Results 81 to 90 of about 14,249 (201)

S100B‑p53 disengagement by pentamidine promotes apoptosis and inhibits cellular migration via aquaporin‑4 and metalloproteinase‑2 inhibition in C6 glioma cells

, 2015
S100 calcium‑binding protein B (S100B) is highly expressed in glioma cells and promotes cancer cell survival via inhibition of the p53 protein. In melanoma cells, this S100B‑p53 interaction is known to be inhibited by pentamidine isethionate, an ...
CAPOCCIA E, CIRILLO C, CUOMO, ROSARIO, D'ALESSANDRO, ALESSANDRA, ESPOSITO G., MARCHETTO A, PESCE, MARCELLA, SARNELLI, GIOVANNI, SAWIKR Y, SCUDERI C, STEARDO L, TIBERI S   +11 more
core   +2 more sources

Effects of Acute Intravenous Administration of Pentamidine, a Typical hERG-Trafficking Inhibitor, on the Cardiac Repolarization Process of Halothane-Anesthetized Dogs

Journal of Pharmacological Sciences, 2009
.: Although acute treatment of pentamidine does not directly modify any ionic channel function in the heart at clinically relevant concentrations, its continuous exposure can prolong QT interval.
Hirofumi Yokoyama, Yuji Nakamura, Hiroshi Iwasaki, Yukitoshi Nagayama, Kiyotaka Hoshiai, Yoshitaka Mitsumori, Atsushi Sugiyama   +6 more
doaj  

Specific Cell Targeting Therapy Bypasses Drug Resistance Mechanisms in African Trypanosomiasis.

PLoS Pathogens, 2015
African trypanosomiasis is a deadly neglected disease caused by the extracellular parasite Trypanosoma brucei. Current therapies are characterized by high drug toxicity and increasing drug resistance mainly associated with loss-of-function mutations in ...
Juan D Unciti-Broceta, José L Arias, José Maceira, Miguel Soriano, Matilde Ortiz-González, José Hernández-Quero, Manuel Muñóz-Torres, Harry P de Koning, Stefan Magez, José A Garcia-Salcedo   +9 more
doaj   +1 more source

Efficacy and Safety of Pafuramidine versus Pentamidine Maleate for Treatment of First Stage Sleeping Sickness in a Randomized, Comparator-Controlled, International Phase 3 Clinical Trial.

PLoS Neglected Tropical Diseases, 2016
BackgroundSleeping sickness (human African trypanosomiasis [HAT]) is a neglected tropical disease with limited treatment options that currently require parenteral administration. In previous studies, orally administered pafuramidine was well tolerated in
Gabriele Pohlig, Sonja C Bernhard, Johannes Blum, Christian Burri, Alain Mpanya, Jean-Pierre Fina Lubaki, Alfred Mpoo Mpoto, Blaise Fungula Munungu, Patrick Mangoni N'tombe, Gratias Kambau Manesa Deo, Pierre Nsele Mutantu, Florent Mbo Kuikumbi, Alain Fukinsia Mintwo, Augustin Kayeye Munungi, Amadeu Dala, Stephen Macharia, Constantin Miaka Mia Bilenge, Victor Kande Betu Ku Mesu, Jose Ramon Franco, Ndinga Dieyi Dituvanga, Richard R Tidwell, Carol A Olson   +21 more
doaj   +1 more source

Independence from kinetoplast DNA maintenance and expression is associated with multi-drug resistance in Trypanosoma brucei in vitro [PDF]

, 2014
It is well known that several antitrypanosomatid drugs accumulate in the parasite's mitochondrion, where they often bind to the organellar DNA, the kinetoplast.
A. Schnaufer, Agbe, Bruhn, Brun, Cristodero, Dean, Deterding, Herbert, Hoare, Holmes, Kaminsky, Lai, Lanteri, M. K. Gould, Mathis, Mukherjee, Painter, Priest, Roy Chowdhury, Räz, Schnaufer, Schnaufer, Schnaufer, Shapiro, Stuart, Tang, Thuita, Ward, Wenzler, Wenzler, Wilson, Zhang, Zuma   +32 more
core   +1 more source

