Results 51 to 60 of about 19,430 (137)

Mitochondria and neuroprotection in stroke: Cationic arginine-rich peptides (CARPs) as a novel class of mitochondria-targeted neuroprotective therapeutics [PDF]

, 2018
Stroke is the second leading cause of death globally and represents a major cause of devastating long-term disability. Despite sustained efforts to develop clinically effective neuroprotective therapies, presently there is no clinically available ...
Anderton, Ryan S, Knuckey, Neville W, MacDougall, Gabriella, Mastaglia, Frank L, Meloni, Bruno P   +4 more
core   +1 more source

Phytochrome activates the plastid-encoded RNA polymerase for chloroplast biogenesis via nucleus-to-plastid signaling. [PDF]

, 2019
Light initiates chloroplast biogenesis by activating photosynthesis-associated genes encoded by not only the nuclear but also the plastidial genome, but how photoreceptors control plastidial gene expression remains enigmatic.
Blaha, Gregor M, Cao, Jun, Chen, Meng, Pasoreck, Elise K, Wang, He, Weigel, Detlef, Yoo, Chan Yul   +6 more
core   +2 more sources

LC-MS proteomics analysis of the iInsulin/IGF-1-deficient Caenorhabditis elegans daf-2(e1370) mutant reveals extensive restructuring of intermediary metabolism [PDF]

, 2014
The insulin/IGF-1 receptor is a major known determinant of dauer formation, stress resistance, longevity, and metabolism in Caenorhabditis elegans. In the past, whole-genome transcript profiling was used extensively to study differential gene expression ...
Braeckman, Bart, Brewer, Heather M, Camp, David G, II, Depuydt, Geert, Petyuk, Vladislav A, Smith, Richard D, Smolders, Arne, Xie, Fang   +7 more
core   +2 more sources

Drug hypersensitivity caused by alteration of the MHC-presented self-peptide repertoire [PDF]

, 2012
Idiosyncratic adverse drug reactions are unpredictable, dose independent and potentially life threatening; this makes them a major factor contributing to the cost and uncertainty of drug development. Clinical data suggest that many such reactions involve
A. Lucas, A. M. English, A. Sette, A. Wriston, B. J. Grant, B. Peters, C. A. F. de Oliveira, C. Oseroff, Cahalan, Chessman, Chung, D. A. Ostrov, D. F. Hunt, Day, E. Phillips, Faletto, Friesner, H. M. Grey, H. Mei, Harndahl, J. Jakoncic, J. Shabanowitz, J. Sidney, Ko, L. Shi, L. Yang, Lavergne, M. Harndahl, Mallal, Martin, Melroy, Phillips, Pichler, Rudolph, S. Buus, S. Lu, S. Mallal, S. Southwood, Shastri, Shimizu, Sidney, Sidney, Tenzer, Udeshi, Y. A. Pompeu, Yang, Yang, Yewdell   +47 more
core   +4 more sources

Molecular Electroporation and the Transduction of Oligoarginines

, 2009
Certain short polycations, such as TAT and polyarginine, rapidly pass through the plasma membranes of mammalian cells by an unknown mechanism called transduction as well as by endocytosis and macropinocytosis.
Alberts B, Alberts B, Alberts B, Alberts B, Alberts B, Bevers E, Bulte J W, Cahill K, Datta K, Grandmaison P A, Hanke M, Harbour J W, Hosotani R, Kevin Cahill, Kuge O, Mai J C, Mendoza N, Vaara M, Vance J E, Voelker D, Vondrášek J   +20 more
core   +1 more source

Changes in the microsomal proteome of tomato fruit during ripening [PDF]

, 2019
The variations in the membrane proteome of tomato fruit pericarp during ripening have been investigated by mass spectrometry-based label-free proteomics.
De Lorenzo, Giulia, Fabbri, Claudia, Licursi, Valerio, Mattei, Benedetta, Negri, Rodolfo, Pontiggia, Daniela, Spinelli, Francesco   +6 more
core   +1 more source

Efficient processing of an antigenic sequence for presentation by MHC class I molecules depends on its neighboring residues in the protein [PDF]

, 1991
Processing of endogenously synthesized proteins generates short peptides that are presented by MHC class I molecules to CD8 T lymphocytes. Here it is documented that not only the sequence of the presented peptide but also the residues by which it is ...
Braciale, Chimini, Colbere-Garapin, Del Val, Del Val, Del Val, DeLisi, Falk, Falk, Ganem, Hans-Jürgen Schlicht, Jonjić, Junker, Keil, Margarita Del Val, Matthias J. Reddehase, Nassal, Ou, Parham, Ponta, Reddehase, Reddehase, Rothbard, Rötzschke, Rötzschke, Schlicht, Schlicht, Thomas Ruppert, Townsend, Townsend, Townsend, Townsend, Townsend, Ulrich H. Koszinowski, Van Bleek, Volkmer, Yewdell   +36 more
core   +1 more source

Cell‐penetrating peptides: Achievements and challenges in application for cancer treatment [PDF]

, 2014
One of the major hurdles to cure cancer lies in the low potency of currently available drugs, which could eventually be solved by using more potent therapeutic macromolecules, such as proteins or genes.
Aderem, Agarwal, Balzeau, Brugidou, Calnan, Choi, Chopra, Christiaens, Conner, Crombez, Cryan, Derossi, Derossi, Dietz, Dodd, Drin, Dubikovskaya, Dupont, El-Andaloussi, Elmquist, Ezzat, Fawell, Fisher, Frankel, Fretz, Fuente, Fulda, Futaki, Gros, Hajdu, Hamilton, Han, Harris, Heitz, Hollstein, Hosotani, Hutmacher, Inoue, Jain, Jarver, Jiang, Jiang, Joliot, Josephson, Juliano, Juliano, Kale, Kaplan, Kaufman, Khalil, Kim, Kim, Kleemann, Koppelhus, Koren, Kuan, Kushner, Kwon, Kwon, Lee, Lewin, Liggett, Lindgren, Los, Lu, Ludtke, Mae, Maiolo, Marty, Matsuzaki, Meade, Mei, Michiue, Michl, Moon, Morris, Morris, Mortensen, Myrberg, Nakamura, Nan, Oehlke, Oehlke, Olson, Olson, Park, Park, Patel, Pooga, Pouny, Pridgen, Prochiantz, Prochiantz, Ratner, Richard, Roach, Rousselle, Rousselle, Roux, Rudolph, Sawant, Scheller, Schwarze, Schwarze, Sethuraman, Shokolenko, Snyder, Snyder, Snyder, Stirpe, Stroh, Suk, Tkachenko, Torchilin, Torchilin, Torchilin, Torchilin, Tseng, Tunnemann, Vives, Vucic, Wadia, Wender, Winer, Yagi, Zasloff, Zhang, Zhang, Zhao   +128 more
core   +1 more source

Cellular Internalization of Human Calcitonin Derived Peptides in MDCK Monolayers: A Comparative Study with Tat(47-57) and Penetratin(43-58) [PDF]

, 2018
Purpose. The objective of this study was to evaluate key motif requirements of human calcitonin (hCT)-derived peptides for the permeation through the plasma membrane of MDCK monolayers, as epithelial model. Methods.
Beck-Sickinger, Annette, Krauss, Ulrike, Meinecke, Martina, Merkle, Hans, Muff, Roman, Tréhin, Rachel   +5 more
core  

UEG Week 2025 Oral Presentations

United European Gastroenterology Journal, Volume 13, Issue S8, Page S7-S188, October 2025.
wiley   +1 more source