Results 91 to 100 of about 4,041,072 (252)

Perceived medication benefits and their association with interest in using inhaled insulin in type 2 diabetes: a model of patients' cognitive framework

, 2011
Mark Peyrot1,2, Richard R Rubin2,31Department of Sociology, Loyola University, MD, USA; 2Department of Medicine, 3Department of Pediatrics, Johns Hopkins University, Baltimore, MD, USAObjective: To examine predictors of patient perceived relevance of ...
Rubin RR, Peyrot M
core  

Perceived benefits and barriers to physical activity in midlife Australian women: Results from the Women’s Wellness Program Trial©. [PDF]

, 2014
Background\ud \ud - Chronic diseases like cardiovascular disease and type 2 diabetes are an increasing cause of death and disability globally1. These diseases are largely preventable and are related to physical inactivity, unhealthy diet and smoking2 ...
Seib, Charrlotte, McGuire, Amanda Mary, Anderson, Debra J.   +2 more
core   +1 more source

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

Molecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park, Kyongman An, Gyeonghwa Kim, Soo‐Nyun Choi, Hong‐Ki Lee, Keun Hur, Kyu‐Shik Jeong   +6 more
wiley   +1 more source

Assessing Community Readiness and Benefits of a Nursing Program: Implications for Healthcare and Education

Jurnal Keperawatan Indonesia
In response to recent policy shifts allowing the establishment of new nursing programs in the Philippines, this study assesses the perceived readiness of Sorsogon, a geographically underserved province, to implement a bachelor of science in nursing ...
Mary Anne Frances D. Reyes, Aaron A. Funa, Robert Jamisola, Ma Joahna D. Perdigon, Jerica D. Latonero   +4 more
doaj   +1 more source

Targeting transcription factors associated with hemoglobinopathies: Lessons from successful interventions and implications for cancer

Molecular Oncology, EarlyView.
This review summarizes the transcription factors, repressive chromatin‐modifying complexes, and epigenetic mechanisms that control fetal hemoglobin repression. Notably, many regulators of γ‐globin silencing also function in transcriptional and epigenetic networks that drive cancer, highlighting opportunities to translate advances in hemoglobinopathy ...
Meigen Yu, Puspa Das, Xing Zhang, Xiaodong Cheng   +3 more
wiley   +1 more source

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

Molecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas, Barbara Karakyriakou, Patricia C. Muskus, Alyssa M. Roberts, Justin Rendleman, Alexa Warren, Hanxu Lu, Kimberly A. Birmingham, Malone K. Friedman, Abigail E. Goen, Huijuan Yang, Owen M. Wilkins, Fred W. Kolling, Eugene Demidenko, Julie M. Jorns, Brock C. Christensen, Todd W. Miller   +16 more
wiley   +1 more source

PANoptosis in the pathogenesis of myelodysplastic syndromes

Molecular Oncology, EarlyView.
PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla, Jyoti Lamichhane, Cameron Lewis, Peter Breslin, Jiwang Zhang   +4 more
wiley   +1 more source

Drivers of AI adoption in auditing: a quantitative exploration of perceived benefits and trust across auditor profiles

Cogent Business & Management
As artificial intelligence (AI) continues to transform the auditing profession, understanding the drivers of its adoption is particularly important in resource-constrained and volatile contexts such as Lebanon.
Nada Jabbour Al Maalouf, Abdallah Ficani, Jean Elia   +2 more
doaj   +1 more source

Castration‐resistant prostate cancer cells are addicted to the high activity of cyclin‐dependent kinase 2

Molecular Oncology, EarlyView.
We show that emergence of castration‐resistant prostate (CRPC) is associated with significant upregulation of cyclins that positively regulate cyclin‐dependent kinase 2 (CDK2) and concomitant downregulation of CDK4 cyclins. This renders CRPC cells dependent on the high activity of CDK2, and CDK2 inhibitors synergistically sensitize CRPC cells to both ...
Joyeeta Chatterjee, Alessia Marin, Shivani Yalala, Harri M. Itkonen   +3 more
wiley   +1 more source

Seeking Benefits or Avoiding Risks? Public Opinion Content and Consumers’ Purchase Intention Toward Aquatic Products: The Case of Basa Fish

Foods
Information asymmetry in aquatic product markets heightens consumers’ perceived food safety risks. Using basa fish as the focal product, this study examined how public opinion content influences purchase intention through perceived benefits and perceived
Xiaoyan Wang, Jianbo Luo, Yizhuo Zhang, Xiang Gao, Yongxiang Zhang, Yue Sun, Lejun Xu   +6 more
doaj   +1 more source