eLife, 2021 The ability to regulate DNA replication initiation in response to changing nutrient conditions is an important feature of most cell types. In bacteria, DNA replication is triggered by the initiator protein DnaA, which has long been suggested to respond ...
Michele Felletti +3 more
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Ribosome crystallography: catalysis and evolution of peptide-bond formation, nascent chain elongation and its co-translational folding [PDF]
Biochemical Society Transactions, 2005 A ribosome is a ribozyme polymerizing amino acids, exploiting positional- and substrate-mediated chemical catalysis. We showed that peptide-bond formation is facilitated by the ribosomal architectural frame, provided by a sizable symmetry-related region in and around the peptidyl transferase centre, suggesting that the ribosomal active site was evolved
A, Bashan, A, Yonath
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Dual regulation of translation initiation and peptide chain elongation during BDNF‐induced LTP in vivo: evidence for compartment‐specific translation control [PDF]
Journal of Neurochemistry, 2006 AbstractProtein synthesis underlying activity‐dependent synaptic plasticity is controlled at the level of mRNA translation. We examined the dynamics and spatial regulation of two key translation factors, eukaryotic initiation factor 4E (eIF4E) and elongation factor‐2 (eEF2), during long‐term potentiation (LTP) induced by local infusion of brain‐derived
Tambudzai, Kanhema +9 more
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SecM-stalled ribosomes adopt an altered geometry at the peptidyl transferase center. [PDF]
PLoS Biology, 2011 As nascent polypeptide chains are synthesized, they pass through a tunnel in the large ribosomal subunit. Interaction between specific nascent chains and the ribosomal tunnel is used to induce translational stalling for the regulation of gene expression.
Shashi Bhushan +7 more
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Co-translational localization of an LTR-retrotransposon RNA to the endoplasmic reticulum nucleates virus-like particle assembly sites. [PDF]
PLoS Genetics, 2014 The transcript of retrovirus-like transposons functions as an mRNA for synthesis of capsid and replication proteins and as the genomic RNA of virus-like particles (VLPs), wherein the genome is replicated.
Jung H Doh, Sheila Lutz, M Joan Curcio
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The role of molecular chaperone CCT/TRiC in translation elongation: A literature review
HeliyonProtein synthesis from mRNA is an energy-intensive and strictly controlled biological process. Translation elongation is a well-coordinated and multifactorial step in translation that ensures the accurate and efficient addition of amino acids to a ...
Yueyue Que +6 more
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Co-translational protein targeting to mitochondria in the context of co-translational protein maturation. [PDF]
Protein SciKvasov NA, Bykov YS.
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Mitochondrial translational control in cardiovascular diseases: from mechanisms to therapies. [PDF]
Redox BiolDeng Y, Guo N, Li D, Wang Z.
europepmc +1 more source
Diverse mechanisms of translation arrest by a Clostridia ribosome stalling peptide CliM. [PDF]
Nat CommunYoshida M +11 more
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N-terminal formylmethionine as a degron and a specific signal in proteostasis and stress adaptation. [PDF]
Exp Mol MedLee CS, Kim D, Hwang CS.
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