Results 281 to 290 of about 1,506,029 (346)

Caveolin‐1 Stabilizes SERCA2 to Counteract Acute Kidney Injury via Suppression of Ca2+‐Dependent Endoplasmic Reticulum Stress in Distal Tubules

Advanced Science, EarlyView.
In AKI, initial kidney injury upregulates the expression of Cav‐1, which subsequently binds to and stabilizes SERCA2 via its scaffolding domain and through deubiquitination, thereby regulating Ca2+ homeostasis and ER stress. Conversely, Cav‐1 deficiency accelerates SERCA2 degradation, triggering Ca2+ overload and ER stress, and ultimately exacerbating ...
Yan Zhang, Xin He, Hao Huang, Rong Lu, Xin Lv, Shenglan Li, Sijue Zou, Jiawei Cheng, Yiwei Xiong, Zhenghao Deng, Qiongjing Yuan, Yanyun Xie, Ling Huang, Jiaxi Pu, Shao Liu, Qianbin Li, Jie Meng, Huixiang Yang, Lijian Tao, Zhangzhe Peng   +19 more
wiley   +1 more source

Amputation trends among people who use drugs in the context of Philadelphia's increasingly xylazine adulterated drug supply. [PDF]

Drug Alcohol Depend
Laurano R, Pogorzelska-Maziarz M, Green TC, Beachy S, Rising KL, Hom JK, Reed MK.   +6 more
europepmc   +1 more source

A Viscous DES‐AAV‐Foxo1 Delivery System With High Transfection Efficiency for the Treatment of Corneal Endothelial Dysfunction by Restoring Mitochondria‐ER Contacts

Advanced Science, EarlyView.
High glucose triggers corneal endothelial dysfunction by impairing FOXO1‐mediated ITPR1 transcription, leading to disrupted mitochondria‐associated membrane (MAM) integrity and defective ER‐to‐mitochondria Ca2+ transfer. This study develops an innovative viscous DES‐AAV‐Foxo1 delivery system with enhanced transfection efficiency. This non‐invasive gene
Hongran Zhao, Xiaoyu Li, Hongwei Wang, Zongyi Li, Qun Wang, Yangyang Zhang, Xu Jing, Xia Qi, Qingjun Zhou, Shengqian Dou, Lixin Xie   +10 more
wiley   +1 more source

Advancing pre-exposure prophylaxis (PrEP) implementation for people who use drugs: an introduction to and lessons from the special series. [PDF]

Addict Sci Clin Pract
Bazzi AR, Tookes HE, Bartholomew TS.
europepmc   +1 more source

Assessing the knowledge, attitudes, and psychological health of people who use drugs towards Hepatitis C: a cross-sectional study. [PDF]

Front Public Health
Liu Y, Zhang X, Cao Z, Zhu S, Fu J.
europepmc   +1 more source

Harm reduction services and interventions for People Who Use Drugs (PWUD) in Latin America and the Caribbean (LAC) between 2013-2024: A scoping review protocol. [PDF]

PLoS One
Bórquez I, Bailey K, Laynor G, Toledo L, Bastos FI, Santaella-Tenorio J, Castillo-Carniglia Á, Cerdá M, Krawczyk N.   +8 more
europepmc   +1 more source

Perceived Barriers and Potential Strategies for People Who Use Drugs in Accessing Oral Healthcare: A Qualitative Study of Service Providers. [PDF]

Community Dent Oral Epidemiol
Kangutkar T, Gussy M, Knevel R, Calache H.   +3 more
europepmc   +1 more source

Sensitivity and Specificity of Natural Language Processing Systems for Identification of Hospitalized People Who Use Drugs. [PDF]

Open Forum Infect Dis
Benrubi L, Sato T, Westgard LK, Zollo-Venecek K, Socrates B, Sweigart B, Ridgway JP, Suzuki J, Morales Y, Goodman-Meza D, Wurcel AG.   +10 more
europepmc   +1 more source

Gender-based differences in harm reduction practices among people who use drugs in Rhode island: a latent class analysis. [PDF]

Harm Reduct J
Shaw LC, Kumar A, Park CJ, Li Y, Lenox CA, Collins AB, Sherman SG, Marshall BDL, Macmadu A.   +8 more
europepmc   +1 more source

'We need to help people who use drugs make healthier choices, not treat them as criminals'

, 2018
Duffin, Tony
core