Strategies to Obtain Encapsulation and Controlled Release of Pentamidine in Mesoporous Silica Nanoparticles

Pharmaceutics, 2018
Pentamidine (PTM), an antiprotozoal agent used in clinics as pentamidine isethionate salt (PTM-S), recently showed high potential also for the treatment of cancer and myotonic dystrophy type I.
Enrico Peretti, Ivana Miletto, Barbara Stella, Flavio Rocco, Gloria Berlier, Silvia Arpicco   +5 more
doaj   +1 more source

Trypanosoma brucei aquaglyceroporin 2 is a high-affinity transporter for pentamidine and melaminophenyl arsenic drugs and the main genetic determinant of resistance to these drugs [PDF]

, 2017
Objectives Trypanosoma brucei drug transporters include the TbAT1/P2 aminopurine transporter and the high-affinity pentamidine transporter (HAPT1), but the genetic identity of HAPT1 is unknown. We recently reported that loss of T. brucei aquaglyceroporin
Aguinaga Andrés, David, Baker, Nicola, Barrett, Michael P., Burchmore, Richard J. S., Clucas, Caroline, De Koning, Harry P., Eze, Anthonius A., Glover, Lucy, Graf, Fabrice E., Horn, David, Lee, Rebecca S., Ludin, Philipp, MacLeod, Annette, McDonald, Jennifer, Munday, Jane C., Mäser, Pascal, Natto, Manal J., Tait, Andy, Teka, Ibrahim A., Turner, C. Michael R.   +19 more
core  

Exploiting the Achilles' heel of membrane trafficking in trypanosomes [PDF]

, 2016
Pathogenic protozoa are evolutionarily highly divergent from their metazoan hosts, reflected in many aspects of their biology. One particularly important parasite taxon is the trypanosomatids.
Adl, Adung’a, Ali, Alsford, Alsford, Alsford, Baker, Baker, Bassarak, Berriman, Bridges, David Horn, Doherty, Field, Gadelha, Gadelha, Graf, Graf, Harry P de Koning, Jackson, Jackson, Lacomble, Lecordier, Leung, Leung, Manna, Manna, Manna, Manna, Mark C Field, Martin Zoltner, Matovu, Matovu, Moeller, Morgan, Munday, Munday, Munday, Mäser, Opoku-Temeng, Pal, Peck, Peña, Salvador, Sangaré, Shimogawa, Silverman, Song, Steverding, Stijlemans, Teka, Tomavo, Travis, Unciti-Broceta, Vansterkenburg, Wu, Zoltner   +56 more
core   +3 more sources

A retrospective study of intravenous pentamidine for Pneumocystis jirovecii pneumonia prophylaxis in adult patients with hematologic malignancies—its utility during respiratory virus pandemics

International Journal of Infectious Diseases
Objectives: In hematology, prophylaxis for Pneumocystis jirovecii pneumonia (PCP) is recommended for patients undergoing hematopoietic stem cell transplantation and in selected categories of intensive chemotherapy for hematologic malignancies ...
Yi Xin Liew, Aloysius Yew Leng Ho, Gee Chuan Wong, Shimin Jasmine Chung, Thuan Tong Tan, Ban Hock Tan   +5 more
doaj  

Dihydropteroate synthase gene mutations in Pneumocystis and sulfa resistance [PDF]

, 2004
Pneumocystis pneumonia (PCP) remains a major cause of illness and death in HIV-infected persons. Sulfa drugs, trimethoprim-sulfamethoxazole (TMP-SMX) and dapsone are mainstays of PCP treatment and prophylaxis.
Atzori, C, Benfield, T, Crothers, KA, Haung, L, Helweg-Larsen, J, Miller, R, Rabodonirina, M   +6 more
core   +2 more sources