Bevel-Tip Needle Deflection Modeling, Simulation, and Validation in Multi-Layer Tissues [PDF]
Percutaneous needle insertions are commonly performed for diagnostic and therapeutic purposes as an effective alternative to more invasive surgical procedures. However, the outcome of needle-based approaches relies heavily on the accuracy of needle placement, which remains a challenge even with robot assistance and medical imaging guidance due to ...
arxiv
CO2 laser ablation, a fast, inexpensive, and reproducible method, is used to create flexible elastomer molds with millimeter‐long cavities for the fabrication of dissolvable polymer needles. Made from PVP, these milli‐needles achieve ≈560 µm penetration into porcine skin, demonstrating their potential for effective transdermal drug delivery.
Matteo Tollemeto+7 more
wiley +1 more source
Computer-aided hepatic tumour ablation [PDF]
Surgical resection of hepatic tumours is not always possible. Alternative techniques consist in locally using chemical or physical agents to destroy the tumour and this may be performed percutaneously. It requires a precise localisation of the tumour placement during ablation.
arxiv
Controlling the Error on Target Motion through Real-time Mesh Adaptation: Applications to Deep Brain Stimulation [PDF]
We present an error-controlled mesh refinement procedure for needle insertion simulation and apply it to the simulation of electrode implantation for deep brain stimulation, including brain shift. Our approach enables to control the error in the computation of the displacement and stress fields around the needle tip and needle shaft by suitably ...
arxiv +1 more source
In vivo Terahertz Sensing of Skin Cancer Patients
This study presents the first in vivo measurements of skin cancer patients in a hospital setting using a handheld THz probe. Furthermore, a new analysis approach is developed to generate a patient‐normalized THz response function, which enables clear contrast to be seen between cancer and healthy skin of the same patient.The first in vivo study of skin
Jacob J. Young+4 more
wiley +1 more source
Development of a patient-specific finite element model of the Transcatheter Aortic Valve Implantation (TAVI) procedure [PDF]
This work reports on a study to develop a patient-specific finite element model of the Transcatheter Aortic Valve Implantation procedure, using a model of a balloon-expandable percutaneous prosthetic aortic valve as a framework for the prediction of its performance.
arxiv
3D Fusion between Fluoroscopy Angiograms and SPECT Myocardial Perfusion Images to Guide Percutaneous Coronary Intervention [PDF]
Background. Percutaneous coronary intervention(PCI) in stable coronary artery disease(CAD) is commonly triggered by abnormal myocardial perfusion imaging(MPI). However, due to the possibilities of multivessel disease and variability of coronary artery perfusion distribution, opportunity exists to better align anatomic stenosis with perfusion ...
arxiv
The CNN-based Coronary Occlusion Site Localization with Effective Preprocessing Method [PDF]
The Coronary Artery Occlusion (CAO) acutely comes to human, and it highly threats the human's life. When CAO detected, Percutaneous Coronary Intervention (PCI) should be conducted timely. Before PCI, localizing the CAO is needed firstly, because the heart is covered with various arteries.
arxiv +1 more source
Enhancing Nonenzymatic Glucose Detection Through Cobalt‐Substituted Hafnia
Proposed nonenzymatic glucose sensor utilizes ultrathin hafnia films engineered with cobalt and oxygen vacancies, grown via chemical solution deposition. Cobalt atoms with multivalent state act as sites of oxidation for glucose and oxygen vacancies enhance charger transfer, allowing precise glucose oxidation with minimal interference from other ...
Jeonghyeon Oh+10 more
wiley +1 more source
Artesunate Inhibits Neointimal Hyperplasia by Promoting IRF4 Associated Macrophage Polarization
This study shows that macrophage interferon regulatory factor 4 (IRF4) improved arterial injury‐induced neointimal hyperplasia by promoting of M2 polarization via up‐regulating krüppel‐like factor 4 (KLF4) in rodent and nonhuman primate models. Notably, artesunate is identified as a potent inducer of IRF4 in macrophages, and proposed as a promising ...
Jinlin Miao+15 more
wiley +1 more source