Results 161 to 170 of about 277,332 (311)

An ATP7A‐Mediated Endogenous Regulation Bio‐Clay Enzyme Enables Self‐Amplified Copper Accumulation for Immunogenic Pyrop

open access: yesAdvanced Science, EarlyView.
A self‐amplifying bio‐clay nanozyme (Bio‐Clayzyme) disrupts tumor metabolic homeostasis through endogenous copper transporter ATPase (ATP7A) downregulation, enhancing cascade catalysis and triggering immunogenic pyroptosis for effective tumor immunotherapy.
Weimin Xie   +4 more
wiley   +1 more source

Spontaneous esophageal perforation: case report. [PDF]

open access: yes, 2007
The treatment of esophageal perforation is difficult and controversial because of small amount of cases. Usually patients condition is bad and proper diagnosis is delayed.
Gruslys, Vygantas,   +3 more
core  

Q‐LEAP: Millisecond Hyperdimensional Optimization for Full‐Spectrum Optical Metamaterials

open access: yesAdvanced Science, EarlyView.
Q‐LEAP integrates physics‐informed residual machine learning with factorization‐machine‐encoded quantum annealing to design full‐spectrum optical metamaterials. It explores a 2108 design space and, in a single 2.56 ms annealing step, reaches 85.83% of the theoretical FoM limit, enabling selective 5‐8 µm emission with 3–5 and 8–14 µm suppression and ∼40×
Zikang Guo   +3 more
wiley   +1 more source

HECTD1 Directs HIF‐1α to Facilitate Intestinal Inflammation and Carcinogenesis via Promoting Th17 Differentiation and Glycolysis

open access: yesAdvanced Science, EarlyView.
HECTD1 emerges as an upstream amplifier of Th17 metabolic programming by promoting K63‐linked ubiquitination of IGF2BP3 and enhancing HIF‐1α translation. HIF‐1α reciprocally drives HECTD1 transcription, establishing a positive regulatory loop that sustains glycolysis and Th17 differentiation.
Shuiyu Xu   +12 more
wiley   +1 more source

Mechanical Distraction Engages a Neuro‐Immune Program to Drive Regenerative Soft‐Tissue Healing in Ilizarov Bone Transport

open access: yesAdvanced Science, EarlyView.
Ilizarov bone transport accelerates healing of soft‐tissue wounds through unclear mechanisms. In a rat model, sustained mechanical distraction elicits calcitonin gene‐related peptide (CGRP)‐dominant sensory reinnervation, creating a niche that shifts immune cells from inflammatory to repair‐promoting states and speeds re‐epithelialization.
Yueliang Zhu   +9 more
wiley   +1 more source

Surface‐Selective Pt Enrichment for Stabilizing Ultrathin 2D PtCu Nanosheets Toward Durable Oxygen Reduction

open access: yesAdvanced Science, EarlyView.
Ultrathin 2D alloy nanosheet catalysts could offer exceptional catalytic activity but suffer from severe structural instability. Here, a surface‐selective Pt enrichment strategy via galvanic replacement effectively stabilizes PtCu Nanosheets while preserving their ∼ 1 nm thickness and (111) facets.
HyunWoo J. Yang   +7 more
wiley   +1 more source

Multi‐modal Operando Analysis of Lithium–Sulfur Batteries: A Comparative Study on the Influence of Electrolyte Composition

open access: yesAdvanced Energy Materials, EarlyView.
The influence of different electrolytes on Lithium–sulfur batteries is investigated. Multimodal operando analysis, including Raman, UV–vis, and Impedance spectroscopy is used to study degradation mechanisms. The solubility of polysulfides in the electrolyte is crucial for battery capacity and lifetime.
Oliver Löhmann   +3 more
wiley   +1 more source

One‐Year Healthcare Utilization and Costs After Emergency Department Encounters for Uncomplicated Appendicitis: A Statewide Observational Study

open access: yesAnnals of Gastroenterological Surgery, EarlyView.
ABSTRACT Objective Non‐operative management with antibiotics has emerged as an alternative to appendectomy for uncomplicated appendicitis. This study compared one‐year healthcare costs and utilization outcomes after operative versus non‐operative management of uncomplicated appendicitis using statewide administrative data.
Andrew C. Meltzer   +5 more
wiley   +1 more source

Gastric perforation presenting as bilateral scrotal pneumatoceles

open access: yes, 1999
Although processus vaginalis is patent in the majority of newborn infants, the expression of an intraabdominal pathology such as gastrointestinal perforation or bleeding in the scrotum is very rare.
SARIHAN, HALUK   +5 more
core   +1 more source

Laparoscopic Versus Open Surgery for Diverticular Disease: A Structured Review Across Clinical Settings and Operative Strategies

open access: yesAnnals of Gastroenterological Surgery, EarlyView.
ABSTRACT Laparoscopic surgery is increasingly used to treat colonic diverticulitis; however, its role in emergency, perforated, high‐risk, and procedure‐specific settings remains uncertain. This structured narrative review evaluated and synthesized comparative evidence by clinical setting, operative strategy, and patient risk profile to provide a ...
Marie Hanaoka   +4 more
wiley   +1 more source

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