Results 91 to 100 of about 1,358,742 (313)

Spatiotemporal Sequential Delivery of Chidamide Regulates Macrophage Reprogramming in Lymphoma Microenvironment Through HDACs‐STAT3 Pathway

Advanced Science, EarlyView.
Our study identifies the HDACs‐STAT3 axis as key regulator for M2 macrophage accumulation in DLBCL. We developed Chid@M2pep‐EVs/TP, a pH‐responsive drug delivery system for M2 macrophage specific chidamide administration. By coupling M2‐targeted chidamide with EVs‐mediated delivery, this system reprograms M2 to M1 via HDAC inhibition and STAT3 ...
Bo Dai, Shuo Wang, Xiaotong Peng, Kunpeng Wu, Mengyao Wu, Zhaoning Lu, Haoshu Zhong, Xiaohan Qian, Shuiyi Tan, Hui Yang, Tanlezi Sun, Jing Wang, Jie Zhang, Hua Jiang, Yin Tong, Tong Chen   +15 more
wiley   +1 more source

Assessing understandings and perceptions of HIV cure among peer navigators and treatment officers in Australia

HIV Research & Clinical Practice
HIV community peer navigators and treatment officers are important sources of information and guidance for people living with HIV. We conducted an anonymous online survey with members of the treatment outreach network of the Australian National ...
Jillian S. Y. Lau, Brent Clifton, John Rule, Jeanne Ellard, James H. McMahon   +4 more
doaj   +1 more source

Certificate of Membershp in the Indiana Colonization Society

The American Colonization Society was founded in 1816. Its mission was to help free blacks emigrate and establish a colony in West Africa. Modeled after the national organization, the Indiana Colonization Society was organized in Indianapolis in 1829 ...
Indiana Colonization Society
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Climate Plans for the People: Civil society and community participation in national action plans on climate change

In 2024, countries will be submitting their new Nationally Determined Contributions (NDCs) as commitments towards tackling climate change. These plans impact everyone and must therefore be inclusive. Practices across eleven countries show the main actors
Christina Hill, Pruett, Duncan, Duncan Pruett, Hill, Christina   +3 more
core   +1 more source

Piezo2 Mediates a Vicious Cycle of “Mechanical Homeostasis Imbalance—Inflammation” in Sensory Nerves and the Cartilage Endplate

Advanced Science, EarlyView.
In a lumbar spine instability model, dorsal root ganglion cells mediate the perception of relevant mechanical stresses through Piezo2 and subsequently release CGRP. CGRP activates the NF‐κB signaling pathway in cartilage endplate cells through the receptor RAMP1.
Hanpeng Xu, Wen Geng, Zhi Du, Yifan Du, Di Wu, Bide Tong, Huaizhen Liang, Xingyu Zhou, Zixuan Ou, Junyu Wei, Kun Wang, Yu Song, Wenbin Hua, Yan Xu, Wencan Ke, Bingjin Wang, Cao Yang   +16 more
wiley   +1 more source

Mariah Huntley

, 2008
Helped Elder Haskell in the first Tract Society work, South Lancaster, Massachusetts. This G. I. Butler family album was donated in 1989 by two granddaughters of G.
Unknown
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Consensus Formation and Change are Enhanced by Neutrality

Advanced Science, EarlyView.
Neutral agents are shown to enhance both the formation and overturning of consensus in collective decision‐making. A general mathematical model and experiments with locusts and humans reveal that neutrality enables robust consensus via simple interactions and accelerates consensus change by reducing effective population size.
Andrei Sontag, Janina A. Hoffmann, Tim Rogers, Christian A. Yates   +3 more
wiley   +1 more source

#KnowMyViralLoad: how community-led demand creation holds a key to routine viral load testing scale-up in Africa

BMC Public Health
Background Viral load testing (VLT) is key to detecting treatment failure and is central to HIV management. However, low demand for routine VLT among people on antiretroviral treatment limits opportunities for evidence-based HIV management and ...
Helen Etya’ale, Collins Otieno Odhiambo, Bactrin Killingo, Susan Perez, Pontsho Pilane, Anafi Mataka, Idrissa Songo, Carol Ameera Kassam, Tonderai Mwareka, Evelyn Letio, Ange Mavula, Nelson Otwoma, Pascale Ondoa   +12 more
doaj   +1 more source

Invisible families: The strengths and needs of black families in which young people have caring responsibilities

, 2002
This study investigated the experiences and needs of black young people caring for disabled or ill family members and their access to services. A joint research team from Manchester Metropolitan University and the Bibini Centre for Young People ...
Jones, A, Jeyasingham, Dharman, Rajasooriya, S, Jones, Adele, Jeyasingham, Dharman; id_orcid, Rajasooriya, Sita, Jeyasingham, D   +6 more
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Chronic obstructive pulmonary disease education in pulmonary rehabilitation : an official American Thoracic Society/Thoracic Society of Australia and New Zealand/Canadian Thoracic Society/British Thoracic Society workshop report

, 2018
According to the 2013 American Thoracic Society/European Respiratory Society statement on pulmonary rehabilitation (PR), education to promote effective self-management is a cornerstone of this intervention. Despite education's stature within PR, there is
Durning, S. J., Blackstock, Felicity C. (R18424), Nici, L., Singh, S., Kelly, W., Buckley, M., Bourbeau, J., American Thoracic Society, Lareau, S. C., Thoracic Society of Australia and New Zealand, Effing, T. W., Egbert, E., Goldstein, R. S., ZuWallack, R., Lee, A., Meek, P. M., British Thoracic Society, Canadian Thoracic Society   +17 more
core   +1 more source