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Role of SbmA in the uptake of peptide nucleic acid (PNA)-peptide conjugates in E. coli.
ACS Chemical Biology, 2013Antisense PNA oligomers targeting essential genes (acpP or ftsZ) and conjugated to the delivery peptide L((KFF)(3)K) show complete growth inhibition of wild type E. coli strain (MG1655) with submicromolar MIC. In this study we show that resistant mutants
A. Ghosal +3 more
semanticscholar +1 more source
Effect of backbone flexibility on charge transfer rates in peptide nucleic acid duplexes.
Journal of the American Chemical Society, 2012Charge transfer (CT) properties are compared between peptide nucleic acid structures with an aminoethylglycine backbone (aeg-PNA) and those with a γ-methylated backbone (γ-PNA). The common aeg-PNA is an achiral molecule with a flexible structure, whereas
E. Wierzbiński +12 more
semanticscholar +1 more source
Pyrrolidinyl peptide nucleic acid homologues: effect of ring size on hybridization properties.
Organic Letters, 2012The effect of ring size of four- to six-membered cyclic β-amino acid on the hybridization properties of pyrrolidinyl peptide nucleic acid with an alternating α/β peptide backbone is reported.
Woraluk Mansawat +4 more
semanticscholar +1 more source
Two-color fluorescent l-amino acid mimic of tryptophan for probing peptide-nucleic acid complexes.
Bioconjugate chemistry, 2012Non-natural amino acids are important tools for site-selective probing of peptide properties and interactions. Here, for the first time a fluorescent l-amino acid, exhibiting excited-state intramolecular proton transfer (ESIPT) and hydration-sensitive ...
A. V. Strizhak +7 more
semanticscholar +1 more source
Electrochemical paper-based peptide nucleic acid biosensor for detecting human papillomavirus.
Analytica Chimica Acta, 2017Prinjaporn Teengam +5 more
semanticscholar +1 more source