Results 121 to 130 of about 1,944,940 (311)

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

open access: yesMolecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang   +12 more
wiley   +1 more source

Assessing Perceived Benefits and Perceived Barriers to Students’ Physical Activities

open access: yesInformation Management and Business Review
Physical activity is essential for maintaining individual health through indoor or outdoor activities. Whether the individual or group initiates it, the physical activity should be encouraged and included for students at the university. However, students encounter various barriers that hinder their engagement, including time limitations, a lack of ...
Nor Zaihan Mat Hasan Mat Hussin   +2 more
openaire   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

open access: yesMolecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla   +9 more
wiley   +1 more source

ISO 9000: Link between Seeking Certification and Perceived Benefit [PDF]

open access: yes, 2004
This paper presents the result of a study on perceived benefits of obtaining ISO 9000 certification. In addition, the link between the intentions of seeking ISO certification with perceived benefit was explored.
Yahya, Salleh
core  

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

open access: yesMolecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch   +13 more
wiley   +1 more source

Factors Associated with the Use of Human Papillomavirus Vaccination in Women: A New Evidence from in Surakarta, Central Java [PDF]

open access: yes, 2018
Background: Cervical cancer ranked fourth against most women’s cancer worldwide. The incidence of cervical cancer was estimated at 528,000 (7.9%) cases in the world causing 266,000 deaths in 2012. Cervical cancer is caused by a human papilloma-virus (HPV)
Adriani, R. B. (Rita)   +2 more
core  

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

open access: yesMolecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni   +11 more
wiley   +1 more source

An app for personal searches:more-private, non-volatile searches with stigmergic inspiration [PDF]

open access: yes, 2017
Web searching has long become a ubiquitous behavior amongst Internet users. Much has been changing: odds are that the thousands of results of yesterday have become millions of results today, but did that significant jump in quantity translate to an ...
Marques, Artur
core  

Perceived benefits from enterprise architecture

open access: yes, 2014
Enterprise Architecture has been developed in order to optimize the alignment between business needs and the (rapidly changing) possibilities of information technology. But do organizations indeed benefit from the application of Enterprise Architecture according to those who are in any way involved in architecture?
Slot, Raymond   +2 more
openaire  

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