Results 71 to 80 of about 17,252 (224)
Arthritis &Rheumatology, Volume 77, Issue 10, Page 1407-1415, October 2025.Objective The objective of this study was to investigate the effect of prophylactic trimethoprim‐sulfamethoxazole (TMP‐SMX) on the incidence of serious infections in patients with antineutrophil cytoplasmic antibody–associated vasculitis (AAV). Methods This multicenter cohort study was designed to emulate a target trial that studied 296 patients with ...
Yun Kyu Kim +7 more
wiley +1 more source
Diamidines versus Monoamidines as Anti-Pneumocystis Agents: An in Vivo Study
Pharmaceuticals, 2013 Some compounds articulated around a piperazine or an ethylenediamine linker have been evaluated in vitro to determine their activity in the presence of a 3T6 fibroblast cell line and an axenic culture of Pneumocystis carinii, respectively.
El-Moukhtar Aliouat +10 more
doaj +1 more source
Instability of aquaglyceroporin (AQP) 2 contributes to drug resistance in Trypanosoma brucei.
PLoS Neglected Tropical Diseases, 2020 Defining mode of action is vital for both developing new drugs and predicting potential resistance mechanisms. Sensitivity of African trypanosomes to pentamidine and melarsoprol is predominantly mediated by aquaglyceroporin 2 (TbAQP2), a channel ...
Juan F Quintana +5 more
doaj +1 more source
EHA–EU MCL network guidelines for diagnosis and treatment of mantle cell lymphoma
HemaSphere, Volume 9, Issue 10, October 2025.Abstract Mantle cell lymphoma (MCL) is a relatively rare B‐cell lymphoma subtype, with a higher incidence among males and a median age of 70 years at diagnosis. MCL is characterized by clinically diverse behavior, from indolent disease to extremely aggressive, related to the presence of biological risk factors such as proliferation rate and TP53 ...
Mats Jerkeman +16 more
wiley +1 more source
Pediatric Blood &Cancer, Volume 72, Issue 10, October 2025.ABSTRACT Clostridioides difficile infection (CDI) represents a significant health risk to pediatric stem cell transplant (SCT) patients. In these patients, recurrent CDI is common, requiring prolonged antibiotic usage and increased hospitalization. Bezlotoxumab, a monoclonal antibody that targets the toxin responsible for CDI, has demonstrated efficacy
Aaron E. Fan +8 more
wiley +1 more source
His+ reversions Caused in Salmonella typhimurium by different types of ionizing radiation [PDF]
, 1988 The yield of his+ reversions in the Ames Salmonella tester strain TA2638 has been determined for 60Co γ rays, 140 kV X rays, 5.4 keV characteristic X rays, 2.2 MeV protons, 3.1 MeV α particles, and 18 MeV/U Fe ions.
Fitzek, M. +3 more
core +1 more source
Supplementary Figure 4 from Computational Repositioning and Preclinical Validation of Pentamidine for Renal Cell Cancer [PDF]
, 2023 Luiz F. Zerbini +6 more
openalex +1 more source
Kynurenine pathway inhibition reduces central nervous system inflammation in a model of human African trypanosomiasis [PDF]
, 2009 Human African trypanosomiasis, or sleeping sickness, is caused by the protozoan parasites <i>Trypanosoma brucei rhodesiense</i> or <i>Trypanosoma brucei gambiense</i>, and is a major cause of systemic and neurological disability ...
Adams +37 more
core +2 more sources
Recent Insights in Multi‐Target Drugs in Pharmacology and Medicinal Chemistry
ChemMedChem, Volume 20, Issue 18, September 25, 2025.This review highlights the rationale behind multitarget drug design as a promising approach to address diseases with complex etiologies. By combining pharmacophore features from different single‐target drugs, multitarget compounds can interact with multiple biological targets simultaneously.
Sadık Hüseyin Cemali +7 more
wiley +1 more source
Adaptation and therapeutic exploitation of the plasma membrane of African trypanosomes [PDF]
, 2018 African trypanosomes are highly divergent from their metazoan hosts, and as part of adaptation to a parasitic life style have developed a unique endomembrane system.
Canavate Del Pino, Ricardo +4 more
core +3 more sources