious global health issue, causing approximately 1.5 million mortalities annually. However, clinically available anti-fungal drugs are limited, especially for multidrug-resistant fungal infections.
Jiaying Lin, Xueyi Xiao, Yijing Liang, Huimin Zhao, Yingxiao Yu, Peiyan Yuan, Sha Lu, Xin Ding   +7 more
doaj   +1 more source

Metabolomics guides rational development of a simplified cell culture medium for drug screening against Trypanosoma brucei [PDF]

, 2013
n vitro culture methods underpin many experimental approaches to biology and drug discovery. The modification of established cell culture methods to make them more biologically relevant or to optimize growth is traditionally a laborious task.
Alsford, Alsford, Baltz, Barrett, Berger, Berger, Bitonti, Bowling, Bradley, Breitling, Brun, Brunda Nijagal, Creek, Creek, Creek, Darren J. Creek, de Koning, Dong-Hyun Kim, Drexler, Duszenko, Duszenko, Federico Rojas, Geary, Haanstra, Hasne, Hirumi, Hirumi, Hirumi, Jacobs, Keith R. Matthews, Kuettel, Kwon, Lanteri, Lanteri, Mashego, Michael P. Barrett, Mäser, Räz, Saunders, Scalbert, Scheltema, Scheltema, Seed, Sienkiewicz, Smith, Sumner, Sykes, t'Kindt, Tautenhahn, Vincent, Wang, Ward, Wilson, Winder, Wishart, Wu, Zaboikin, Zang, Zhang   +58 more
core   +2 more sources

Organic cation transporter 1 (OCT1) is involved in pentamidine transport at the human and mouse blood-brain barrier (BBB).

PLoS ONE, 2017
Pentamidine is an effective trypanocidal drug used against stage 1 Human African Trypanosomiasis (HAT). At the blood-brain barrier (BBB), it accumulates inside the endothelial cells but has limited entry into the brain.
Gayathri N Sekhar, Ana R Georgian, Lisa Sanderson, Gema Vizcay-Barrena, Rachel C Brown, Paula Muresan, Roland A Fleck, Sarah A Thomas   +7 more
doaj   +1 more source