Results 41 to 50 of about 14,249 (201)

Functional and genetic evidence that nucleoside transport is highly conserved in Leishmania species: Implications for pyrimidine-based chemotherapy [PDF]

, 2017
Leishmania pyrimidine salvage is replete with opportunities for therapeutic intervention with enzyme inhibitors or antimetabolites. Their uptake into cells depends upon specific transporters; therefore it is essential to establish whether various ...
Ali, Juma A.M., Alzahrani, Khalid J.H., Barrett, Michael P., Creek, Darren J., De Koning, Harry P., Eze, Anthonius A., Looi, Wan Limm, Tagoe, Daniel N.A.   +7 more
core   +2 more sources

Time‐Dependent Effect of Prophylactic Trimethoprim‐Sulfamethoxazole on the Incidence of Serious Infections in Antineutrophil Cytoplasmic Antibody–Associated Vasculitis: A Target Trial Emulation Study

Arthritis &Rheumatology, EarlyView.
Objective The objective of this study was to investigate the effect of prophylactic trimethoprim‐sulfamethoxazole (TMP‐SMX) on the incidence of serious infections in patients with antineutrophil cytoplasmic antibody–associated vasculitis (AAV). Methods This multicenter cohort study was designed to emulate a target trial that studied 296 patients with ...
Yun Kyu Kim, Jeffrey R. Curtis, Se Rim Choi, Jina Yeo, Min Jung Kim, Yun Jong Lee, Eun Bong Lee, Jun Won Park   +7 more
wiley   +1 more source

Pentamidine Inhibits Ovarian Cancer Cell Proliferation and Migration by Maintaining Stability of PTEN in vitro

Drug Design, Development and Therapy, 2021
Yi Wu,1 Zhong Zhang,2 Zuqiang Kou3 1Department of Pathogenic Biology, Shenyang Medical College, Shenyang City, Liaoning Province, 110004, People’s Republic of China; 2Department of Pathology, Shenyang Medical College, Shenyang City, Liaoning Province ...
Wu Y, Zhang Z, Kou Z
doaj  

The S100B Inhibitor Pentamidine Ameliorates Clinical Score and Neuropathology of Relapsing—Remitting Multiple Sclerosis Mouse Model

Cells, 2020
S100B is an astrocytic protein acting either as an intracellular regulator or an extracellular signaling molecule. A direct correlation between increased amount of S100B and demyelination and inflammatory processes has been demonstrated.
Gabriele Di Sante, Susanna Amadio, Beatrice Sampaolese, Maria Elisabetta Clementi, Mariagrazia Valentini, Cinzia Volonté, Patrizia Casalbore, Francesco Ria, Fabrizio Michetti   +8 more
doaj   +1 more source

The Anti-Cancer Activity of Pentamidine and Its Derivatives (WLC-4059) Is through Blocking the Interaction between S100A1 and RAGE V Domain

Biomolecules, 2022
The S100A1 protein in humans is a calcium-binding protein. Upon Ca2+ binding to S100A1 EF-hand motifs, the conformation of S100A1 changes and promotes interactions with target proteins.
Nuzhat Parveen, Wei-Jung Chiu, Li-Ching Shen, Ruey-Hwang Chou, Chung-Ming Sun, Chin Yu   +5 more
doaj   +1 more source

Green Propolis Extract‐Mediated Synthesis of Biogenic Silver Nanoparticles: In Vitro Antileishmanial and Antibacterial Activities, Cytotoxicity and Ex Vivo Irritation Testing

Chemistry &Biodiversity, EarlyView.
ABSTRACT This study describes the green synthesis, characterization, and biological evaluation of silver nanoparticles (AgNPs) obtained from green propolis (AgNPs‐PRO). Before nanoparticles synthesis, a hydroethanolic green propolis extract (GPE) was obtained through ultrasound‐assisted extraction and characterized by high‐performance liquid ...
Erica Tirzah S. Lima, Victoria L. S. Santos, Wanessa J. S. Mota, Frederico S. Martins, Ricardo L. C. de Albuquerque‐Junior, André L. S. Santos, Simone S. C. Oliveira, Jéssica A. de Lima, Adriana de Jesus Santos, Cochiran P. dos Santos, Sona Jain, Eliana B. Souto, Juliana C. Cardoso, Patrícia Severino   +13 more
wiley   +1 more source

Identification of PPFIA3 as a Potential Prognostic and Immune Biomarker Through Pan‐Cancer Analysis

Organ Medicine, EarlyView.
This study reveals a significant increase in the expression of PPFIA3 across various cancers, which is associated with poor prognosis. Notably, in patients receiving anti‐PD‐L1 treatment, high PPFIA3 expression is closely linked to improved survival rates and favorable prognosis, suggesting its potential as a predictive factor for immune checkpoint ...
Xianghong Wang, Rong Lin, Chuanchuan Sun, Niujian Wu, Hongyun Lu   +4 more
wiley   +1 more source

Resistance to pentamidine is mediated by AdeAB, regulated by AdeRS, and influenced by growth conditions in Acinetobacter baumannii ATCC 17978. [PDF]

PLoS ONE, 2018
In recent years, effective treatment of infections caused by Acinetobacter baumannii has become challenging due to the ability of the bacterium to acquire or up-regulate antimicrobial resistance determinants. Two component signal transduction systems are
Felise G Adams, Uwe H Stroeher, Karl A Hassan, Shashikanth Marri, Melissa H Brown   +4 more
doaj   +1 more source

Dauricine Overcomes Osimertinib Resistance in Lung Cancer by Inducing Ferroptosis via Stabilizing SAT1

Cancer Science, EarlyView.
Our study explores the potential of dauricine, a bioactive compound from Menispermum dauricum, to overcome osimertinib resistance in lung cancer. We demonstrate that dauricine, when combined with osimertinib, induces ferroptosis in resistant lung cancer cells by stabilizing SAT1, a key enzyme in oxidative stress regulation.
Biying Men, Zhijie Chen, Haotian Ge, Zhuoying Yang, Liang Yun, Jianjun Jiang, Meijuan Dian, Yujing He, Zehao Zhou, Ruihao Zhang, Tianbao Yan, Zichao Li, Yingxin Zhang, Yongjie He, Junming He, Xuguang Rao, Shuan Rao   +16 more
wiley   +1 more source

Drug‐Event Pairs as Indicators for the Detection of Adverse Drug Reactions during Hospitalization in Routinely Collected Electronic Data Sources

Clinical Pharmacology &Therapeutics, Volume 117, Issue 6, Page 1811-1819, June 2025.
Adverse drug reactions (ADRs) are a common cause of morbidity and mortality in hospitalized patients. Identification of ADRs in clinical practice, surveillance and research is essential to prevent further harm. The aim of this study was to assess the likelihood of drugs contributing to clinically important inpatient adverse events, in order to provide ...
Anna Maria Wermund, Annette Haerdtlein, Wolfgang Fehrmann, Clara Weglage, Tobias Dreischulte, Ulrich Jaehde   +5 more
wiley   +1 more source