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Characteristics of Cell-Penetrating Peptide/Nucleic Acid Nanoparticles.
Molecular Pharmaceutics, 2016Nucleic acids are highly promising candidates for the treatment of various genetic diseases. However, due to the large size and negative charge, nucleic acids are not efficiently taken up by cells, and thus, their clinical potential remains limited so ...
Helerin Margus +3 more
semanticscholar +1 more source
Scanning of 16S Ribosomal RNA for Peptide Nucleic Acid Targets.
Journal of Physical Chemistry B, 2016We have designed a protocol and server to aid in the search for putative binding sites in 16S rRNA that could be targeted by peptide nucleic acid oligomers.
A. Górska +3 more
semanticscholar +1 more source
Journal of the American Chemical Society, 2014
The use of stimuli-responsive bioactive molecules is an attractive strategy to circumvent selectivity issues in vivo. Here, we report an activatable cell penetrating peptide (CPP) strategy ultimately aimed at delivering nucleic acid drugs to the colon ...
Soo Hyeon Lee +3 more
semanticscholar +1 more source
The use of stimuli-responsive bioactive molecules is an attractive strategy to circumvent selectivity issues in vivo. Here, we report an activatable cell penetrating peptide (CPP) strategy ultimately aimed at delivering nucleic acid drugs to the colon ...
Soo Hyeon Lee +3 more
semanticscholar +1 more source
Bifacial peptide nucleic acid as an allosteric switch for aptamer and ribozyme function.
Journal of the American Chemical Society, 2014We demonstrate herein that bifacial peptide nucleic acid (bPNA) hybrid triplexes functionally substitute for duplex DNA or RNA. Structure-function loss in three non-coding nucleic acids was inflicted by replacement of a duplex stem with unstructured ...
Xin Xia, Xijun Piao, D. Bong
semanticscholar +1 more source
Self-Assembly of Hybridized Peptide Nucleic Acid Amphiphiles.
ACS Macro Letters, 2014In this report, a series of peptide nucleic acid amphiphiles (PNAAs) with hybridization properties were designed and synthesized. Driven by hydrophobic interaction, the hybridized PNAAs can form uniform micelles, the base stacking interaction from PNA ...
Li‐Han Liu +8 more
semanticscholar +1 more source
Peptides, polypeptides and peptide-polymer hybrids as nucleic acid carriers.
Biomaterials Science, 2017Cell penetrating peptides (CPPs), and protein transduction domains (PTDs) of viruses and other natural proteins serve as a template for the development of efficient peptide based gene delivery vectors.
Marya Ahmed
semanticscholar +1 more source
ACS Nano, 2013
MicroRNA (miRNA) is an important small RNA which regulates diverse gene expression at the post-transcriptional level. miRNAs are considered as important biomarkers since abnormal expression of specific miRNAs is associated with many diseases including ...
Soo-Ryoon Ryoo +10 more
semanticscholar +1 more source
MicroRNA (miRNA) is an important small RNA which regulates diverse gene expression at the post-transcriptional level. miRNAs are considered as important biomarkers since abnormal expression of specific miRNAs is associated with many diseases including ...
Soo-Ryoon Ryoo +10 more
semanticscholar +1 more source
Peptide nucleic acids harness dual information codes in a single molecule.
Chemical Communications, 2020Nature encodes the information required for life in two fundamental biopolymers: nucleic acids and proteins. Peptide nucleic acid (PNA), a synthetic analog comprised of nucleobases arrayed along a pseudopeptide backbone, has the ability to combine the ...
Colin S. Swenson, J. Heemstra
semanticscholar +1 more source
Angewandte Chemie, 2013
Cut loose: A pseudocomplementary peptide nucleic acid was tethered to a pyrrole/imidazole hairpin polyamide, and was used to selectively target a specific DNA sequence. Binding even occurs under high salt conditions.
Wataru Kameshima +6 more
semanticscholar +1 more source
Cut loose: A pseudocomplementary peptide nucleic acid was tethered to a pyrrole/imidazole hairpin polyamide, and was used to selectively target a specific DNA sequence. Binding even occurs under high salt conditions.
Wataru Kameshima +6 more
semanticscholar +1 more source