Results 41 to 50 of about 43,421 (258)

TOLLIP Inhibits Psoriasis Progression via Suppressing PKM2‐Mediated Glycolysis in Keratinocytes

Advanced Science, EarlyView.
In this study, we identify TOLLIP as a critical regulator of psoriasis pathogenesis through its modulation of glycolytic metabolism. Our findings establish the TOLLIP‐PKM2‐glycolysis axis as a key mechanism linking metabolic reprogramming to psoriasis pathogenesis, and propose TOLLIP as a promising therapeutic target.
Xiuhuan Jiang, Guoying Miao, Na Shen, Qingxia Han, Xiaoru Han, Zichang Qiao, Kexin Feng, Zhuo Tan, Yaguang Wang, Xiuhua Liu, Chen Wu, Zhenzhen Yan   +11 more
wiley   +1 more source

An integrated online-to-offline model for HIV post-exposure prophylaxis (O2O-PEP) scale-up among men who have sex with men (MSM): Protocol for developing a pilot randomized controlled trial

Frontiers in Public Health, 2022
BackgroundHIV post-exposure prophylaxis (PEP) is an evidence-based biomedical HIV prevention strategy consisting of a 28-day course of highly active antiretroviral therapy after recent potential exposure to HIV. However, awareness and uptake of PEP among
Qianqian Luo, Yongchuan Luo, Tianying Li, Tianyu Cui   +3 more
doaj   +1 more source

Shade compromises the photosynthetic efficiency of NADP-ME less than that of PEP-CK and NAD-ME C4 grasses

Journal of Experimental Botany, 2018
Photosynthesis and productivity are less compromised by low light in NADP-ME C4 grasses relative to PEP-CK and NAD-ME counterparts.
B. V. Sonawane, R. Sharwood, S. Whitney, O. Ghannoum   +3 more
semanticscholar   +1 more source

De Novo Design of Membrane‐Targeting Antimicrobial Peptides Against Gram‐Negative Bacteria Using a Generative Artificial Intelligence Framework

Advanced Science, EarlyView.
Antimicrobial resistance caused by Gram‐negative bacteria remains difficult to overcome due to the protective outer membrane. To address this challenge, a multi‐condition constrained generative AI framework, GenMTAMP is proposed for de novo membrane‐targeting antimicrobial peptide design by integrating physicochemical and spatial structure descriptors.
Jingxiao Yu, Da‐Wen Sun, QingYi Wei, Yibing Zhang, Jidong Tang, Hongbin Pu   +5 more
wiley   +1 more source

Simulation of the rise in pore water pressure due to embankment load during the construction phase of the levee

Media Komunikasi Teknik Sipil, 2023
Inflow in Jatiluhur Reservoir located on the Citarum River is influenced by outflow from Cirata Reservoir and Saguling Reservoir which are above it. These three reservoirs are incorporated in the Citarum Cascade System Reservoir.
Togani Cahyadi Upomo, Dian Eka Aryanti, Rini Kusumawardani   +2 more
doaj   +1 more source

An enhanced regimen as post-exposure chemoprophylaxis for leprosy: PEP++

BMC Infectious Diseases, 2018
The ongoing transmission of Mycobacterium (M.) leprae reflected in a very slow decline in leprosy incidence, forces us to be innovative and conduct cutting-edge research.
L. Mieras, Anna T Taal, W. van Brakel, E. Cambau, Paul Saunderson, W. C. Smith, C. Prakoeswa, Linda Astari, David M. Scollard, Dejair Caitano do Nascimento, J. Grosset, H. K. Kar, S. Izumi, L. Gillini, M. Virmond, M. Sturkenboom   +15 more
semanticscholar   +1 more source

Membrane‐Active Peptide Protects Against Inflammation by Targeting NLRP3 Activation at the Trans‐Golgi Network

Advanced Science, EarlyView.
The membrane‐active peptide Pep19‐2.5 reduces harmful inflammation by blocking activation of the NLRP3 inflammasome at trans‐Golgi network membranes. By targeting key membrane interactions, Pep19‐2.5 suppresses inflammatory IL‐1β production and alleviates allergic airway inflammation in mice, leading to reduced immune cell infiltration and improved ...
Jonas Engelhardt, Nico Kirsch, Aileen Kerfin, Lars P. Lunding, Dominic Ferber, Hannes Buthmann, Ilka Schreier, Carlotta Bosio, Ann‐Kathrin Dobbelstein, Anna Klawonn, Rebecca C. Coll, Lena Bauernhofer, Sandro Keller, Matthias Geyer, Michael Wegmann, Andra B. Schromm, Günther Weindl   +16 more
wiley   +1 more source

Evaluation of Post-Exposure Prophylaxis Utilization Among Human Immunodeficiency Virus Exposed Victims at University of Gondar Comprehensive Specialized Hospital, North West Ethiopia

HIV/AIDS: Research and Palliative Care, 2020
Eyosiyas Temesgen, 1 Haile Weldu, 2 Kefyalew Ayalew Getahun, 3 Tezera Jemere Aragaw 3 1Jewish Voice Ministries International, Addis Ababa, Ethiopia; 2Shiraro Hospital, North Tigray, Ethiopia; 3Department of Pharmacology, College of Medicine and Health
Temesgen E, Weldu H, Ayalew Getahun K, Jemere Aragaw T   +3 more
doaj  

Super‐Multiplexed Label‐Free Raman Imaging Uncovers Novel Testicular Metabolic Couplings for Residual Body and Spermatogonial Differentiation

Advanced Science, EarlyView.
Super‐multiplexed Label‐free Raman Imaging (SLRI) enables 2D/3D metabolic mapping of intact Drosophila testes. Moving beyond descriptive morphology, it establishes a multidimensional tool for tissue metabolic remodeling, and offers a generalizable platform for complex tissue analysis, with implications extending to development and disease. ABSTRACT The
Jiaxin Li, Xia Chen, Yujuan Qi, Chen Qiao, Qiuru Huang, Dan Zhao, Weiyi Qian, Li Di, Yi Shi, Xiangqi Hu, Yueyue Shao, Kehan Wang, Zhiyu Tang‐Yang, Hanzhi Zang, Yuwen Du, Anran Dong, Jinxiong Feng, Jiayun Chen, Ying Zheng, Xiaofang Tan, Xiaoyu Zhao, Zhonghua Shi, Bo Zheng, Jun Yu   +23 more
wiley   +1 more source

Efecto de la invasión de acacia negra (Gleditsia triacanthos L.) sobre arroyos pampeanos

Biología Acuática, 2014
Los ecosistemas fluviales pampeanos de orden bajo suelen carecer de vegetación ribereña. En los últimos años, la invasión de la langosta de la miel (Gleditsia triacanthos L.) ha causado cambios en la composición del paisaje.
Carolina Vilches, Ana María Torremorell, Juan Debandi, M. Carolina Rodríguez Castro, Laura Rigacci, Eduardo Zunino, Sebastián Kravetz, Adonis Giorgi   +7 more
doaj