Results 111 to 120 of about 18,907,798 (310)
Pay One, Get Hundreds for Free: Reducing Cloud Costs through Shared Query Execution
, 2018 Cloud-based data analysis is nowadays common practice because of the lower system management overhead as well as the pay-as-you-go pricing model. The pricing model, however, is not always suitable for query processing as heavy use results in high costs ...
Chen Chung-Min +6 more
core +1 more source
Calpain small subunit homodimerization is robust and calcium‐independent
FEBS Letters, EarlyView.Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy +4 more
wiley +1 more source
FES rehabilitation platform with real-time control and performance feedback. [PDF]
, 2017 Osteoporosis after spinal cord injury is associated with low-trauma fractures, and consequently with increased risk of morbidity and mortality. The loss of bone mass density (BMD) due to paraplegia can be reduced through cyclical electrically-induced ...
Andrews, B. +5 more
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Public Performance Metrics: Driving Physician Motivation and Performance [PDF]
, 2020 Introduction: As providers transition from “fee-for-service” to “pay-for-performance” models, focus has shifted to improving performance. This trend extends to the emergency department (ED) where visits continue to increase across the United States.
Barton, Erik D. +6 more
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Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
, 2022 Purpose This paper seeks to explore the question of how to investigate the contribution of the operational network (comprising sales service, logistics, planning, production, etc.) to operational performance. In doing so, the paper aims to link concepts from organisational and social psychology to production planning and control.
Wijngaard, Jacob +2 more
openaire +1 more source
Towards Designing a Performance Measurement System for the CGIAR : Draft Report [PDF]
, 2003 The System Office established the Working Group on Performance Measurement in May 2003, under the Co-Chairmanship of two ExCo members: Kevin Cleaver (ExCo/FC Chair) and Luis Arango (ExCo/PC member).
CGIAR Working Group on Performance Measurement
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FEBS Letters, EarlyView.Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura +2 more
wiley +1 more source
The depression report: a new deal for depression and anxiety disorders. [PDF]
Crippling depression and chronic anxiety are the biggest causes of misery in Britain today. They are the great submerged problem, which shame keeps out of sight. But if you mention them, you soon discover how many families are affected.
London School of Economics and Political Science. Centre for Economic Performance, Mental Health Policy Group
core +1 more source