Results 271 to 280 of about 1,821,948 (314)
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1995
If we include beta-lactam antibiotics on the grounds that they have the same biosynthetic origin, peptides remain commercially the most important group of pharmaceuticals. However, our increasing knowledge of the genetic and enzymic background to biosynthesis, and of the regulation of metabolite production, will eventually bring a more unified approach
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If we include beta-lactam antibiotics on the grounds that they have the same biosynthetic origin, peptides remain commercially the most important group of pharmaceuticals. However, our increasing knowledge of the genetic and enzymic background to biosynthesis, and of the regulation of metabolite production, will eventually bring a more unified approach
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Crystal structures of peptides and modified peptides
Biopolymers, 1996The X-ray diffraction experiments on peptides and related molecules which have been carried out in Western Europe, except Italy, in the last eight years are reviewed. The crystal structures of some bioactive peptides such as Leu-enkephalin (a neurotransmitter), cyclosporin A (an immunomodulator in both the free and protein-bound state), balhimycin (an ...
M, Marraud, A, Aubry
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Life Sciences, 1973
Evidence has accumulated that peptides influence behavior by acting on various structures in the brain. Peptides derived from the anterior pituitary (ACTH, growth hormone), the intermediate lobe (α-MSH), and the posterior lobe (vasopressin) of the pituitary have been shown to modulate conditioned behavior (DE WIED, 1969).
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Evidence has accumulated that peptides influence behavior by acting on various structures in the brain. Peptides derived from the anterior pituitary (ACTH, growth hormone), the intermediate lobe (α-MSH), and the posterior lobe (vasopressin) of the pituitary have been shown to modulate conditioned behavior (DE WIED, 1969).
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Dissociation of the peptide bond in protonated peptides
Journal of Mass Spectrometry, 2000The dissociation of the amide (peptide) bond in protonated peptides, [M + H](+), is discussed in terms of the structures and energetics of the resulting N-terminal b(n) and C-terminal y(n) sequence ions. The combined data provide strong evidence that dissociation proceeds with no reverse barriers through interconverting proton-bound complexes between ...
M J, Polce, D, Ren, C, Wesdemiotis
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Non-peptide ligands for peptide receptors
Trends in Pharmacological Sciences, 1989Considerable progress has been made in synthesizing peptide analogs with improved stability for probing function of peptide-receptor systems. However, since peptide ligands are usually unsuitable for development as potent orally active long-duration therapeutic agents, considerable research effort is being directed to the development of non-peptidal ...
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Gastroenterology Clinics of North America, 1989
The intent of this article is to summarize the primary structures (that is, amino acid sequences) localization, primary gastrointestinal and pancreatic actions, and possible clinical relevance of the major gut peptides as well as some of the miscellaneous gut peptides. A brief overview of the general characteristics of gut peptides is presented.
D W, Green, G, Gomez, G H, Greeley
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The intent of this article is to summarize the primary structures (that is, amino acid sequences) localization, primary gastrointestinal and pancreatic actions, and possible clinical relevance of the major gut peptides as well as some of the miscellaneous gut peptides. A brief overview of the general characteristics of gut peptides is presented.
D W, Green, G, Gomez, G H, Greeley
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Peptides: Locally Active Peptides (“Vasoactive Peptides”)
1982Angiotensin may be considered the prototype of the so-called vasoactive peptides inasmuch as its predominant effect is on vascular smooth muscle, which is constricted by both direct and indirect effects of the peptide. However, angiotensin may affect contractility of much extravascular smooth muscle with a predominantly, if not exclusively, stimulatory
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Critical Reviews in Toxicology, 2003
The article provides a broad assessment of the occurrence of hormetic-like biphasic dose-response relationships by over 30 peptides representing many major peptide classes. These peptide-induced biphasic dose responses were observed to occur in a extensive range of tissues, affecting an diverse range of biological endpoints.
Edward J, Calabrese, Linda A, Baldwin
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The article provides a broad assessment of the occurrence of hormetic-like biphasic dose-response relationships by over 30 peptides representing many major peptide classes. These peptide-induced biphasic dose responses were observed to occur in a extensive range of tissues, affecting an diverse range of biological endpoints.
Edward J, Calabrese, Linda A, Baldwin
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The FASEB Journal, 1995
Although most short, linear peptide fragments of proteins are unstructured in aqueous solution, a number of immunogenic and antigenic peptides have been shown to have conformational preferences for structured forms. By using mainly NMR and CD spectroscopy, it has been possible to detect and quantify quite small populations of β ...
H J, Dyson, P E, Wright
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Although most short, linear peptide fragments of proteins are unstructured in aqueous solution, a number of immunogenic and antigenic peptides have been shown to have conformational preferences for structured forms. By using mainly NMR and CD spectroscopy, it has been possible to detect and quantify quite small populations of β ...
H J, Dyson, P E, Wright
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Sex-peptides: seminal peptides of the Drosophila male
Cellular and Molecular Life Sciences (CMLS), 2003Uploaded by Plazi for TaxoDros. We do not have abstracts.
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