Results 71 to 80 of about 17,307 (223)

Trypanosoma brucei aquaglyceroporin 2 is a high-affinity transporter for pentamidine and melaminophenyl arsenic drugs and the main genetic determinant of resistance to these drugs [PDF]

, 2017
Objectives Trypanosoma brucei drug transporters include the TbAT1/P2 aminopurine transporter and the high-affinity pentamidine transporter (HAPT1), but the genetic identity of HAPT1 is unknown. We recently reported that loss of T. brucei aquaglyceroporin
Aguinaga Andrés, David, Baker, Nicola, Barrett, Michael P., Burchmore, Richard J. S., Clucas, Caroline, De Koning, Harry P., Eze, Anthonius A., Glover, Lucy, Graf, Fabrice E., Horn, David, Lee, Rebecca S., Ludin, Philipp, MacLeod, Annette, McDonald, Jennifer, Munday, Jane C., Mäser, Pascal, Natto, Manal J., Tait, Andy, Teka, Ibrahim A., Turner, C. Michael R.   +19 more
core  

A Forgotten Foe Returns: The Diagnostic Odyssey of Kala‐Azar Masquerading as Myelodysplastic Syndrome in a Post‐Elimination Era

Clinical Case Reports, Volume 13, Issue 11, November 2025.
ABSTRACT We report a diagnostically complex case of visceral leishmaniasis (Kala‐azar) in a 73‐year‐old male from a country where the disease was eliminated in 2023. The patient presented with a 2‐month history of low‐grade fever, fatigue, progressive skin hyperpigmentation over 2 years, and hepatosplenomegaly.
Sumaya Khan Mifty, Saiful Islam Chowdhury, Tahmidur Rahman, Tanveer Al Razi Khan, Swagota Roy, Faiza Ahmmed, Md. Sabbir Hossain, Ibrahim Khalil   +7 more
wiley   +1 more source

Instability of aquaglyceroporin (AQP) 2 contributes to drug resistance in Trypanosoma brucei.

PLoS Neglected Tropical Diseases, 2020
Defining mode of action is vital for both developing new drugs and predicting potential resistance mechanisms. Sensitivity of African trypanosomes to pentamidine and melarsoprol is predominantly mediated by aquaglyceroporin 2 (TbAQP2), a channel ...
Juan F Quintana, Juan Bueren-Calabuig, Fabio Zuccotto, Harry P de Koning, David Horn, Mark C Field   +5 more
doaj   +1 more source

Time‐Dependent Effect of Prophylactic Trimethoprim‐Sulfamethoxazole on the Incidence of Serious Infections in Antineutrophil Cytoplasmic Antibody–Associated Vasculitis: A Target Trial Emulation Study

Arthritis &Rheumatology, Volume 77, Issue 10, Page 1407-1415, October 2025.
Objective The objective of this study was to investigate the effect of prophylactic trimethoprim‐sulfamethoxazole (TMP‐SMX) on the incidence of serious infections in patients with antineutrophil cytoplasmic antibody–associated vasculitis (AAV). Methods This multicenter cohort study was designed to emulate a target trial that studied 296 patients with ...
Yun Kyu Kim, Jeffrey R. Curtis, Se Rim Choi, Jina Yeo, Min Jung Kim, Yun Jong Lee, Eun Bong Lee, Jun Won Park   +7 more
wiley   +1 more source

EHA–EU MCL network guidelines for diagnosis and treatment of mantle cell lymphoma

HemaSphere, Volume 9, Issue 10, October 2025.
Abstract Mantle cell lymphoma (MCL) is a relatively rare B‐cell lymphoma subtype, with a higher incidence among males and a median age of 70 years at diagnosis. MCL is characterized by clinically diverse behavior, from indolent disease to extremely aggressive, related to the presence of biological risk factors such as proliferation rate and TP53 ...
Mats Jerkeman, Igor Aurer, Elias Campo, Chan Y. Cheah, Jonathan Clark, Jeanette Doorduijn, Toby A. Eyre, Martin Fehr, Eva Giné, Maria Gomes da Silva, Pavel Klener, Marco Ladetto, Vincent Ribrag, Ofer Shpilberg, Jan Walewski, Martin Dreyling, the EHA Guidelines Committee and the European MCL Network   +16 more
wiley   +1 more source

