Results 41 to 50 of about 9,188,053 (283)

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

PANoptosis in the pathogenesis of myelodysplastic syndromes

Molecular Oncology, EarlyView.
PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla, Jyoti Lamichhane, Cameron Lewis, Peter Breslin, Jiwang Zhang   +4 more
wiley   +1 more source

Development of integrated care pathways: toward a care management system to meet the needs of frail and disabled community-dwelling older people

International Journal of Integrated Care, 2013
Introduction: The home care and services provided to older adults with the same needs are often inadequate and highly varied. Integrated care pathways (ICPs) can resolve these issues.
Nicole Dubuc, Lucie Bonin, André Tourigny, Luc Mathieu, Yves Couturier, Michel Tousignant, Cinthia Corbin, Nathalie Delli-Colli, Michel Raîche   +8 more
doaj   +3 more sources

Provider perceptions of barriers and facilitators to care in eating disorder treatment for transgender and gender diverse patients: a qualitative study

Journal of Eating Disorders, 2023
Plain English summary Eating disorders are more common among transgender and non-binary compared to cisgender people. Despite this, gender diverse people who seek eating disorder treatment often report struggling to find affirming and inclusive care.
Katarina A. Ferrucci, Emily McPhillips, Kate L. Lapane, Bill M. Jesdale, Catherine E. Dubé   +4 more
doaj   +1 more source

New Frontiers of People-Centered Integrated Care for Complex Chronic Disease

Journal of Palliative Care & Medicine, 2015
Objective: Heart failure is a chronic, progressive clinical syndrome with an unpredictable trajectory and difficult prognosis. In 2012, the Italian region of Friuli-Venezia Giulia was appointed pilot leader of a European-funded project for ICT-supported integrated care addressed to European frail citizens, to test the viability and evaluate the impact ...
Stellato K Radini D, Pellizzari M Pordenon M   +1 more
openaire   +1 more source

Pathways and pitfalls: a qualitative study of student experiences in biomedical science education

FEBS Open Bio, EarlyView.
Biomedical science students from underrepresented backgrounds face barriers including financial strain, disrupted laboratory access and cultural exclusion. Peer networks provide vital support when institutional systems are difficult to navigate. To create inclusive learning environments and achieve academic success, educators should blend active, hands‐
Olivia J. Russell, Cassy Ross, Panagiota S. Filippou, Bruno Silvester Lopes, Dominic Gilchrist, Paul Dean, Kamar Ameen‐Ali, Tora K. Smulders‐Srinivasan, Ahmad A. Khundakar   +8 more
wiley   +1 more source

Chronobiology of Cancer: How Aging Fuels Oncogenesis at the Molecular Level

Aging and Cancer, EarlyView.
This graphical abstract illustrates the key biological pathways linking aging with cancer development and progression. In the upper left, cumulative exposure to ultraviolet radiation, toxins, and reactive oxygen species (ROS) causes DNA damage and genomic instability, whereas age‐related decline in repair mechanisms, such as ATM/ATR, BER, and NER ...
Anu Singh, Aroonima Misra, Sufian Zaheer
wiley   +1 more source

Person-centered care for common mental disorders in Ontario’s primary care patient-centered medical homes: a qualitative study of provider perspectives

BMC Primary Care
Background For more than a decade, the Patient-Centered Medical Home model has been a guiding vision for the modernization of primary care systems. In Canada, Ontario’s Family Health Teams (FHTs) were designed in the mid-2000s with the medical home model
Matthew Menear, Rachelle Ashcroft, Simone Dahrouge, Jose Silveira, Jocelyn Booton, Monica Emode, Kwame McKenzie   +6 more
doaj   +1 more source

WELCOMING PRACTICE IN PSYCHOSOCIAL CARE FOR THE PERSON-CENTERED CARE

Cogitare Enfermagem, 2023
Objective: To analyze the practice of welcoming people into psychosocial care for person-centered care. Method: A qualitative, strategic social research study based on the Person-Centered Clinical Method, conducted with 17 professionals from two ...
Johnatan Martins Sousa, Marciana Gonçalves Farinha, Joyce Soares Silva Landim, Roselma Lucchese, Thatianny Tanferri de Brito Paranaguá, Fernanda Costa Nunes, Ana Lúcia Queiroz Bezerra   +6 more
doaj   +1 more source

A strong future for young people leaving out-of-home care [PDF]

, 2014
Young people leaving care or who have left care are over-represented in the statistics on homelessness, early school leaving and contact with the criminal justice system.
Toni Beauchamp
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