Results 31 to 40 of about 17,307 (223)
S100B inhibitor pentamidine attenuates reactive gliosis and reduces neuronal loss in a mouse model of Alzheimer's disease [PDF]
, 2015 Among the different signaling molecules released during reactive gliosis occurring in Alzheimer’s disease (AD), the astrocytederived S100B protein plays a key role in neuroinflammation, one of the hallmarks of the disease.
Capoccia, Elena +6 more
core +5 more sources
Current issues in the treatment of visceral leishmaniasis. [PDF]
, 2001 A 20-year (1985-2004) retrospective review of 39 patients with imported visceral leishmaniasis found that tourism to Mediterranean countries and HIV infection were associated with visceral leishmaniasis. Diagnosis was often delayed.
Bryceson, A
core +5 more sources
Repurposing pentamidine for cancer immunotherapy by targeting the PD1/PD-L1 immune checkpoint
Frontiers in Immunology, 2023 Immunotherapy has emerged as an effective therapeutic approach to several cancer types. The reinvigoration of tumor-infiltrating lymphocyte-mediated immune responses via the blockade of immune checkpoint markers, such as program cell death-1 (PD-1) or ...
Tingxuan Gu +27 more
doaj +1 more source
Artificial Cells, Nanomedicine, and Biotechnology, 2019 Nanoparticles (NPs) have gained importance in addressing drug delivery challenges across biological barriers. Here, we reformulated pentamidine, a drug used to treat Human African Trypanosomiasis (HAT) in polymer based nanoparticles and liposomes and ...
Geofrey Omarch +7 more
doaj +1 more source
Microbiology Spectrum, 2023 The increasing prevalence of carbapenem-resistant Enterobacteriaceae (CRE) and their biofilm-relevant infections pose a threat to public health. The drug combination strategy provides a new treatment option for CRE infections.
Miran Tang +8 more
doaj +1 more source
Antibiotics, 2020 Multidrug-resistant (MDR) Pseudomonas aeruginosa is a public health problem causing both community and hospital-acquired infections, and thus the development of new therapies for these infections is critical. The objective of this study was to analyze in
Soraya Herrera-Espejo +5 more
doaj +1 more source
Green fluorescent diamidines as diagnostic probes for trypanosomes [PDF]
, 2014 LED fluorescence microscopy offers potential benefits to the diagnosis of human African trypanosomiasis, as well as to other aspects of diseases management, such as detection of drug resistant strains.
Arvind Kumar +27 more
core +1 more source
Comprehensive translational assessment of human-induced pluripotent stem cell derived cardiomyocytes for evaluating drug-induced arrhythmias [PDF]
, 2016 Induced pluripotent stem cell-derived cardiomyocytes (iPSC-CM) hold promise for assessment of drug-induced arrhythmias and are being considered for use under the comprehensive in vitro proarrhythmia assay (CiPA).
Blinova, Ksenia +17 more
core +1 more source
The antiprotozoal drug pentamidine ameliorates experimentally induced acute colitis in mice
Journal of Neuroinflammation, 2012 Background Intestinal inflammation is partly driven by enteroglial-derived S100B protein. The antiprotozoal drug pentamidine directly blocks S100B activity.
Esposito Giuseppe +6 more
doaj +1 more source
PLoS ONE, 2017 Pentamidine is an effective trypanocidal drug used against stage 1 Human African Trypanosomiasis (HAT). At the blood-brain barrier (BBB), it accumulates inside the endothelial cells but has limited entry into the brain.
Gayathri N Sekhar +7 more
doaj +1 more source