Inducible high-efficiency CRISPR-Cas9-targeted gene editing and precision base editing in African trypanosomes [PDF]

, 2018
The Cas9 endonuclease can be programmed by guide RNA to introduce sequence-specific breaks in genomic DNA. Thus, Cas9-based approaches present a range of novel options for genome manipulation and precision editing. African trypanosomes are parasites that
A Paix, B Raz, BAA Romagnoli, CE Boothroyd, CE Clayton, D Horn, D Peng, DL Jones, E Wirtz, EL Ivanov, FE Graf, FE Graf, IM Vincent, J Song, JG Doench, JH Hu, JS Chen, L Glover, L Glover, L Glover, L Glover, L Sollelis, LC Soares Medeiros, LF Lye, M Berriman, M Jinek, M Meissner, MA Marchetti, MC Field, N Baker, N Lander, N Lander, PA Marin, PD Hsu, R Barrangou, S Alsford, S Alsford, S Dean, SM Duncan, SM Sidik, T Beneke, WW Zhang, WW Zhang, X Ren, Y Fu, Y Fu, Y Gao   +46 more
core   +2 more sources

Bezlotoxumab as Treatment for Recurrent/Chronic Clostridioides difficile Infection in Pediatric Stem Cell Transplant Recipients: A Multi‐Institutional Experience

Pediatric Blood &Cancer, Volume 72, Issue 10, October 2025.
ABSTRACT Clostridioides difficile infection (CDI) represents a significant health risk to pediatric stem cell transplant (SCT) patients. In these patients, recurrent CDI is common, requiring prolonged antibiotic usage and increased hospitalization. Bezlotoxumab, a monoclonal antibody that targets the toxin responsible for CDI, has demonstrated efficacy
Aaron E. Fan, Shaikha Alqahtani, Natalie Dailey Garnes, Priti Tewari, Demetrios Petropoulos, Sajad Khazal, Kris Mahadeo, Paige DePriest, Irtiza N. Sheikh   +8 more
wiley   +1 more source

Functional and genetic evidence that nucleoside transport is highly conserved in Leishmania species: Implications for pyrimidine-based chemotherapy [PDF]

, 2017
Leishmania pyrimidine salvage is replete with opportunities for therapeutic intervention with enzyme inhibitors or antimetabolites. Their uptake into cells depends upon specific transporters; therefore it is essential to establish whether various ...
Ali, Juma A.M., Alzahrani, Khalid J.H., Barrett, Michael P., Creek, Darren J., De Koning, Harry P., Eze, Anthonius A., Looi, Wan Limm, Tagoe, Daniel N.A.   +7 more
core   +2 more sources

Kynurenine pathway inhibition reduces central nervous system inflammation in a model of human African trypanosomiasis [PDF]

, 2009
Human African trypanosomiasis, or sleeping sickness, is caused by the protozoan parasites <i>Trypanosoma brucei rhodesiense</i> or <i>Trypanosoma brucei gambiense</i>, and is a major cause of systemic and neurological disability ...
Adams, B. Bradley, Clark, Eastman, Eastman, Giles, Gonzalez, Guidetti, Hirumi, J. Rodgers, Jennings, Jennings, Jhamandas, Kamleh, Kennedy, Kennedy, Kennedy, Kennedy, M. P. Barrett, Moffett, Okuda, Okuda, P. G. E. Kennedy, Pepin, Perkins, Pfefferkorn, P  pin, R  z, Sanni, Schroten, Schwarcz, Smith, Sternberg, Stone, Stone, Stone, T. W. Stone, Vincendeau   +37 more
core   +2 more sources

Recent Insights in Multi‐Target Drugs in Pharmacology and Medicinal Chemistry

ChemMedChem, Volume 20, Issue 18, September 25, 2025.
This review highlights the rationale behind multitarget drug design as a promising approach to address diseases with complex etiologies. By combining pharmacophore features from different single‐target drugs, multitarget compounds can interact with multiple biological targets simultaneously.
Sadık Hüseyin Cemali, Samet Poyraz, Samet Belveren, Senanur Taş, Mehmet Ali Tamer, Naciye Yaktubay Döndaş, H. Ali Döndaş, Jose Miguel Sansano   +7 more
wiley   +1 more source