Results 81 to 90 of about 17,307 (223)

Adaptation and therapeutic exploitation of the plasma membrane of African trypanosomes [PDF]

, 2018
African trypanosomes are highly divergent from their metazoan hosts, and as part of adaptation to a parasitic life style have developed a unique endomembrane system.
Canavate Del Pino, Ricardo, Field, Mark, Quintana , Juan F., Yamada, Kayo, Zhang, Ning   +4 more
core   +3 more sources

Safety and Effectiveness of Combination Rituximab and Cyclophosphamide Therapy for Treating Pediatric Patients With Severe Manifestations of Rheumatic Disease

ACR Open Rheumatology, Volume 7, Issue 9, September 2025.
Objective Current practice guidelines recommend the use of either rituximab (RTX) or cyclophosphamide (CYC) for the treatment of severe manifestations of systemic vasculitis or connective tissue disease. Few studies have evaluated safety and efficacy outcomes of combination therapy with RTX and CYC.
Eileen Rife, Daniel Reiff, John Bridges, Randall Q. Cron, Emily Smitherman, Matthew L. Stoll, Livie Timmerman, Peter Weiser, Melissa L. Mannion   +8 more
wiley   +1 more source

Efficacy and Safety of Pafuramidine versus Pentamidine Maleate for Treatment of First Stage Sleeping Sickness in a Randomized, Comparator-Controlled, International Phase 3 Clinical Trial.

PLoS Neglected Tropical Diseases, 2016
BackgroundSleeping sickness (human African trypanosomiasis [HAT]) is a neglected tropical disease with limited treatment options that currently require parenteral administration. In previous studies, orally administered pafuramidine was well tolerated in
Gabriele Pohlig, Sonja C Bernhard, Johannes Blum, Christian Burri, Alain Mpanya, Jean-Pierre Fina Lubaki, Alfred Mpoo Mpoto, Blaise Fungula Munungu, Patrick Mangoni N'tombe, Gratias Kambau Manesa Deo, Pierre Nsele Mutantu, Florent Mbo Kuikumbi, Alain Fukinsia Mintwo, Augustin Kayeye Munungi, Amadeu Dala, Stephen Macharia, Constantin Miaka Mia Bilenge, Victor Kande Betu Ku Mesu, Jose Ramon Franco, Ndinga Dieyi Dituvanga, Richard R Tidwell, Carol A Olson   +21 more
doaj   +1 more source

Aryl Phosphoramidates of 5-Phospho Erythronohydroxamic Acid, A New Class of Potent Trypanocidal Compounds [PDF]

, 2010
RNAi and enzymatic studies have shown the importance of 6-phosphogluconate dehydrogenase (6-PGDH) in Trypanosoma brucei for the parasite survival and make it an attractive drug target for the development of new treatments against human African ...
Alibu, Vincent P., Barrett, Michael P., Gilbert, Ian H., Norval, Suzanne, Read, Kevin D., Ruda, Gian Filippo, Wong, Pui Ee   +6 more
core   +4 more sources

Brain-eating amoebae: Predilection sites in the brain and disease outcome [PDF]

, 2017
Acanthamoeba spp. and Balamuthia mandrillaris are causative agents of granulomatous amoebic encephalitis (GAE), while Naegleria fowleri causes primary amoebic meningoencephalitis (PAM).
Khan, Naveed Ahmed *, Ong, Timothy Yu Yee *, Siddiqui, Ruqaiyyah Bano *   +2 more
core   +1 more source

Specific Cell Targeting Therapy Bypasses Drug Resistance Mechanisms in African Trypanosomiasis.

PLoS Pathogens, 2015
African trypanosomiasis is a deadly neglected disease caused by the extracellular parasite Trypanosoma brucei. Current therapies are characterized by high drug toxicity and increasing drug resistance mainly associated with loss-of-function mutations in ...
Juan D Unciti-Broceta, José L Arias, José Maceira, Miguel Soriano, Matilde Ortiz-González, José Hernández-Quero, Manuel Muñóz-Torres, Harry P de Koning, Stefan Magez, José A Garcia-Salcedo   +9 more
doaj   +1 more source

Site- and sequence-selective ultrafast hydration of DNA [PDF]

, 2003
Water molecules in the DNA grooves are critical for maintaining structural integrity, conformational changes, and molecular recognition. Here we report studies of site- and sequence-specific hydration dynamics, using 2-aminopurine (Ap) as the intrinsic ...
Pal, Samir Kumar, Xia, Tianbing, Zewail, Ahmed H., Zhao, Liang   +3 more
core  

Strategies to Obtain Encapsulation and Controlled Release of Pentamidine in Mesoporous Silica Nanoparticles

Pharmaceutics, 2018
Pentamidine (PTM), an antiprotozoal agent used in clinics as pentamidine isethionate salt (PTM-S), recently showed high potential also for the treatment of cancer and myotonic dystrophy type I.
Enrico Peretti, Ivana Miletto, Barbara Stella, Flavio Rocco, Gloria Berlier, Silvia Arpicco   +5 more
doaj   +1 more source

Application of magnetically induced hyperthermia on the model protozoan Crithidia fasciculata as a potential therapy against parasitic infections

, 2012
Magnetic hyperthermia is currently an EU-approved clinical therapy against tumor cells that uses magnetic nanoparticles under a time varying magnetic field (TVMF).
Asín, L., Goya, G. F., Grazú, V., Ibarra, M. R., Marquina, C., Moros, M., Silber, A. M., Torres, T. E.   +7 more
core   +1 more source

Action of pentamidine-bound nanoparticles againstLeishmaniaon anin vivomodel [PDF]

, 1994
Thierry Fusaı̈, M Deniau, Rémy Durand, Christian Bories, Muriel Paul, D. Rivollet, A. Astier, R. Houin   +7 more
openalex   +1 more source