Results 21 to 30 of about 4,144,787 (187)

TRPM8 levels determine tumor vulnerability to channel agonists

Molecular Oncology, EarlyView.
TRPM8 is a Ca2+ permissive channel. Regardless of the amount of its transcript, high levels of TRPM8 protein mark different tumors, including prostate, breast, colorectal, and lung carcinomas. Targeting TRPM8 with channel agonists stimulates inward calcium currents followed by emptying of cytosolic Ca2+ stores in cancer cells.
Alessandro Alaimo, Francesco Giuseppe Carbone, Kristi Buzo, Nicole Annesi, Sacha Genovesi, Annalisa Lorenzato, Karen Widmann, Michela Libergoli, Elisa Marmocchi, Giovanni Bertalot, Alberto Brolese, Mauro Giulio Papotti, Luca Molinaro, Orazio Caffo, Mattia Barbareschi, Alberto Bardelli, Alessandro Romanel, Sabrina Arena, Andrea Lunardi   +18 more
wiley   +1 more source

A User Perception Model Concerning Safety and Security of Paratransit Services in Bandung, Indonesia [PDF]

, 2005
Safety and security in public transportation, Angkutan Kota or paratransit included, are among the commonly poor aspects in Indonesia. The objective of this research is to describe user perception of safety and security aspects in paratransit operation ...
Joewono, T. B. (Tri), Kubota, H. (Hisashi)   +1 more
core  

Molecular imaging predicts trastuzumab‐deruxtecan (T‐DXd) response in head and neck cancer xenograft models

Molecular Oncology, EarlyView.
Trastuzumab‐deruxtecan, a HER2‐targeting antibody‐drug conjugate, shows promising antitumor activity in head and neck squamous cell carcinoma with low HER2 expression. In vitro and in vivo studies demonstrated dose‐dependent cell death and tumor growth reduction in low HER2‐expressing cell lines, which correlated with drug accumulation measured using a
Abdullah Bin Naveed, Lucas Mani, Muhammad Bilal Mirza, Ashtyn McAdoo, Takahito Kondo, Hidenori Tanaka, Nicole Meeks, Eben Rosenthal, Marisa Hom   +8 more
wiley   +1 more source

Smoothness perception : investigation of beat rate effect on frame rate perception [PDF]

, 2013
Despite the complexity of the Human Visual System (HVS), research over the last few decades has highlighted a number of its limitations. These limitations can be exploited in computer graphics to significantly reduce computational cost and thus required ...
Chalmers, Alan, Debattista, Kurt, Hulusić, Vedad   +2 more
core   +1 more source

Understanding and measuring mechanical signals in the tumor stroma

FEBS Open Bio, EarlyView.
This review discusses cancer‐associated fibroblast subtypes and their functions, particularly in relation to extracellular matrix production, as well as the development of 3D models to study tumor stroma mechanics in vitro. Several quantitative techniques to measure tissue mechanical properties are also described, to emphasize the diagnostic and ...
Fàtima de la Jara Ortiz, Chiara Cimmino, Maurizio Ventre, Alessandra Cambi   +3 more
wiley   +1 more source

Form Perception [PDF]

, 2007
National Science Foundation (SBE-0354378); Office of Naval Research (N00014-01-1 ...
Grossberg, Stephen
core   +1 more source

Impaired perception of biological motion in Parkinson’s disease [PDF]

, 2016
OBJECTIVE: We examined biological motion perception in Parkinson’s disease (PD). Biological motion perception is related to one’s own motor function and depends on the integrity of brain areas affected in PD, including posterior superior temporal sulcus.
Cronin-Golomb, Alice, Jaywant, Abhishek, Roy, Serge, Shiffrar, Maggie   +3 more
core   +1 more source

White Christian Nationalism: Adult Education and Threats to Democracy

New Directions for Adult and Continuing Education, EarlyView.
ABSTRACT Adult education has a historical and ongoing commitment to fostering democratic relationships, demonstrated by the tendency of adult education to be called upon when social change and realignment are most desirable. This article considers the philosophical and pragmatic possibilities for adult education at this moment, when White Christian ...
Ralf St. Clair, Lyn Tett, Rob Black
wiley   +1 more source

Perception of Community Health Workers in Indonesia Toward Patients with Mental Disorders [PDF]

, 2016
In Indonesia, there are any community health volunteers called Kader. Although Kaders are members of mental health volunteer, they sometimes show negative attitude to psychotic persons, even they have already got some training about mental health.
Kageyama, T. (Takayuki), Wardaningsih, S. (Shanti)   +1 more
core  

Adult Education Confronting White Christian Nationalism: A Thematic Analysis

New Directions for Adult and Continuing Education, EarlyView.
ABSTRACT As a way to conclude, this article elaborates key themes that emerged from the collected articles in this volume. Each article carries its own important message about the role of adult education in confronting White Christian nationalism, while here, Prins and Carr‐Chellman offer a thematic interpretation of the volume as a whole. These themes
Esther Prins, Davin Carr‐Chellman
wiley   +1 more source