Results 281 to 290 of about 691,914 (362)

Pharmacokinetics, Safety, and Skin Irritation and Sensitization Potential of Clascoterone Cream in Early‐Phase Clinical Study Participants

Clinical Pharmacology in Drug Development, EarlyView.
Abstract Clascoterone is an androgen receptor inhibitor approved for the treatment of acne vulgaris in patients 12 years of age and older. Here, we report results of 5 phase 1 studies that assessed the pharmacokinetics (PK), safety, and skin irritation and sensitization potential of clascoterone cream 1% in healthy participants and patients with acne ...
Andrea Francesco Daniele Di Stefano, Milko Massimiliano Radicioni, Gerhard Garhöfer, Martina Cartwright, Markus Müller, Iris Kopeloff, Luigi Moro, Nicholas Squittieri, Alessandro Mazzetti   +8 more
wiley   +1 more source

Metagenomic next-generation sequencing (mNGS) versus tissue culture technique (TCT) in diagnosis of spinal infection: a systematic review and meta-analysis. [PDF]

Sci Rep
Li YC, Liu YX, Li L, Wang H, Zhao ZR, Yao ZY.   +5 more
europepmc   +1 more source

Evaluation of CYP2C19 Clinical Decision Support Alerts to Guide P2Y12 Inhibitor Prescribing

Clinical Pharmacology &Therapeutics, EarlyView.
P2Y12 inhibitor selection involves numerous factors, including CYP2C19 genetics, since evidence demonstrates reduced clopidogrel efficacy in patients with decreased or no function CYP2C19 variants. In 2020, Indiana University health embedded interruptive clinical decision support (CDS) alerts in the electronic health record (EHR) to recommend ...
Ashley N. Springer, Leah A. Alicea, Yemi Gafari, Tayler B. Smith, Sheryl Lynch, Amy M. Breman, Jennelle C. Hodge, Victoria M. Pratt, Nicholas R. Powell, Rolf P. Kreutz, Daniel P. Kobold, Michael T. Eadon, Emma M. Tillman, Tyler Shugg, Todd C. Skaar   +14 more
wiley   +1 more source

Solute-Vehicle-Skin Interactions and Their Contribution to Pharmacokinetics of Skin Delivery. [PDF]

Pharmaceutics
Tapfumaneyi P, Phan K, Huang Y, Sodsri K, Namjoshi S, Maibach H, Mohammed Y.   +6 more
europepmc   +1 more source

Experimental model for percutaneous tracheostomy training. [PDF]

Braz J Otorhinolaryngol
Namur CS, Saleh KS, Nakai MY, Suehara AB, Gonçalves AJ.   +4 more
europepmc   +1 more source

The Safety of Ultrasound-Guided Needle Approaches for Patellar Tendinopathy: A Theoretical Cadaveric Model. [PDF]

J Funct Morphol Kinesiol
Calderón-Díez L, Belón-Pérez P, Fernández-de-Las-Peñas C, Sánchez-Sánchez JL.   +3 more
europepmc   +1 more source

Efficacy and safety in synchronous core-needle biopsy and cryoablation for highly suspicious malignant pulmonary nodule. [PDF]

Cancer Imaging
Zhang T, Xu Q, Hu Y, Li H, Du H, Huang Z, Xie S, Yang M, Xu Y, Sun H.   +9 more
europepmc   +1 more source

Nephroscope-Assisted Debridement of Pancreatic Necrosis Using the Palanivelu Hydatid Trocar Cannula System: A Novel Technique. [PDF]

Cureus
Satwick BK, Mathur SK, Patankar R.
europepmc   +1 more source

Is Percutaneous Mechanical Atherothrombectomy a Durable, Cost-Effective Solution for the Treatment of Femoropopliteal In-Stent Reocclusion? [PDF]

J Soc Cardiovasc Angiogr Interv
Zeller T.
europepmc   +1 more source

Asymptomatic bilious ascites after percutaneous transhepatic cholangiogram. A case report.

, 1973
Jeffrey A. Stein, John B. Price
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