Results 61 to 70 of about 1,931,146 (299)

Molecular bases of circadian magnesium rhythms across eukaryotes

FEBS Letters, EarlyView.
Circadian rhythms in intracellular [Mg2+] exist across eukaryotic kingdoms. Central roles for Mg2+ in metabolism suggest that Mg2+ rhythms could regulate daily cellular energy and metabolism. In this Perspective paper, we propose that ancestral prokaryotic transport proteins could be responsible for mediating Mg2+ rhythms and posit a feedback model ...
Helen K. Feord, Gerben van Ooijen
wiley   +1 more source

The newfound relationship between extrachromosomal DNAs and excised signal circles

FEBS Letters, EarlyView.
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley   +1 more source

Bridging the gap: Multi‐stakeholder perspectives of molecular diagnostics in oncology

Molecular Oncology, EarlyView.
Although molecular diagnostics is transforming cancer care, implementing novel technologies remains challenging. This study identifies unmet needs and technology requirements through a two‐step stakeholder involvement. Liquid biopsies for monitoring applications and predictive biomarker testing emerge as key unmet needs. Technology requirements vary by
Jorine Arnouts, Senada Koljenović, Elise Daems, Karolien De Wael, Marc Peeters, Léon C. van Kempen, Greetje Vanhoutte, Karen Zwaenepoel, Timon Vandamme   +8 more
wiley   +1 more source

Fully Dense Multiscale Fusion Network for Hyperspectral Image Classification

Remote Sensing, 2019
The convolutional neural network (CNN) can automatically extract hierarchical feature representations from raw data and has recently achieved great success in the classification of hyperspectral images (HSIs).
Zhe Meng, Lingling Li, Licheng Jiao, Zhixi Feng, Xu Tang, Miaomiao Liang   +5 more
doaj   +1 more source

Multi-Resolution Prediction Model Based on Community Relevance for Missing Links Prediction

IEEE Access, 2020
The existing research demonstrates that the link prediction algorithm which based on community similarity has better prediction performance than that of other node similarity-based methods, and it is more suitable for predicting the probability of the ...
Jingyi Ding, Jian Song, Licheng Jiao, Jianshe Wu, Fang Liu   +4 more
doaj   +1 more source

Intein‐based modular chimeric antigen receptor platform for specific CD19/CD20 co‐targeting

Molecular Oncology, EarlyView.
CARtein is a modular CAR platform that uses split inteins to splice antigen‐recognition modules onto a universal signaling backbone, enabling precise, scarless assembly without re‐engineering signaling domains. Deployed here against CD19 and CD20 in B‐cell malignancies, the design supports flexible multi‐antigen targeting to boost T‐cell activation and
Pablo Gonzalez‐Garcia, Noelia Moares, Wenjie Yi‐He, Rosa Luna‐Espejo, Ricardo Fernandez‐Cisnal, Javier Ocaña‐Cuesta, Juan P. Muñoz‐Miranda, Antonio Gabucio, Cecilia M. Fernandez‐Ponce, Francisco Garcia‐Cozar   +9 more
wiley   +1 more source

Change Detection in Remote Sensing Images Based on Image Mapping and a Deep Capsule Network

Remote Sensing, 2019
Homogeneous image change detection research has been well developed, and many methods have been proposed. However, change detection between heterogeneous images is challenging since heterogeneous images are in different domains.
Wenping Ma, Yunta Xiong, Yue Wu, Hui Yang, Xiangrong Zhang, Licheng Jiao   +5 more
doaj   +1 more source

Discriminative Sketch Topic Model With Structural Constraint for SAR Image Classification

IEEE Journal of Selected Topics in Applied Earth Observations and Remote Sensing, 2020
Synthetic aperture radar (SAR) image classification is an important part in the understanding and interpretation of SAR images. Each patch in SAR images has a scene category, but usually contains multiple land-cover classes or latent properties, which ...
Yake Zhang, Fang Liu, Licheng Jiao, Shuyuan Yang, Lingling Li, Meijuan Yang   +5 more
doaj   +1 more source

Actin dynamics controlled by IqgC, a RasGAP at the crossroads between the IQGAP and fungal GAP1 families

FEBS Open Bio, EarlyView.
IqgC is a RasGAP from Dictyostelium discoideum. IqgC binds RasG via its RasGAP domain and deactivates it on macroendocytic cups, thereby suppressing the uptake of fluid and particles. IqgC has a positive effect on cell‐substratum adhesion, and its RGCt domain is required for recruitment to ventral foci.
Vedrana Filić, Darija Putar, Lucija Mijanović, Igor Weber   +3 more
wiley   +1 more source

Scattering of Electromagnetic Wave by system of core/shell microsphere and nanoparticle

Advanced Electromagnetics, 2020
The paper deals with the scattering of an electromagnetic plane wave by a system of core/shell microspheres and a single nanoparticle placed outside the spheres.
A. Abramov, A. Kostikov, Y. Yue
doaj   +1 more source