Results 241 to 250 of about 26,526,867 (295)

Loss of CYLD on Chromosome 16q Impairs Homologous Recombination and Genomic Stability Through TIRR Degradation

open access: yesAdvanced Science, EarlyView.
Chromosome 16q loss drives genomic instability through disruption of the CYLD–TIRR–53BP1 axis. CYLD preserves homologous recombination by stabilizing TIRR and limiting 53BP1 accumulation at DNA double‐strand breaks. CYLD deficiency redirects repair toward error‐prone non‐homologous end joining, promotes mutational burden and homologous recombination ...
Mingming Lu   +14 more
wiley   +1 more source

Organic Nanozyme‐Embedded Biotherapeutic Thermosensitive Hydrogel for Extracellular GSH Depletion and Postoperative Tumor Suppression

open access: yesAdvanced Science, EarlyView.
A temperature‐sensitive hydrogel loaded with cyanine nanozymes and Escherichia coli is locally injected into postoperative tumor resection beds. Upon light irradiation, synergistic PTT and PDT work with cascaded reactive oxygen species to deplete extracellular GSH, eliminate residual tumor cells, and induce robust antitumor immune responses for ...
Cong Jiang   +10 more
wiley   +1 more source

The power of people who use drugs as mass media influencers in changing public opinion during the global overdose epidemic. [PDF]

open access: yesSubst Abuse Treat Prev Policy
Jozaghi E   +1 more
europepmc   +1 more source

Transitions from first drug use to illicit opioid and injection drug use in a multisite rural U.S. cohort of people who use drugs. [PDF]

open access: yesHarm Reduct J
Fredericksen RJ   +15 more
europepmc   +1 more source

Role of the media in promoting the dehumanization of people who use drugs

The American Journal of Drug and Alcohol Abuse, 2023
Dehumanization, the perception or treatment of people as subhuman, has been recognized as "endemic" in medicine and contributes to the stigmatization of people who use illegal drugs, in particular. As a result of dehumanization, people who use drugs are subject to systematically biased policies, long-lasting stigma, and suboptimal healthcare. One major
Daniel Roy Sadek Habib   +2 more
openaire   +2 more sources

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