Results 251 to 260 of about 354,018 (307)

A FAP‐Targeted SMDC Platform Enables Synergistic Radionuclide–Chemotherapy with PET‐Guided Evaluation

Advanced Science, EarlyView.
A fibroblast activation protein (FAP)‐targeted small molecule–drug conjugate (SMDC) platform is developed to integrate PET imaging with synergistic radionuclide–chemotherapy. Linker chemistry governs stability, exposure, and tolerability, with the VC linker providing superior in vivo performance.
Ruitao Yang, Hongxin Li, Zexin Xu, Baocheng Chen, Ningjie Li, Yuhua Zhong, Kongzhen Hu   +6 more
wiley   +1 more source

Investigating the Efficiency of Ultraviolet Photodissociation in Peptides Modified with <i>N</i>-Terminal UV-Absorbing Chromophores. [PDF]

J Am Soc Mass Spectrom
Levin N, Demyanenko Y, Kitano E, Mohammed S.   +3 more
europepmc   +1 more source

Covalent Reprogramming of Kinase Binders to Modulate Protein Abundance

Advanced Science, EarlyView.
Electrophilic remodeling of a broad‐spectrum kinase binder reveals how subtle chemical changes reprogram protein fate. An acrylamide analog of a multi‐kinase binder selectively stabilizes Aurora kinase A (AURKA) by suppressing its ubiquitination, while a short‐linker variant converts this stabilizer into a degrader.
Chen Mozes, Xiaokang Jin, Miguel A. Campos, Chen Zhou, Xiaoyu Zhang   +4 more
wiley   +1 more source

HERVOminer: a sequence similarity-based approach for recognizing endogenous retrovirus origin of the peptidome. [PDF]

NPJ Precis Oncol
Wu CH, Fok TW, Huang KC, Tsai MH, Lai LC, Lu TP, Chao KSC, Chuang EY, Lee CY.   +8 more
europepmc   +1 more source

A Dual‐Functional Biohybrid Nanorobot to Synergistically Eradicate Biofilm and Degrade Antibiotic Resistance Genes

Advanced Science, EarlyView.
A biohybrid nanorobot integrating lytic bacteriophage N4 with Pd nanozymes is developed for targeted eradication of multidrug‐resistant E. coli biofilms. Synergistic bacterial lysis and ROS‐mediated oxidation enable simultaneous biofilm removal and antibiotic resistance genes degradation, maintaining high efficacy in complex wastewater environments ...
Junzheng Zhang, Tong Dou, Luokai Wang, Jingxian Yang, Wenrui Wang, Shuaitian Guo, Xiangyu Li, Xuefang Huang, Yunlei Xianyu, Dongsheng Wang   +9 more
wiley   +1 more source

Probing the Influence of Sulfur-Aromatic Interactions on the Electronic Structure of Gas-Phase Peptides. [PDF]

Chemistry
Pille L, Ortiz-Mahecha C, Oostenrijk B, Leroux J, Girod M, Hirsch K, MacAleese L, Meißner RH, Scuderi D, Unger I, Zamudio-Bayer V, Bari S, Schwob L.   +12 more
europepmc   +1 more source

Dynamic Self‐Clickable Decellularized Matrix Hydrogels for Regulating Vascularity and Enhancing Muscle Regeneration

Advanced Science, EarlyView.
Dynamic decellularized hydrogels are prepared using bovine decellularized small intestine submucosa (SIS) norbornene (dSIS‐NB). Bovine dSIS contained significant amounts of disulfide‐rich fibrillin‐I, enabling ‘self‐clickable’ thiol‐norbornene gelation and spatiotemporal tuning of hydrogel physicochemical properties.
Van Thuy Duong, Tuba Marjan, Ngoc Ha Luong, Taimoor H. Qazi, Chien‐Chi Lin   +4 more
wiley   +1 more source

Dipeptide Transport Systems at the Interface of Peptide Metabolism and Drug Delivery in Cancer. [PDF]

Int J Mol Sci
Kim KH, Yoo BC.
europepmc   +1 more source

Multifunctional Peptides from Equine Milk Lactoferrin: Evaluation of Antimicrobial Activity In Silico and In Vitro. [PDF]

Animals (Basel)
Narmuratova M, Atambayeva S, Kaiyrmanova G, Orazova S, Narmuratova G, Faye B.   +5 more
europepmc   +1 more source

P450 Cyptide Synthase AscB Catalyzes Fused Cyclophane at the YxWxH Motif on the Precursor Peptides. [PDF]

Org Lett
Haedar JR, Khan AH, Gullick J, Hansen MH, Coe LJ, De Voss JJ, Romanuks V, Smits G, Donadio S, Cryle MJ, Phan CS.   +10 more
europepmc   +1 more source