Results 231 to 240 of about 12,107 (247)

Contributions of Genetic Variation in Astrocytes to Cell and Molecular Mechanisms of Risk and Resilience to Late‐Onset Alzheimer's Disease

Glia, Volume 73, Issue 6, Page 1166-1187, June 2025.
Main Points Generation and characterization of iPSC‐derived astrocytes from 44 aged humans. Congruence of gene expression profiles between astrocyte cultures and brain. Association of interferon response proteins with AD pathology resilience. ABSTRACT Reactive astrocytes are associated with Alzheimer's disease (AD), and several AD genetic risk variants
Hyo Lee, Richard V. Pearse II, Alexandra M. Lish, Cheryl Pan, Zachary M. Augur, Gizem Terzioglu, Pallavi Gaur, Meichen Liao, Masashi Fujita, Earvin S. Tio, Duc M. Duong, Daniel Felsky, Nicholas T. Seyfried, Vilas Menon, David A. Bennett, Philip L. De Jager, Tracy L. Young‐Pearse   +16 more
wiley   +1 more source

The Fragile X Messenger Ribonucleoprotein 1 Regulates the Morphology and Maturation of Human and Rat Oligodendrocytes

Glia, Volume 73, Issue 6, Page 1203-1220, June 2025.
Main Points Loss of FMRP impairs human and rat oligodendrocyte (OL) morphology in vitro. FMRP‐deficient OLs show impaired maturation when engrafted in hypomyelinated mice. Rat Fmr1 knockout OLs show a delay in myelin sheath formation in vivo. ABSTRACT The Fragile X Messenger Ribonucleoprotein (FMRP) is an RNA binding protein that regulates the ...
Vidya Ramesh, Eleni Tsoukala, Ioanna Kougianou, Zrinko Kozic, Karen Burr, Biju Viswanath, David Hampton, David Story, Bharath Kumar Reddy, Rakhi Pal, Owen Dando, Peter C. Kind, Sumantra Chattarji, Bhuvaneish T. Selvaraj, Siddharthan Chandran, Lida Zoupi   +15 more
wiley   +1 more source

Beyond Conventional Approaches: The Revolutionary Role of Nanoparticles in Breast Cancer

MedComm – Biomaterials and Applications, Volume 4, Issue 2, June 2025.
This review explores integrated approach of nanotechnology to breast cancer diagnosis and treatment. We highlight imaging techniques for tumor detection and biomarker analysis in biological samples for early diagnosis. Advanced therapies, including targeted drug delivery and antibody‐drug conjugates, enable precise medication transport to cancer cells,
Mohan Liu, Yusi Wang, Yan Li, Yibing Zhang, Bailing Zhou, Lei Yang, Xi Yan, Li Yang   +7 more
wiley   +1 more source

Considerations and recommendations from the ISMRM Diffusion Study Group for preclinical diffusion MRI: Part 3—Ex vivo imaging: Data processing, comparisons with microscopy, and tractography

Magnetic Resonance in Medicine, Volume 93, Issue 6, Page 2561-2582, June 2025.
Abstract Preclinical diffusion MRI (dMRI) has proven value in methods development and validation, characterizing the biological basis of diffusion phenomena, and comparative anatomy. While dMRI enables in vivo non‐invasive characterization of tissue, ex vivo dMRI is increasingly being used to probe tissue microstructure and brain connectivity.
Kurt G. Schilling, Amy F. D. Howard, Francesco Grussu, Andrada Ianus, Brian Hansen, Rachel L. C. Barrett, Manisha Aggarwal, Stijn Michielse, Fatima Nasrallah, Warda Syeda, Nian Wang, Jelle Veraart, Alard Roebroeck, Andrew F. Bagdasarian, Cornelius Eichner, Farshid Sepehrband, Jan Zimmermann, Lucas Soustelle, Christien Bowman, Benjamin C. Tendler, Andreea Hertanu, Ben Jeurissen, Marleen Verhoye, Lucio Frydman, Yohan van de Looij, David Hike, Jeff F. Dunn, Karla Miller, Bennett A. Landman, Noam Shemesh, Adam Anderson, Emilie McKinnon, Shawna Farquharson, Flavio Dell'Acqua, Carlo Pierpaoli, Ivana Drobnjak, Alexander Leemans, Kevin D. Harkins, Maxime Descoteaux, Duan Xu, Hao Huang, Mathieu D. Santin, Samuel C. Grant, Andre Obenaus, Gene S. Kim, Dan Wu, Denis Le Bihan, Stephen J. Blackband, Luisa Ciobanu, Els Fieremans, Ruiliang Bai, Trygve B. Leergaard, Jiangyang Zhang, Tim B. Dyrby, G. Allan Johnson, Julien Cohen‐Adad, Matthew D. Budde, Ileana O. Jelescu   +57 more
wiley   +1 more source

Successful Pancreas Preservation by a Perfluorocarbon-Based One-Layer Method For Subsequent Pig Islet Isolation

, 2005
Daniel Brandhorst, Marcus Iken, Mathias D. Brendel, Reinhard G. Bretzel, Heide Brandhorst   +4 more
openalex   +1 more source

