Results 61 to 70 of about 404,793 (262)
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
Perceived Benefits of Nature in Diverse Populations
International Journal of Environmental Research and Public HealthThe relationship between socioeconomic and demographic characteristics and health effects of green spaces has been studied suggesting that certain groups, such as men, may get more health benefits from nature exposure. However, the link between perceived benefits of nature and socioeconomic and demographic characteristics remains a gap in literature ...
Joy L. Hart +5 more
openaire +2 more sources
FEBS Letters, EarlyView.How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley +1 more source
Exploring SRI Intention In Young Investors: Benefit, Norms, and Government Support
Value: Jurnal Manajemen dan AkuntansiSustainable Responsible Investment (SRI) has gained greater recognition as young investors show increased interest in green issues, incorporating environmental, social and governance (ESG) criteria alongside financial objectives in response to growing ...
Dwi Martutiningrum +1 more
doaj +1 more source
Profit: Jurnal Administrasi Bisnis, 2019  This research aimed to examine the perceptions of taxpayers in applying the Annual Tax Return e-Filing system with the approach of Decomposed Theory of Planned Behavior (DTPB) model by Taylor and Todd (1995). This research is the development of the ...
Latifah Hanum
doaj +1 more source
Metastatic niche shaped by host factors influences disseminated cancer cell fate
FEBS Letters, EarlyView.Metastasis is shaped not only by cancer cells but also by the environments they encounter. This review explores how factors such as aging, diet, the microbiome, lifestyle, and environmental exposures remodel organ‐specific niches in the lung, liver, bone, and brain, influencing where metastatic cells survive, remain dormant, or grow, and ultimately ...
Gwennan Delyth Ward +2 more
wiley +1 more source
Determinants of Tax Evasion in Micro Small Medium Enterprises: An Explanation of Ethics Theory
Jurnal ProaksiMain Purpose - The purpose of this study was to examine the effect of perceived benefits and moral obligations on tax evasion by Micro, Small, and Medium Enterprises. Method - This research is a quantitative study with a survey method.
Selfira Salsabilla
doaj +1 more source
Frontiers in Psychiatry, 2020 COVID-19 has brought tremendous and abrupt threats to various aspects of our daily lives, from school and work to interpersonal relationships. Self-compassion is put forth as a salutogenic perspective on oneself that buffers the adverse mental health ...
Bobo Hi-Po Lau +2 more
doaj +1 more source
Demographic differences in perceived benefits from gamification
Computers in Human Behavior, 2014 In recent years, ‘‘gamification’’ has been proposed as a solution for engaging people in individually and socially sustainable behaviors, such as exercise, sustainable consumption, and education. This paper studies demographic differences in perceived benefits from gamification in the context of exercise.
Jonna Koivisto, Juho Hamari
openaire +2 more sources
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source