Results 1 to 10 of about 51,181 (58)

A nascent polypeptide sequence modulates DnaA translation elongation in response to nutrient availability

eLife, 2021
The ability to regulate DNA replication initiation in response to changing nutrient conditions is an important feature of most cell types. In bacteria, DNA replication is triggered by the initiator protein DnaA, which has long been suggested to respond ...
Michele Felletti, Cédric Romilly, E Gerhart H Wagner, Kristina Jonas   +3 more
doaj   +1 more source

A 66 amino acid micro-peptide encoded by long non-coding RNA RP11-119F7.5 was identified in hepatocellular carcinoma

Journal of Bio-X Research, 2022
Objective:. Emerging data have shown that non-coding RNAs (ncRNAs) can encode micro-peptides (≤100 amino acids) that play an important role in regulating physiological and pathological processes.
Chengwen He, Zhiyong Liu, Yanan Pang, Yin Jia, Qin Qin, Ruijiao Kong, Hui Zhang, Shanrong Liu   +7 more
doaj   +1 more source

Molecular biology of the cell

Journal of Education, Health and Sport, 2022
The book is intended for students studying medical and biological specialties.     CHAPTER I. EPIGENETICS INTRODUCTION The science of epigenetics looks at the mechanisms of molecular modifications of histones and DNA that can regulate gene ...
Sergey Dolomatov, Elizaveta Ageeva, Walery Zukow   +2 more
doaj   +1 more source

SecM-stalled ribosomes adopt an altered geometry at the peptidyl transferase center. [PDF]

PLoS Biology, 2011
As nascent polypeptide chains are synthesized, they pass through a tunnel in the large ribosomal subunit. Interaction between specific nascent chains and the ribosomal tunnel is used to induce translational stalling for the regulation of gene expression.
Shashi Bhushan, Thomas Hoffmann, Birgit Seidelt, Jens Frauenfeld, Thorsten Mielke, Otto Berninghausen, Daniel N Wilson, Roland Beckmann   +7 more
doaj   +1 more source

Dual regulation of translation initiation and peptide chain elongation during BDNF‐induced LTP in vivo: evidence for compartment‐specific translation control [PDF]

Journal of Neurochemistry, 2006
AbstractProtein synthesis underlying activity‐dependent synaptic plasticity is controlled at the level of mRNA translation. We examined the dynamics and spatial regulation of two key translation factors, eukaryotic initiation factor 4E (eIF4E) and elongation factor‐2 (eEF2), during long‐term potentiation (LTP) induced by local infusion of brain‐derived
Tambudzai, Kanhema, Grethe, Dagestad, Debabrata, Panja, Adrian, Tiron, Elhoucine, Messaoudi, Bjarte, Håvik, Shui-Wang, Ying, Angus C, Nairn, Nahum, Sonenberg, Clive R, Bramham   +9 more
openaire   +2 more sources

Nonsense-mediated mRNA decay of mRNAs encoding a signal peptide occurs primarily after mRNA targeting to the endoplasmic reticulum

Molecules and Cells
: Translation of messenger ribonucleic acids (mRNAs) encoding integral membrane proteins or secreted proteins occurs on the surface of the endoplasmic reticulum (ER). When a nascent signal peptide is synthesized from the mRNAs, the ribosome-nascent chain
Min-Kyung Shin, Jeeyoon Chang, Joori Park, Hyuk-Joon Lee, Jae-Sung Woo, Yoon Ki Kim   +5 more
doaj   +1 more source

Constant trouble with prolines-navigating a global translation dilemma. [PDF]

Nucleic Acids Res
Lassak J, Stritzel J, Schlundt A, Brewer T.   +3 more
europepmc   +1 more source

Bridging single-molecule and genome-wide studies of cellular mRNA translation. [PDF]

RNA
Koch A, Tomuro K, Wakigawa T, Morisaki T, Iwasaki S, Stasevich TJ.   +5 more
europepmc   +1 more source

Expression of recombinant human glutamylating TTLLs in human cells leads to differential tubulin glutamylation patterns, with only TTLL6 disrupting microtubule dynamics. [PDF]

PLoS One
Al Kabbani MA, Jatoo P, Klebl AK, Klebl B, Zempel H.   +4 more
europepmc   +1 more source

Circularization and Ribosome Recycling: From Polysome Topology to Translational Control. [PDF]

Int J Mol Sci
Afonina ZA, Vassilenko KS.
europepmc   +1 more source