Results 111 to 120 of about 2,975,264 (300)

Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer

Molecular Oncology, EarlyView.
Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim, Maryam Aslam, Elouise Torruella, Alphons Sony, Asif Rahman, Simira Smith, Columba de la Parra, Moira Sauane   +7 more
wiley   +1 more source

Acknowledgement to Reviewers of Risks in 2016

, 2017
The editors of Risks would like to express their sincere gratitude to the following reviewers for assessing manuscripts in 2016.
Risks Editorial Office
core   +1 more source

scientific, social, ecological rationality and public attitudes toward genetically modified food in China: based on the survey of urban residents in three cities of China

GM Crops & Food
Genetically modified (GM) technology is crucial for global food security, but its acceptance is often constrained by public attitudes. This study investigates how three types of rationality (scientific, social, and ecological) are associated with ...
Hui Li, Zhenjing Pang, Tian Yu
doaj   +1 more source

Perceived risks, challenges and coping strategies among West African immigrant entrepreneurs in Ghana. [PDF]

Heliyon, 2023
Yendaw E, Baatiema L, Ameyaw EK.
europepmc   +1 more source

The VHL tumor suppressor at the crossroad of protein folding, aggregation, and cancer

Molecular Oncology, EarlyView.
Mutations, environmental stress, and chaperone dysfunction can destabilize pVHL, promoting its conversion from the native folded state into amyloid‐like assemblies. This transition may contribute to protein storage, cell dormancy, survival, and drug resistance.
Lara Abad, Silvio Carlo Ermanno Tosatto, Emanuela Leonardi   +2 more
wiley   +1 more source

Regulation of the lncRNA NEAT1 by p53‐ΔNp63 crosstalk modulates the DNA damage response and therapeutic efficacy in HNSCC

Molecular Oncology, EarlyView.
In head and neck squamous cell carcinoma (HNSCC) p53 and p63 exert opposite roles on the transcription regulation of the lncRNA NEAT1. Under basal conditions, p53 levels are low and p63 represses NEAT1 expression. Upon genotoxic stress, p53 is rapidly induced, displacing p63 from the NEAT1 promoter leading to NEAT1 transcriptional activation and ...
Sara De Domenico, Veronica La Banca, Silvia D'Amico, Stefano Scalera, Sara Nicolai, Angelo Peschiaroli   +5 more
wiley   +1 more source

Audit quality, ifrs and perceived bank risks under heterogeneous regulations

, 2013
The recent turmoil in global financial markets has accentuated the need to better understand the underlying bank risks and their determinants. A vast literature has emerged to analyse this issue in depth.
POZZA, LORENZO, PETTINICCHIO, ANGELA KATE, M. Zagonov, PROVASOLI, ANGELO   +3 more
core  

Does intergenerational economic support reduce the perception of pension risk among ecological migrants? – evidence from China

Technological and Economic Development of Economy
Understanding the influence of intergenerational economic support on ecological migrants’ perceived pension risks is essential. It provides a basis for designing targeted pension security systems and promoting sustainable livelihoods.
Jiangxia Hu, Yulong Luo
doaj   +1 more source

Automated FRAP microscopy for high‐throughput analysis of protein dynamics in chromatin organization and transcription

FEBS Open Bio, EarlyView.
RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz, Bart Geverts, Johan A. Slotman, Andrea Sacchetti, Stefan Prekovic, Martin E. van Royen, Adriaan B. Houtsmuller   +6 more
wiley   +1 more source

Perception of the Risks Associated with Impaired Driving and Effects on Driving Behavior [PDF]

This research studies the perception of the risks associated with impaired driving-probability of being apprehended or of having an accident-and the relation between the perception of risks and driving behavior.
Georges Dionne, Denise Desjardins, Claude Fluet   +2 more
core