Results 171 to 180 of about 5,668 (300)

Engineering technology resilience through informatics safety science. [PDF]

J Am Med Inform Assoc, 2017
Coiera E, Magrabi F, Talmon J.
europepmc   +1 more source

pH‐mediated activation of the lysosomal arginine sensor SLC38A9

FEBS Letters, EarlyView.
Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley   +1 more source

Development of a new method for maintainability and downtime analysis of mining machinery. [PDF]

Sci Rep
Dashtaki MR, Jafari AJ, Hoseinie SH.
europepmc   +1 more source

Selection of Internal Standards for Quantitative Matrix-Assisted Laser Desorption/Ionization Mass Spectrometric Analysis Based on Correlation Coefficients. [PDF]

ACS Omega, 2019
Yang S, Mu L, Feng R, Kong X.
europepmc   +1 more source

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

Lesion characteristics of long application time ablation using unipolar half-normal saline irrigation and bipolar normal saline irrigation. [PDF]

Indian Pacing Electrophysiol J
Kasai T, Saitoh O, Oikawa A, Suzuki N, Ikami Y, Hasegawa Y, Otsuki S, Inomata T, Furushima H, Chinushi M.   +9 more
europepmc   +1 more source

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

A novel global health index framework for asset prognostics and health management in the oil and gas industry. [PDF]

Sci Rep
Alfahdi K, Gultekin H, Summad E.
europepmc   +1 more source

"Because Work Time Is Life Time" - Employees' Perceptions of Individual Overemployment, Its Causes and Its Consequences. [PDF]

Front Psychol, 2019
Hiemer J, Andresen M.
europepmc   +1 more source

Theatre Reviews [PDF]

, 2012

core   +1 more source