Results 11 to 20 of about 19,551 (125)

Effectiveness of islatravir post-exposure prophylaxis after intravenous challenge with simian immunodeficiency virus in rhesus macaques. [PDF]

J Int AIDS Soc
Abstract Introduction Islatravir (ISL) is a nucleoside reverse transcriptase translocation inhibitor (NRTTI) with robust antiretroviral activity. The efficacy of ISL administered for post‐exposure prophylaxis (PEP) was evaluated in a simian immunodeficiency virus (SIV) rhesus macaque intravenous (IV) challenge model. Methods Twelve rhesus macaques were
Markowitz M, Gettie A, St Bernard L, Grasperge B, Vargo R, Pham M, Fillgrove K, Dube N, Diamond TL, Hazuda DJ, Grobler JA.   +10 more
europepmc   +2 more sources

Fabrication of a Lipopolysaccharide-Targeting Peptide-Based Colloid for Alleviating Carbapenem-Resistant Enterobacteriaceae-Induced Cutaneous Infection. [PDF]

Adv Healthc Mater
In this study, a novel cationic peptide, IW is designed and synthesized, with a tandem‐repeat sequence demonstrating potent activities against a broad spectrum of clinically relevant Carbapenem‐resistant Enterobacteriaceae in both the planktonic and biofilm states. IW is then formulated with P407 to form IW‐P407 colloids.
Zeng P, Ding X, Liu C, Chen S, Chan KF, Leung SSY.   +5 more
europepmc   +2 more sources

Translocation of bacteria from animal excrements to soil and associated habitats [PDF]

, 2009
The population dynamics of Salmonella enterica var. Typhimurium MAE 110 gfp, Escherichia coli O157:H7 gfp, and Pseudomonas fluorescens 32 gfp were investigated in their introduction to cattle excrements and subsequent entering the soil, plants of cress ...
Bruggen, A.H.C., van, Kunenkova, N.N., Kupriyanov, A.A., Semenov, A.M.   +3 more
core   +2 more sources

Simvastatin overcomes the pPCK1‐pLDHA‐SPRINGlac axis‐mediated ferroptosis and chemo‐immunotherapy resistance in AKT‐hyperactivated intrahepatic cholangiocarcinoma

Cancer Communications, EarlyView.
Abstract Background Intrahepatic cholangiocarcinoma (ICC) is a challenging cancer with an increasing incidence. The Phase III TOPAZ‐1/KEYNOTE‐966 study demonstrated chemo‐immunotherapy (CIT) as a significant advancement, potentially replacing traditional chemotherapy for advanced biliary tract cancer.
Jinghan Zhu, Yixiao Xiong, Yuxin Zhang, Huifang Liang, Kun Cheng, Yuanxiang Lu, Guangzhen Cai, Yang Wu, Yunhui Fan, Xiaoping Chen, Hong Zhu, Zeyang Ding, Wanguang Zhang   +12 more
wiley   +1 more source

Peptide RL‐QN15 Regulates Functions of Epidermal Stem Cells to Accelerate Skin Wound Regeneration via the FZD8/β‐Catenin Axis

Exploration, EarlyView.
Amphibian‐derived peptide RL‐QN15 activates the Wnt/β‐catenin signaling pathway by interacting with the FZD8 membrane receptor, promoting epidermal stem cells proliferation, migration, stemness, and EMT processes, thus promoting skin wound healing.
Yuansheng Li, Qiuye Jia, Naixin Liu, Saige Yin, Junyuan Wang, Yujing Ding, Yuliu Yang, Ying Peng, Zeqiong Ru, Shaoyang Zhang, Bu'er Qi, Jun Sun, Li He, Ying Wang, Kun Guo, Xinwang Yang   +15 more
wiley   +1 more source

Protein transduction: A novel tool for tissue regeneration [PDF]

, 2002
Tissue regeneration in humans is limited and excludes vitals organs like heart and brain. Transformation experiments with oncogenes like T antigen have shown that retrodifferentiation of the respective cells is possible but hard to control. To bypass the
Derer W., Han K., Ho A., Park J., Theodore L.   +4 more
core   +1 more source

Nanoplatform‐Enabled Genetic Interventions for Central Nervous System Disorders: Advances in Delivery Strategies and Therapeutic Potential

Advanced Genetics, EarlyView.
This review provides a detailed description of gene mutations and epigenetic mechanisms in central nervous system (CNS) disease, strategies for gene therapy, challenges for CNS gene therapy and gene‐drug nanocarriers. This review also summarizes the applications of nanogenetic therapy platforms in CNS diseases (brain tumors, neurodegenerative diseases,
Fuming Liang, Shizhen Cui, Jing Yang, Zhaohui He, Ling Zhu   +4 more
wiley   +1 more source

Comparative LC‐MS Proteomics of Quinoa Grains: Evaluation of Bioactivity and Health Benefits by Combining In Silico Techniques With In Vitro Assays on Colorectal Adenocarcinoma Cells

Molecular Nutrition &Food Research, EarlyView.
Identifying health‐promoting molecules such as bioactive peptides in complex food mixtures is a major challenge. In this study, we investigated proteins and protein hydrolysates from four quinoa varieties to evaluate their potential anticancer effects on colorectal adenocarcinoma cells.
Alessandro Zaccarelli, Beatrice Mattina, Rocío Galindo‐Luján, Laura Pont, Fernando Benavente, Ilaria Zanotti, Lisa Elviri   +6 more
wiley   +1 more source

The aspartic proteinase family of three Phytophthora species [PDF]

, 2011
Background - Phytophthora species are oomycete plant pathogens with such major social and economic impact that genome sequences have been determined for Phytophthora infestans, P. sojae and P. ramorum.
Have, A., ten, Kan, J.A.L., van, Kay, J., Meijer, H.J.G.   +3 more
core   +1 more source

Clustering of Membrane Receptors: Insights from DNA Origami‐Based Approaches

Small, EarlyView.
Receptor clustering critically influences cell signaling, yet its precise regulation remains elusive. This review highlights how DNA origami structures serve as nanoscale tools to uncover receptor organization and provide new insights into signal transduction.
Carmen M. Domínguez, Christof M. Niemeyer   +1 more
wiley   +1 more source