Results 61 to 70 of about 2,022,176 (307)

Emerging experimental and computational methods for studying redox‐regulated structural transitions

FEBS Letters, EarlyView.
Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass, Dana Reichmann, Gábor Erdős   +2 more
wiley   +1 more source

New s-Triazine–Hydrazone Hybrids Targeting EGFR: Design and Anticancer Activity Against A549 Lung Adenocarcinoma

Journal of Chemistry
A new series of pyridine–s-triazine–hydrazone derivatives was designed, synthesized via an efficient two-step route, and fully characterized by 1H-NMR, 13C-NMR, and elemental analyses.
Hessa H. Al-Rasheed, Sarah A. Al-Khamis, Assem Barakat, Aliaa A. Masoud, Ahmed A. Sobhy, Maha El Demellawy, Doaa A. Ghareeb, Anamika Sharma, Beatriz G. de la Torre, Fernando Albericio, Ayman El-Faham   +10 more
doaj   +1 more source

Crystal structure of butyl 2-(3,5-dimethyl-1,1-dioxido-2H-1,2,6-thiadiazin-4-yl)benzoate, C16H20N2O4S

Zeitschrift für Kristallographie - New Crystal Structures, 2016
C16H20N2O4S, monoclinic, P21/n (no. 14), a = 9.229(2) Å, b = 16.995(4) Å, c = 11.084(3) Å, β = 99.985(11)°, V = 1712.3(8) Å3, Z = 4, Rgt(F) = 0.0393, wRref(F2) = 0.1081, T = 173.
Bhatt Nilay, Samipillai Marivel, Bhatt Pralav, Govender Thavendran, Kruger Hendrik G., Maguire Glenn E.M.   +5 more
doaj   +1 more source

Feedback Inhibition of CREB Signaling Promotes Beta Cell Dysfunction in Insulin Resistance

Cell Reports, 2015
Although persistent elevations in circulating glucose concentrations promote compensatory increases in pancreatic islet mass, unremitting insulin resistance causes deterioration in beta cell function that leads to the progression to diabetes.
Emilie Blanchet, Sam Van de Velde, Shigenobu Matsumura, Ergeng Hao, John LeLay, Klaus Kaestner, Marc Montminy   +6 more
doaj   +1 more source

Natural killer cell-derived exosomal miR-1249-3p attenuates insulin resistance and inflammation in mouse models of type 2 diabetes

Signal Transduction and Targeted Therapy, 2021
Natural killer (NK) cells have been suggested to be associated with type 2 diabetes by regulating systemic inflammation. However, the mechanism by which NK cells regulate insulin sensitivity remains unknown. This study shows that NK-derived exosomes from
Ying Wang, Mengwei Li, Lin Chen, Huan Bian, Xiangying Chen, Huilin Zheng, Peiwei Yang, Quan Chen, Hanmei Xu   +8 more
doaj   +1 more source

Translophagy—A potential link between autophagy impairment and translational errors

FEBS Letters, EarlyView.
Neurodegenerative diseases are characterised by the accumulation of abnormal proteins and protein aggregates, but their origin often remains unknown. We propose that selective autophagy removes damaged protein‐making machinery, preventing errors during protein synthesis.
Mykola V. Korolchuk, Gailing Ma, Robin Antrobus, Diego Manni, Marco Trevisan‐Herraz, Mustafa Khwaja, Max Brown, Gavin D. Richardson, Masaaki Komatsu, Daniel Erskine, Viktor I. Korolchuk, Tetsushi Kataura   +11 more
wiley   +1 more source

Towards an understanding of peptide-inorganic interactions [PDF]

, 2013
This study has contributed to the developing understanding of fundamental principles through which interactions at peptide-inorganic interfaces occur. The inorganic materials; crystalline zinc oxide (ZnO) and platinum (Pt) together with specific binding ...
Limo, MJ
core  

Peptide-protein interaction similarity scores.

, 2019
Peptide-protein interaction similarity scores.
Atieh Hashemi (7610240), Kimia Kardani (7610237), Azam Bolhassani (403908)   +2 more
core   +1 more source

Functional comparison of EncB and EncC cargo proteins in iron storage within the Myxococcus xanthus encapsulin

FEBS Letters, EarlyView.
Encapsulins are protein nanocompartments that play an important role in iron storage. In the Myxococcus xanthus encapsulin system, two cargo proteins called EncB and EncC contribute to iron mineralization. Here, we show that EncB and EncC generate iron‐containing minerals with distinct chemical compositions, suggesting that the composition of stored ...
Harry B. McDowell, Thomas Walther, Egbert Hoiczyk   +2 more
wiley   +1 more source

Microprotein-encoding RNA regulation in cells treated with pro-inflammatory and pro-fibrotic stimuli

BMC Genomics
Background Recent analysis of the human proteome via proteogenomics and ribosome profiling of the transcriptome revealed the existence of thousands of previously unannotated microprotein-coding small open reading frames (smORFs).
Victor J. Pai, Calvin J. Lau, Almudena Garcia-Ruiz, Cynthia Donaldson, Joan M. Vaughan, Brendan Miller, Eduardo V. De Souza, Antonio M. Pinto, Jolene Diedrich, Narender R. Gavva, Shan Yu, Christopher DeBoever, Shane R. Horman, Alan Saghatelian   +13 more
doaj   +1 more source