Results 41 to 50 of about 234,024 (149)

SHARK‐capture identifies functional motifs in intrinsically disordered protein regions

Protein Science, Volume 34, Issue 4, April 2025.
Abstract Increasing insights into how sequence motifs in intrinsically disordered regions (IDRs) provide functions underscore the need for systematic motif detection. Contrary to structured regions where motifs can be readily identified from sequence alignments, the rapid evolution of IDRs limits the usage of alignment‐based tools in reliably detecting
Chi Fung Willis Chow, Swantje Lenz, Maxim Scheremetjew, Soumyadeep Ghosh, Doris Richter, Ceciel Jegers, Alexander von Appen, Simon Alberti, Agnes Toth‐Petroczy   +8 more
wiley   +1 more source

Energy-independent translocation of cell-penetrating peptides occurs without formation of pores. A biophysical study with pep-1

Molecular membrane biology, 2007
Pep-1 is a cell-penetrating peptide (CPP) with the ability to translocate across biological membranes and introduce active proteins inside cells. The uptake mechanism used by this CPP is, as yet, unknown in detail.
S. Troeira Henriques, A. Quintas, L. Bagatolli, F. Homblé, M. Castanho   +4 more
semanticscholar   +1 more source

Fighting Antimicrobial Resistance: Innovative Drugs in Antibacterial Research

Angewandte Chemie International Edition, Volume 64, Issue 10, March 3, 2025.
This article provides an overview over antibacterial drugs investigated in the past three decades. Aspects of the compound's origins, their cellular targets, the antibacterial spectrum and proof‐of‐concept in animal studies are covered and current trends are highlighted.
Roderich D. Süssmuth, Marcel Kulike‐Koczula, Peng Gao, Simone Kosol   +3 more
wiley   +1 more source

Purely exponential parametrizations and their group-theoretic applications [PDF]

arXiv, 2023
This paper is mainly motivated by the analysis of the so-called Bounded Generation property (BG) of linear groups (in characteristic $0$), which is known to admit far-reaching group-theoretic implications. We achieve complete answers to certain longstanding open questions about Bounded Generation (sharpening considerably some earlier results).
arxiv  

Peptide‐Bound Aflibercept Eye Drops for Treatment of Neovascular Age‐Related Macular Degeneration in Nonhuman Primates

Advanced Science, Volume 12, Issue 11, March 20, 2025.
This article demonstrates that the peptide bxyPenetratin (bxyWP) non‐covalently binds to the anti‐vascular endothelial growth factor (VEGF) protein aflibercept via hydrophobic interactions, enabling noninvasive delivery of aflibercept to the choroid and retina through conjunctival‐scleral pathway and effective inhibition of choroidal neovascularization
Xingyan Fan, Kuan Jiang, Yongqian Zhao, Benjamin TK Lee, Feiyang Geng, Marten E Brelen, Weiyue Lu, Gang Wei   +7 more
wiley   +1 more source

Cigarette smoke‐induced HMGB1 translocation and release contribute to migration and NF‐κB activation through inducing autophagy in lung macrophages

Journal of Cellular and Molecular Medicine, 2019
High‐mobility group box 1 (HMGB1) shows pro‐inflammatory activity in various inflammatory diseases and has been found up‐regulated in chronic obstructive pulmonary disease (COPD).
Yanqing Le, Yanhong Wang, Lu Zhou, J. Xiong, Jieyu Tian, Xia Yang, X. Gai, Yongchang Sun   +7 more
semanticscholar   +1 more source

Evolutionary Insight and Expression Pattern of WUSCHEL‐Related Homebox Genes of Dendrobium huoshanense

Food Science &Nutrition, Volume 13, Issue 3, March 2025.
Nine WOX genes were identified in D. huoshanense. The phylogenetic tree suggests they belong to three classical clades. All DhWOX genes are subject to purifying selection, with replication times dating back as early as 363 MYA. D. huoshanense has more gene pairs with its relative species, consistent with their genetic relationship.
Jing Wang, Yingyu Zhang, Yanshuang Ren, Muhammad Aamir Manzoor, Shanyong Yi, Cheng Song   +5 more
wiley   +1 more source

Group A Streptococcal Cysteine Protease Cleaves Epithelial Junctions and Contributes to Bacterial Translocation*

Journal of Biological Chemistry, 2013
Background: Group A Streptococcus (GAS) translocates across the host epithelial barrier. Results: Streptococcal pyrogenic exotoxin B (SpeB) directly cleaves junctional proteins.
T. Sumitomo, M. Nakata, Miharu Higashino, Y. Terao, S. Kawabata   +4 more
semanticscholar   +1 more source

Colorectal Cancer: Pathogenesis and Targeted Therapy

MedComm, Volume 6, Issue 3, March 2025.
Chromosomal instability, microsatellite instability, and the CpG island methylator phenotype are key pathogenic pathways in the adenoma–carcinoma sequence of CRC. Epigenetic remodeling and metabolic reprogramming are two major hallmarks of tumor cells, demonstrating bidirectional regulatory mechanisms across various cancers, including CRC.
Jingyuan Li, Jiashu Pan, Lisheng Wang, Guang Ji, Yanqi Dang   +4 more
wiley   +1 more source

Quantum Theory as emergent from an undulatory translocal Sub-Quantum Level [PDF]

arXiv, 2012
We argue that quantum theory is a low-energy effective theory which emerges from some sub-quantum level theory which is of an undulatory and translocal character. We show the close connection of quantum theory with both gravity and the holographic principle which are different phenomena of one and the same theory on this primordial level.
arxiv