Results 51 to 60 of about 1,363 (228)

RIPK3 dampens mitochondrial bioenergetics and lipid droplet dynamics in metabolic liver disease

Hepatology, EarlyView., 2022
RIPK3 dampens mitochondrial bioenergetics and lipid droplet dynamics in metabolic liver disease. Abstract Background and Aims Receptor‐interacting protein kinase 3 (RIPK3) mediates NAFLD progression, but its metabolic function is unclear. Here, we aimed to investigate the role of RIPK3 in modulating mitochondria function, coupled with lipid droplet (LD)
Marta B. Afonso, Tawhidul Islam, Julie Magusto, Ricardo Amorim, Véronique Lenoir, Rui F. Simões, José Teixeira, Liana C. Silva, Dominique Wendum, Isabelle Jéru, Corinne Vigouroux, Rui E. Castro, Paulo J. Oliveira, Carina Prip‐Buus, Vlad Ratziu, Jérémie Gautheron, Cecília M. P. Rodrigues   +16 more
wiley   +1 more source

Ultrasound‐Actuated Gene Editing in Human Kidney Organoids

Advanced Science, EarlyView.
Peptide‐stabilized nanoemulsions enable spatially controlled, ultrasound‐triggered delivery of gene‐editing proteins deep within human kidney organoid tissues. Focused acoustic pulses drive droplet vaporization, propelling cargo into target renal cells while preserving native tissue microarchitecture. This non‐viral platform improves both the depth and
Michael A. Miller, Nicole Vo, Utkarsh, Ivan Sokirniy, Justin Pritchard, Benjamin S. Freedman, Scott H. Medina   +6 more
wiley   +1 more source

2,6-Diethylanilinium perchlorate [PDF]

Acta Crystallographica Section E Structure Reports Online, 2010
The asymmetric unit of the title mol-ecular salt, C(10)H(16)N(+)·ClO(4) (-), contains two cations and two anions. The atoms of one of the ethyl side chains of one of the cations are disordered over two sets of sites in a 0.531 (13):0.469 (13) ratio. In the crystal, the components are linked by N-H⋯O and bifurcated N-H⋯(O,O) hydrogen bonds and weaker C ...
Salem S. Al-Deyab, Mohamed Rzaigui, Wajda Smirani Sta   +2 more
openaire   +3 more sources

A Catalytic Osmium Redox Couple Collapses Cancer Redox Balance

Advanced Science, EarlyView.
A stable Os(III)/Os(IV) redox couple is developed to disrupt the tumor cell redox balance by concurrently catalyzing ROS generation and GSH depletion. Osmium‐treated cells exhibit multiple cell death pathways, including apoptosis, ferroptosis, and immunogenic cell death.
Wan‐Qiong Huang, Tao Huang, Yiming Hao, Gui‐Feng Huang, Yi‐Lang Yan, Xin Fang, Ying Chen, Xiao‐Long Wei, Wai‐Lun Man, Wen‐Xiu Ni   +9 more
wiley   +1 more source

Chlorates and perchlorates as potential high-energy materials: chlorate- and perchlorate-substituted methanes

Heliyon, 2019
The structures and properties of thirty-three of the thirty-four possible chlorato-Cl-, chlorato-O- and perchlorato-derivatives of methane have been computed using the range-separated hybrid generalized gradient approximation density functional method ...
Amelia G. McArthur, Robert W. Zoellner
doaj   +1 more source

Sensor technologies for the detection and monitoring of endocrine-disrupting chemicals

Frontiers in Bioengineering and Biotechnology, 2023
Endocrine-disrupting chemicals (EDCs) are a class of man-made substances with potential to disrupt the standard function of the endocrine system. These EDCs include phthalates, perchlorates, phenols, some heavy metals, furans, dimethoate, aromatic ...
Muhammad Musaddiq Shah, Khurshid Ahmad, Sonia Boota, Tor Jensen, Michael R. La Frano, Joseph Irudayaraj, Joseph Irudayaraj, Joseph Irudayaraj   +7 more
doaj   +1 more source

2-Chloroanilinium perchlorate [PDF]

Acta Crystallographica Section E Structure Reports Online, 2012
In the crystal of the title compound, C(6)H(7)ClN(+)·ClO(4) (-), a layer-like structure parallel to the bc plane is formed through N-H⋯O hydrogen bonds between the cations and anions. These layers are connected by weak C-H⋯O inter-actions, forming a three-dimensional network.
Benhua Zhou, Jin Cai
openaire   +3 more sources

A Strong Lewis Acidic Diethylsilylium Catalyst for Direct Sulfonamidation of Challenging Ketones

Advanced Science, EarlyView.
Low‐substitution‐order silylium ions (R2HSi+) exhibit exceptional Lewis acidic activity. We report diethylsilylium‐catalyzed reductive sulfonamidation of functionalized ketones to access β‐amino esters. The in situ generated ion pair shows enhanced reactivity, with diethylsilane serving as both reductant and precatalyst. The developed protocol proceeds
Woo Hee Kim, Muhammad Israr, You Kyoung Chung, Shinwon Ham, Joonsuk Huh, Han Yong Bae   +5 more
wiley   +1 more source

Copper(II/III) Redox Couple Enables C─H Methylation via a Radical Mechanism Analogous to SAM Enzymes

Angewandte Chemie, EarlyView.
Biological C–H methylation proceeds through radical pathways mediated by one‐electron redox cofactors, yet no synthetic model has reproduced this reactivity. Here, we report the first isolable Cu(II/III)–methyl complexes that mediate C–H methylation through hydrogen atom transfer and methyl radical rebound.
Emily N. Doss, Curtis E. Moore, Shiyu Zhang   +2 more
wiley   +2 more sources

Deep‐Ultraviolet (DUV) Raman and Fluorescence of Perchlorates and Chlorates: Implications for the Detection of Oxychlorines by the SHERLOC Instrument in Jezero Crater, Mars

Earth and Space Science
Oxychlorines (i.e., perchlorates (ClO4−) and chlorates (ClO3−)) have been detected by several landed missions on Mars at various locations. These missions have provided crucial information about the geographic distribution and abundances of oxychlorines ...
J. V. Clark, R. S. Jakubek, P. Conrad, E. Cardarelli, D. Buckner, A. Corpolongo, W. J. Abbey, K. Hand, M. Fries, P. Casbeer, S. Siljeström, F. M. McCubbin, S. Sharma, C. Lee, R. Bhartia, A. Steele   +15 more
doaj   +1 more source