Results 31 to 40 of about 20,021 (136)

Endomicroscopic and transcriptomic analysis of impaired barrier function and malabsorption in environmental enteropathy [PDF]

, 2016
Introduction: Environmental enteropathy (EE) is associated with growth failure, micronutrient malabsorption and impaired responses to oral vaccines.
A Prendergast, A Veitch, AC Illing, AJ Prendergast, Alastair Watson, AM Marchiando, AM Marchiando, AM Marchiando, AR Tenorio, B Sandström, Beatrice Amadi, D Gunzel, DI Campbell, E Salazar-Lindo, Ellen Besa, EM Vestergaard, G Marchetti, GC Cook, GT Keusch, J Brenchley, J Vesterbacka, J Zulu, James Lees, JH Humphrey, JM Williams, John Louis-Auguste, JR Turner, Kanekwa Zyambo, L Aamann, L Bremholm, LG Lim, LS Valberg, M Kosek, MH Wojcik, MJ Manary, MM Levine, MS Wapenaar, N Kimer, P Bellot, P Janssen, P Kelly, P Kelly, P Kelly, Paul Kelly, PB Jeppesen, Q Xiao, R Kiesslich, R Kiesslich, RL Guerrant, Rose Soko, Rosemary Banda, S Baldassano, S Tarazona, T Mizuno, Themba Banda, U Trautvetter, V Giorgio, VF Zevallos, W Dhaliwal, WA Petri, William A. Petri, Y Guan   +61 more
core   +5 more sources

GSH as an A‐A Type Allosteric Activator of PKM2: Modulating Cancer Cell Homeostasis and Ferroptosis Susceptibility

Advanced Science, Volume 13, Issue 5, 27 January 2026.
Glutathione (GSH) defines oxidative balance, but can it directly tune central metabolism? The research reveals that GSH binds and potently activates pyruvate kniase M2 (PKM2), rewiring glycolysis and dictating ferroptosis sensitivity. Combining GSH depletion with PKM2 activation triggers mitochondrial damage and lipid peroxidation, profoundly ...
Tsan‐Jan Chen, Chi‐Jen Lo, Meng‐Jen Wu, Wei Yang Sit, Hsin‐Yu Hsu, Yi‐Cheng Huang, Chien‐Hung Lu, Yu‐Lun Chen, Wei‐Kai Fang, Shan‐Min Yang, Pei‐Lien Chen, Tokuko Haraguchi, Yasushi Hiraoka, Chun‐Yu Lin, Mei‐Ling Cheng, Muh‐Hwa Yang, Hsing‐Jien Kung, Wen‐Ching Wang   +17 more
wiley   +1 more source

Drug hypersensitivity caused by alteration of the MHC-presented self-peptide repertoire [PDF]

, 2012
Idiosyncratic adverse drug reactions are unpredictable, dose independent and potentially life threatening; this makes them a major factor contributing to the cost and uncertainty of drug development. Clinical data suggest that many such reactions involve
A. Lucas, A. M. English, A. Sette, A. Wriston, B. J. Grant, B. Peters, C. A. F. de Oliveira, C. Oseroff, Cahalan, Chessman, Chung, D. A. Ostrov, D. F. Hunt, Day, E. Phillips, Faletto, Friesner, H. M. Grey, H. Mei, Harndahl, J. Jakoncic, J. Shabanowitz, J. Sidney, Ko, L. Shi, L. Yang, Lavergne, M. Harndahl, Mallal, Martin, Melroy, Phillips, Pichler, Rudolph, S. Buus, S. Lu, S. Mallal, S. Southwood, Shastri, Shimizu, Sidney, Sidney, Tenzer, Udeshi, Y. A. Pompeu, Yang, Yang, Yewdell   +47 more
core   +4 more sources

Comprehensive Analysis of Malate Accumulation in Peaches in Response to Cold Stress Based on Transcriptomics

Food Science &Nutrition, Volume 14, Issue 1, January 2026.
This study explored malate‐accumulation mechanisms in “Hujingmilu” peaches under different storage conditions. Low temperature (LT) delayed firmness decline and maintained higher malate. Transcriptomics showed malate biosynthetic genes weakly correlate with malate levels, while proton pump and transporter genes were up‐regulated under LT.
Hongfang Cai, Shuai Han, Xu Wang, Jiqing Shi, Zewen Xiong, Zheng Zhang, Zhuyi Gao   +6 more
wiley   +1 more source

Domain organization of long autotransporter signal sequences [PDF]

, 2010
Bacterial autotransporters represent a diverse family of proteins that autonomously translocate across the inner membrane of Gram-negative bacteria via the Sec complex and across the outer bacterial membrane.
Hiß, Jan Alexander, Schneider, Gisbert (Prof. Dr.)   +1 more
core   +1 more source

Unravelling the Significance of Phosphoenolpyruvate Carboxylase in Phosphate Starvation Responses

Plant, Cell &Environment, Volume 49, Issue 1, Page 177-192, January 2026.
ABSTRACT Low phosphate availability is a major concern for agriculture. Plants develop a plethora of responses to improve phosphate acquisition, known as phosphate starvation responses (PSR). Among them, the induction of phosphoenolpyruvate carboxylase (PEPC) has been described in many plants. However, most studies have been conducted in the absence of
Jesús Pérez‐López, Clara de la Osa, Jacinto Gandullo, Nora Gigli‐Bisceglia, Inmaculada Coleto, Ana Belén Feria, Cristina Echevarría, Christa Testerink, Daniel Marino, Sofía García‐Mauriño, José A. Monreal   +10 more
wiley   +1 more source

Sequencing proteins with transverse ionic transport in nanochannels [PDF]

, 2015
{\it De novo} protein sequencing is essential for understanding cellular processes that govern the function of living organisms and all post-translational events and other sequence modifications that occur after a protein has been constructed from its ...
Boynton, P., Di Ventra, M.
core   +4 more sources

Nanomedicines Against Mitochondrial Dysfunction‐Induced Metabolic Diseases

Advanced Science, Volume 12, Issue 48, December 29, 2025.
Mitochondrial dysfunction is central to metabolic diseases. Nanomedicine offers transformative approaches for restoring function via targeted delivery, responsive release, and multimodal therapy. This review outlines the pathological basis, nanocarrier design, organelle‐specific targeting, recent advances, and future clinical translation challenges ...
Ke Xu, Leyi Wang, Tao Lv, Chen Jin, Qiong Wu, Yongjie Zhou, Gang Xu, Zhenyu Duan, Kui Luo, Jiayin Yang   +9 more
wiley   +1 more source

Molecular dynamics simulations and in silico peptide ligand screening of the Elk-1 ETS domain [PDF]

, 2011
Background: The Elk-1 transcription factor is a member of a group of proteins called ternary complex factors, which serve as a paradigm for gene regulation in response to extracellular signals. Its deregulation has been linked to multiple human diseases
Hirst, J.D., Hussain, A., Shaw, P.E.
core   +3 more sources

Biosynthesis and Application of Catechins and Their Derivatives in Camellia sinensis

Food Science &Nutrition, Volume 13, Issue 12, December 2025.
This review summarizes the biosynthesis, structural diversity, and functional properties of catechins in tea. It highlights their tissue‐specific accumulation in different tea tissues and discusses the potential applications of catechin derivatives in functional foods and health‐related products.
Haiyi Yao, Yuxin Gu, Dibin Zhu, Dandan Tang, Wei Chen, Yongxian Chen, Jiaojiao Zhang, Liqiang Tan   +7 more
wiley   +1 more source