Advanced Science, EarlyView.Cryopreserved lung‐humanized mice overcome the dependency to fresh tissues and permit head‐to‐head profiling of all four human common cold coronaviruses versus SARS‐CoV‐2 infection; the model validates Paxlovid efficacy against HKU1 and, when coupled with human immune‐system engraftment, enables interrogation of lung‐resident human immunity and HKU1 ...
Chunyu Cheng +9 more
wiley +1 more source
Brief Report: HIV Incidence Among People Who Inject Drugs, San Francisco, 2022. [PDF]
J Acquir Immune Defic SyndrElbur AI +5 more
europepmc +1 more source
Advanced Science, EarlyView.Osteosarcoma is the most common primary bone tumor with limited treatment options and a terrible prognosis. This review provides a comprehensive summary of the recent development of osteoimmunomodulatory implants for post‐operative osteosarcoma treatment, of which the potential utility in evoking durable anti‐osteosarcoma immunity and accelerating bone
Yilong Dong +6 more
wiley +1 more source
Impact of Longitudinal Patterns of Alcohol Use on Mortality in People Who Inject Drugs: A Prospective, Community-based Cohort Study. [PDF]
J Addict MedChen PH +8 more
europepmc +1 more source
Longitudinal changes in personal wellbeing in a cohort of people who inject drugs
, 2017 Nick Scott +5 more
openalex +2 more sources
Efficacy of Direct-acting Antivirals for Chronic Hepatitis C Virus Infection in People Who Inject Drugs or Receive Opioid Substitution Therapy: A Systematic Review and Meta-analysis [PDF]
, 2019 Christiana Graf +8 more
openalex +1 more source
Advanced Science, EarlyView.The loss of Ubiquitin Specific Peptidase 26 (USP26) in osteoblasts results in decreased bone formation, as well as multi‐organ fibrosis associated with insulin resistance (IR). Mechanistically, the absence of USP26 reduces glycolysis and lactate accumulation, leading to decreased histone H3 lysine 18 lactylation (H3K18LA) in the promoter region of KH ...
Jiyuan Tang +9 more
wiley +1 more source
Micro-costing analysis of a community-based psychiatric intervention among people who inject drugs in Haiphong, Vietnam. [PDF]
Front PsychiatryTrouiller P +11 more
europepmc +1 more source
Hepatitis C virus prevention and treatment prioritization—ethical, economic and evidential dimensions of early rather than delayed treatment for people who inject drugs [PDF]
, 2016 Matthew Hickman +2 more
openalex +1 more source
Advanced Science, EarlyView.Here it is revealed that the costimulatory receptors CD27 and ICOS are essential for the long‐term maintenance of PD‐1high CD8+ TRM cells following influenza infection. PD‐L1 blockade enhances the proliferation and activation of these cells through Nur77 activation downstream of the CD27/ICOS signaling axis, thereby boosting host immunity against ...
Yuanyuan Chen +16 more
wiley +1 more source