Results 31 to 40 of about 19,551 (125)

Protein Nanopore-Based Discrimination between Selected Neutral Amino Acids from Polypeptides [PDF]

open access: yes, 2017
Nanopore probing of biological polymers has the potential to achieve single-molecule sequencing at low cost, high throughput, portability, and minimal sample preparation and apparatus. In this article, we explore the possibility of discrimination between
Asandei, Alina   +4 more
core   +1 more source

Optimization of ClpXP activity and protein synthesis in an E. coli extract-based cell-free expression system. [PDF]

open access: yes, 2018
Protein degradation is a fundamental process in all living cells and is essential to remove both damaged proteins and intact proteins that are no longer needed by the cell.
Joseph, Simpson   +4 more
core   +2 more sources

Modelling the impact of initiation delay, duration and prior PrEP on the efficacy of post‐exposure prophylaxis containing a tenofovir/emtricitabine backbone

open access: yesJournal of the International AIDS Society, Volume 28, Issue S1, June 2025.
Abstract Introduction Pre‐ and post‐exposure prophylaxis (PrEP and PEP) are important pillars of the HIV prevention portfolio to reduce the risk of acquisition just before or after HIV exposure. While PrEP efficacy has been elucidated in many randomized clinical trials, corresponding data for PEP is extremely difficult to obtain in a controlled setting.
Lanxin Zhang   +3 more
wiley   +1 more source

Lipopolysaccharide as trigger of platelet aggregation via eicosanoid over-production [PDF]

open access: yes, 2017
The effect of lipopolysaccharide (LPS) on platelet aggregation is still controversial. We performed in vitro and ex vivo studies in controls and in patients with community-acquired pneumonia (CAP) to assess the effect of LPS on platelet activation (PA ...
Camilla Calvieri   +9 more
core   +1 more source

Mitochondrial Transplantation: A Novel Therapeutic Approach for Treating Diseases

open access: yesMedComm, Volume 6, Issue 6, June 2025.
This article describes the roles of mitochondria in health and disease and reviews the effects of mitochondrial transplantation in disease, including restoring ATP production, attenuating oxidative stress, modulating inflammatory responses, reducing apoptosis, promoting cell repair, and exhibiting antitumor properties.
Xinglu Miao   +4 more
wiley   +1 more source

Effect of Ammonium:Nitrate Application Ratios on Growth and Nitrogen Metabolism of Tea Plants (Camellia sinensis L.)

open access: yesPlant Direct, Volume 9, Issue 6, June 2025.
ABSTRACT Tea plants (Camellia sinensis L.) use ammonium and nitrate as the main sources of nitrogen (N), but they respond differently to these two compounds. In this study, we investigated the effect of the ammonium:nitrate ratio on tea plant growth as well as N uptake and metabolism.
Takuo Enomoto   +7 more
wiley   +1 more source

Domain organization of long autotransporter signal sequences [PDF]

open access: yes, 2010
Bacterial autotransporters represent a diverse family of proteins that autonomously translocate across the inner membrane of Gram-negative bacteria via the Sec complex and across the outer bacterial membrane.
Hiß, Jan Alexander   +1 more
core   +1 more source

The Different Cellular Entry Routes for Drug Delivery Using Cell Penetrating Peptides

open access: yesBiology of the Cell, Volume 117, Issue 6, June 2025.
Cell‐penetrating peptides (CPPs) represent a promising, non‐invasive strategy for delivering a wide variety of molecular cargoes including proteins, nucleic acids, and small molecules into cells. Due to their versatility, CPPs have shown significant potential in areas such as drug delivery, gene therapy, cancer treatment, and vaccine development ...
Michael Okafor   +6 more
wiley   +1 more source

Cell-Penetrating Peptides, Electroporation, and Drug Delivery

open access: yes, 2010
Certain short polycations, such as TAT and oligoarginine, rapidly pass through the plasma membranes of mammalian cells by a mechanism called transduction, as well as by endocytosis and macropinocytosis.
Cahill, Kevin
core   +1 more source

Genomic investigations of successful invasions: the picture emerging from recent studies

open access: yesBiological Reviews, Volume 100, Issue 3, Page 1396-1418, June 2025.
ABSTRACT Invasion biology aims to identify traits and mechanisms that contribute to successful invasions, while also providing general insights into the mechanisms underlying population expansion and adaptation to rapid climate and habitat changes. Certain phenotypic attributes have been linked to successful invasions, and the role of genetics has been
Joanna Kołodziejczyk   +7 more
wiley   +1 more source

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