Considerations and recommendations from the ISMRM diffusion study group for preclinical diffusion MRI: Part 2—Ex vivo imaging: Added value and acquisition

Magnetic Resonance in Medicine, Volume 93, Issue 6, Page 2535-2560, June 2025.
Abstract The value of preclinical diffusion MRI (dMRI) is substantial. While dMRI enables in vivo non‐invasive characterization of tissue, ex vivo dMRI is increasingly being used to probe tissue microstructure and brain connectivity. Ex vivo dMRI has several experimental advantages including higher SNR and spatial resolution compared to in vivo studies,
Kurt G. Schilling, Francesco Grussu, Andrada Ianus, Brian Hansen, Amy F. D. Howard, Rachel L. C. Barrett, Manisha Aggarwal, Stijn Michielse, Fatima Nasrallah, Warda Syeda, Nian Wang, Jelle Veraart, Alard Roebroeck, Andrew F. Bagdasarian, Cornelius Eichner, Farshid Sepehrband, Jan Zimmermann, Lucas Soustelle, Christien Bowman, Benjamin C. Tendler, Andreea Hertanu, Ben Jeurissen, Marleen Verhoye, Lucio Frydman, Yohan van de Looij, David Hike, Jeff F. Dunn, Karla Miller, Bennett A. Landman, Noam Shemesh, Adam Anderson, Emilie McKinnon, Shawna Farquharson, Flavio Dell'Acqua, Carlo Pierpaoli, Ivana Drobnjak, Alexander Leemans, Kevin D. Harkins, Maxime Descoteaux, Duan Xu, Hao Huang, Mathieu D. Santin, Samuel C. Grant, Andre Obenaus, Gene S. Kim, Dan Wu, Denis Le Bihan, Stephen J. Blackband, Luisa Ciobanu, Els Fieremans, Ruiliang Bai, Trygve B. Leergaard, Jiangyang Zhang, Tim B. Dyrby, G. Allan Johnson, Julien Cohen‐Adad, Matthew D. Budde, Ileana O. Jelescu   +57 more
wiley   +1 more source

Clinical neuropathology of early‐stage Pick's disease initially diagnosed as depressive disorder: A case report and case series comparison

Psychiatry and Clinical Neurosciences Reports, Volume 4, Issue 2, June 2025.
This case of a 56‐year‐old patient who presented with apathy and few typical behavioral symptoms was initially diagnosed with depressive disorder. Postmortem examination revealed numerous Pick bodies (which were immunopositive for phosphorylated tau and 3‐repeat tau but negative for 4‐repeat tau), focal atrophy in the frontal lobes, and resulted in a ...
Araki Kimura, Ito Kawakami, Kenji Ikeda, Akito Nagakura, Kazuhiro Niizato, Kenichi Oshima, Tadafumi Kato, Masato Hasegawa   +7 more
wiley   +1 more source

Relation Between Brain Morphological Features and Psychiatric Hospitalization Risk in Major Depressive and Bipolar Disorders

Acta Psychiatrica Scandinavica, Volume 151, Issue 6, Page 689-697, June 2025.
ABSTRACT Introduction Patients with mood disorders, especially, major depressive disorder (MDD) and bipolar disorder (BD), are at heightened risk of relapse and psychiatric rehospitalizations. Therefore, there is an urgent need to identify modifiable biomarkers to inform personalized and intensified prevention strategies for those at the greatest risk ...
Kamilla W. Miskowiak, Julian Macoveanu, Brice Ozenne, Emily E. Beaman, Vibeke H. Dam, Patrick M. Fisher, Gitte M. Knudsen, Lars V. Kessing, Martin B. Jørgensen, Vibe G. Frokjaer, Anjali Sankar   +10 more
wiley   +1 more source

Neural correlates of children with avoidant restrictive food intake disorder symptoms: large‐scale neuroanatomical analysis of a paediatric population

Journal of Child Psychology and Psychiatry, Volume 66, Issue 6, Page 785-795, June 2025.
Background Avoidant restrictive food intake disorder (ARFID) is a recently recognised feeding and eating disorder and is characterised by a lack of interest and motivation to eat. Despite burgeoning research, few studies to date have explored the underlying neurobiology of ARFID.
Michelle Sader, Holly A. Harris, Gordon D. Waiter, Pauline W. Jansen, Justin H.G. Williams, Tonya White   +5 more
wiley   +1 more source

Reduced prefrontal activation during cognitive control under emotional interference in chronic insomnia disorder

Journal of Sleep Research, Volume 34, Issue 3, June 2025.
Summary This study investigated the altered neural activation underlying cognitive control under emotional and sleep‐related interference conditions and its role in subjective sleep disturbance in patients with chronic insomnia disorder. In total, 48 patients with chronic insomnia disorder, and 48 age‐, sex‐ and body mass index‐matched controls were ...
Sun‐Young Kim, Kyung Hwa Lee, Jeong Eun Jeon, Ha Young Lee, Jin Hyeok You, Jiyoon Shin, Min Cheol Seo, Won Woo Seo, Yu Jin Lee   +8 more
wiley   +1 more source