Results 31 to 40 of about 9,827 (167)

The S100B Inhibitor Pentamidine Ameliorates Clinical Score and Neuropathology of Relapsing—Remitting Multiple Sclerosis Mouse Model

Cells, 2020
S100B is an astrocytic protein acting either as an intracellular regulator or an extracellular signaling molecule. A direct correlation between increased amount of S100B and demyelination and inflammatory processes has been demonstrated.
Gabriele Di Sante, Susanna Amadio, Beatrice Sampaolese, Maria Elisabetta Clementi, Mariagrazia Valentini, Cinzia Volonté, Patrizia Casalbore, Francesco Ria, Fabrizio Michetti   +8 more
doaj   +1 more source

Chimerization at the AQP2–AQP3 locus is the genetic basis of melarsoprol–pentamidine cross-resistance in clinical Trypanosoma brucei gambiense isolates

International Journal for Parasitology: Drugs and Drug Resistance, 2015
Aquaglyceroporin-2 is a known determinant of melarsoprol–pentamidine cross-resistance in Trypanosoma brucei brucei laboratory strains. Recently, chimerization at the AQP2–AQP3 tandem locus was described from melarsoprol–pentamidine cross-resistant ...
Fabrice E. Graf, Nicola Baker, Jane C. Munday, Harry P. de Koning, David Horn, Pascal Mäser   +5 more
doaj   +1 more source

First report of treatment failure in a patient with cutaneous leishmaniasis infected by Leishmania (Viannia) naiffi carrying Leishmania RNA virus: a fortuitous combination?

Revista da Sociedade Brasileira de Medicina Tropical, 2019
We report the case of a 32-year-old man from Rio de Janeiro, who was infected in the Amazon region of Brazil by Leishmania (Viannia) naiffi. Generally, patients with L.
Ricardo Vieira-Gonçalves, Giselle Aparecida Fagundes-Silva, Júlia Furtado Heringer, Maria Fantinatti, Alda Maria Da-Cruz, Manoel Paes Oliveira-Neto, Jorge Augusto Oliveira Guerra, Adriano Gomes-Silva   +7 more
doaj   +1 more source

Long term outcomes and prognostics of visceral leishmaniasis in HIV infected patients with use of pentamidine as secondary prophylaxis based on CD4 level: a prospective cohort study in Ethiopia. [PDF]

PLoS Neglected Tropical Diseases, 2019
BACKGROUND:The long-term treatment outcome of visceral leishmaniasis (VL) patients with HIV co-infection is complicated by a high rate of relapse, especially when the CD4 count is low.
Ermias Diro, Tansy Edwards, Koert Ritmeijer, Helina Fikre, Charles Abongomera, Aderajew Kibret, Clélia Bardonneau, Peninah Soipei, Brian Mutinda, Raymond Omollo, Johan van Griensven, Eduard E Zijlstra, Monique Wasunna, Fabiana Alves, Jorge Alvar, Asrat Hailu, Neal Alexander, Séverine Blesson   +17 more
doaj   +1 more source

Nebulized Pentamidine-Induced Acute Renal Allograft Dysfunction

Case Reports in Transplantation, 2013
Acute kidney injury (AKI) is a recognised complication of intravenous pentamidine therapy. A direct nephrotoxic effect leading to acute tubular necrosis has been postulated.
Siddhesh Prabhavalkar, Agnes Masengu, Declan O'Rourke, Joanne Shields, Aisling Courtney   +4 more
doaj   +1 more source

Resistance to pentamidine is mediated by AdeAB, regulated by AdeRS, and influenced by growth conditions in Acinetobacter baumannii ATCC 17978. [PDF]

PLoS ONE, 2018
In recent years, effective treatment of infections caused by Acinetobacter baumannii has become challenging due to the ability of the bacterium to acquire or up-regulate antimicrobial resistance determinants. Two component signal transduction systems are
Felise G Adams, Uwe H Stroeher, Karl A Hassan, Shashikanth Marri, Melissa H Brown   +4 more
doaj   +1 more source

Pentamidine-loaded gelatin decreases adhesion formation of flexor tendon

Journal of Orthopaedic Translation
Background: Prevention of adhesion formation following flexor tendon repair is essential for restoration of normal finger function. Although many medications have been studied in the experimental setting to prevent adhesions, clinical application is ...
Guidong Shi, Nakagawa Koichi, Rou Wan, Yicun Wang, Ramona Reisdorf, Abigayle Wilson, Tony C.T. Huang, Peter C. Amadio, Alexander Meves, Chunfeng Zhao, Steven L. Moran   +10 more
doaj   +1 more source

Bisbenzamidines as Antifungal Agents. Are Both Amidine Functions Required to Observe an Anti-Pneumocystis carinii Activity?

Molecules, 2010
A library of 19 novel 4-(4-phenylpiperazine-1-yl)benzamidines has been synthesized and evaluated in vitro against Pneumocystis carinii. Among these compounds, N-ethyl- and N-hexyl-4-(4-phenylpiperazine-1-yl)benzamidines emerged as the most promising ...
Julien Laurent, Dimitri Stanicki, Tien L. Huang, Eduardo Dei-Cas, Muriel Pottier, El Mouktar Aliouat, Jean Jacques Vanden Eynde   +6 more
doaj   +1 more source

Diamidines versus Monoamidines as Anti-Pneumocystis Agents: An in Vivo Study

Pharmaceuticals, 2013
Some compounds articulated around a piperazine or an ethylenediamine linker have been evaluated in vitro to determine their activity in the presence of a 3T6 fibroblast cell line and an axenic culture of Pneumocystis carinii, respectively.
El-Moukhtar Aliouat, Eduardo Dei-Cas, Anna Martinez, Jean Jacques Vanden Eynde, Sébastien Boutry, Isabelle Mahieu, Delphine Forge, Claire Pinçon, Dimitri Stanicki, Muriel Pottier, Nausicaa Gantois   +10 more
doaj   +1 more source

Efficacy and safety of a single dose pentamidine (7mg/kg) for patients with cutaneous leishmaniasis caused by L. guyanensis: a pilot study [PDF]

Anais Brasileiros de Dermatologia, 2015
: BACKGROUND: There have been few studies on pentamidine in the Americas; and there is no consensus regarding the dose that should be applied. OBJECTIVES: To evaluate the use of pentamidine in a single dose to treat cutaneous leishmaniasis.
Ellen Priscilla Nunes Gadelha, Sinésio Talhari, Jorge Augusto de Oliveira Guerra, Leandro Ourives Neves, Carolina Talhari, Bernardo Gontijo, Roberto Moreira da Silva Junior, Anette Chrusciak Talhari   +7 more
doaj   +2 more sources